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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. Dociparstat sodium

    BRIGHT MINDS BIOSCIENCES INC.

    Acute Myeloid Leukemia

    phase 1 small molecule completed

    1 trial

  2. Dofetilide

    BRIGHT MINDS BIOSCIENCES INC.

    Drug-induced QT Prolongation

    phase 1 small molecule completed

    1 trial

  3. Domvanalimab

    Arcus Biosciences

    Solid Tumor, Unspecified, Adult

    phase 1 small molecule completed

    1 trial

  4. Donepezil

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  5. Donepezil Dihydroxynaphthalate for Injection

    Shanghai University of Traditional Chinese Medicine

    Alzheimer Disease

    phase 1 small molecule active

    1 trial

  6. Donepezil Hydrochloride

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  7. Dordaviprone (ONC201)

    Jazz Pharmaceuticals Ireland Limited

    Diffuse Intrinsic Pontine Glioma

    phase 1 small molecule terminated

    1 trial

  8. Dose Escalation Study with Bispecific Antibodies in Adult Patients with Lupus Nephritis

    Lacuna Pharma Pty Ltd

    Lupus Nephritis

    phase 1 other active

    1 trial

  9. Dose dense re-challenge of high dose methotrexate (hd-mtx) with glucarpidase (cpg2) for relapsed primary cns lymphoma (pcnsl): A phase 1 trial (METHOGLU)

    Pari Pharma GmbH

    Oncology: RELAPSED PRIMARY CNS LYMPHOMA

    phase 1 other active

    1 trial

  10. Dose escalation

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Poor Graft Function

    phase 1 mab active

    1 trial

  11. Dose escalation of SA030

    Suzhou Ribo Life Science Co.

    Obese

    phase 1 small molecule active

    1 trial

  12. Dose escalation trial of BNT152+153 in patients with cancer

    BioNTech SE

    Various solid tumors that are metastatic or unresectable

    phase 1 other active

    1 trial

  13. Dose of 60 mg/kg Fraction IV-1 Alpha1-Proteinase Inhibitor

    Takeda

    Alpha 1-Antitrypsin Deficiency

    phase 1 mab completed

    1 trial

  14. Double-Blind, Randomized, Placebo-Controlled, Phase 1b, Pharmacodynamic Trial of TEV-56192 Following a Single Intravenous Administration in Healthy Participants

    Lacuna Pharma Pty Ltd

    Pruritus

    phase 1 other active

    1 trial

  15. Doxorubicin

    United Therapeutics Europe Ltd

    Pancreatic Ductal Adenocarcinoma

    phase 1 small molecule terminated

    1 trial

  16. Doxycycline Monohydrate

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  17. Dronabinol

    BRIGHT MINDS BIOSCIENCES INC.

    Bipolar Disorder

    phase 1 small molecule terminated

    1 trial

  18. Dronabinol

    BRIGHT MINDS BIOSCIENCES INC.

    Schizophrenia

    phase 1 small molecule completed

    1 trial

  19. Dronabinol Capsules

    BRIGHT MINDS BIOSCIENCES INC.

    HIV

    phase 1 small molecule active

    1 trial

  20. Drospirenone/Ethinyl Estradiol (Gianvi®)

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  21. Drug 601

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Wet Age-related Macular Degeneration

    phase 1 small molecule active

    1 trial

  22. Drug 601

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Diabetic Macular Edema

    phase 1 small molecule active

    1 trial

  23. Drug A (Blinded Drug)

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Use Disorder

    phase 1 small molecule on hold

    1 trial

  24. Drug Product De-TIL-0255

    Nurix Therapeutics

    Platinum-resistant Ovarian Cancer

    phase 1 mab terminated

    1 trial

  25. Drug-AZD8931

    AstraZeneca

    Breast Neoplasm

    phase 1 small molecule terminated

    1 trial

  26. Drug-Drug Interaction Study With BIA 28-6156 and Clarithromycin, Midazolam, and Dabigatran Etexilate in Healthy Participants

    BIAL - Portela & Ca

    Healthy volunteers

    phase 1 other active

    1 trial

  27. Drug: AT-527 + rosuvastatin

    Atea Pharmaceuticals

    Healthy Volunteer Study

    phase 1 small molecule completed

    1 trial

  28. Drug: BG-T187

    BEONE MEDICINES AUS PTY LTD

    Advanced Solid Tumor

    phase 1 small molecule active

    1 trial

  29. Drugs administration

    Hospital Authority, Hong Kong

    Rotator Cuff Tears of the Shoulder

    phase 1 small molecule active

    1 trial

  30. Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy

    Nanjing Legend Biotech Co.

    Refractory B Acute Lymphoblastic Leukemia

    phase 1 small molecule terminated

    1 trial

  31. Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy

    Nanjing Legend Biotech Co.

    Lymphoma, B-Cell

    phase 1 small molecule terminated

    1 trial

  32. Dual-Wavelength Quantitative Fluorescence Endoscopy for Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer: A Phase I Multicenter Feasibility and Safety Study

    Disc Medicine

    Esophageal cancer

    phase 1 other active

    1 trial

  33. Dupilumab

    Regeneron UK Limited

    Atopic Disorders

    phase 1 small molecule completed

    1 trial

  34. Dupilumab (SAR231893)

    Regeneron UK Limited

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  35. Dupilumab (SAR231893)

    Regeneron UK Limited

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  36. E0302 SR1

    Eisai Co.,

    Healthy Subjects

    phase 1 small molecule completed

    1 trial

  37. E6007

    Eisai Co.,

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  38. E7080

    Eisai Co.,

    Cancer: Solid Tumors

    phase 1 small molecule completed

    1 trial

  39. E7766

    Eisai Co.,

    Lymphoma

    phase 1 small molecule terminated

    1 trial

  40. EBC-129

    BRIGHT MINDS BIOSCIENCES INC.

    Advanced Solid Tumours

    phase 1 small molecule active

    1 trial

  41. EBV immunological agent

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Malignant Tumor

    phase 1 mab active

    1 trial

  42. ECHO (Empowering Our Community & Health Outcomes)

    BRIGHT MINDS BIOSCIENCES INC.

    Smoking Cessation

    phase 1 other terminated

    1 trial

  43. ECIG liquid vehicles

    BRIGHT MINDS BIOSCIENCES INC.

    Nicotine Exposure

    phase 1 other completed

    1 trial

  44. EDG-15400

    Edgewise Therapeutics

    Healthy Adults

    phase 1 small molecule active

    1 trial

  45. EDG-5506

    Edgewise Therapeutics

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  46. EDG-5506

    Edgewise Therapeutics

    Muscular Dystrophies

    phase 1 small molecule completed

    1 trial

  47. EDG-5506 Tablet

    Edgewise Therapeutics

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  48. EDG-7500

    Edgewise Therapeutics

    Healthy Adult Participants

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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