Intelligence · Clinical Pipeline

Phase III Pipeline Programs

Late-stage pivotal and registrational clinical programs nearing regulatory submission.

Programs: 5,427

Quick answer

NovaPharmaNews tracks 5,427 phase iii pharmaceutical pipeline programs from ClinicalTrials.gov. Late-stage pivotal and registrational clinical programs nearing regulatory submission.

Top sponsors

"myk-461 capsules, placebo is a solid oral dosage form in size 2 gelatin capsules each containing 120 mg of an excipient blend. it is intended as a placebo to match myk-461 capsules of all active strengths", Mavacamten, Mavacamten, Mavacamten, Mavacamten, Mavacamten

Bristol-Myers Squibb Australia Pty Ltd

Symptomatic Obstructive Hypertrophic Cardiomyopathy

phase 3 small molecule active

1 trial
,4-diaminopyridine

Ultragenyx UK Limited

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

phase 3 small molecule completed

1 trial
-

Disc Medicine

Resectable colorectal rectal metastases without extrahepatic disease

phase 3 small molecule active

1 trial
-, -, ERYTHROPOIETIN , DANAZOL , VAY736, -, ENTECAVIR , Placebo to VAY736 150 mg/1 mL concentrate for solution for infusion, -, -

Novartis Pharmaceuticals

warm autoimmune haemolytic anaemia (wAIHA)

phase 3 small molecule active

1 trial
-, -, IMETELSTAT, -, -, -, -, -, -, -

Geron Netherlands B.V.

Myelofibrosis

phase 3 small molecule active

1 trial
-, -, PACLITAXEL , DOXORUBICIN HYDROCHLORIDE, LIPOSOMAL, KEYTRUDA 25 mg/mL concentrate for solution for infusion, MK-2870, MK-2870, DOXORUBICIN , CAPECITABINE , PACLITAXEL ALBUMIN-BOUND, DEXAMETHASONE , PARACETAMOL

Merck Sharp and Dohme

Hormone receptor positive breast cancer

phase 3 small molecule active

1 trial
-, Apalutamide placebo, JNJ-56021927

Janssen-Cilag International N.V.

Metastatic Hormone-sensitive Prostate Cancer

phase 3 small molecule active

1 trial
-, COLESTYRAMINE , AUBAGIO 14 mg film-coated tablets, -, Matched Placebo to Test, Tolebrutinib, Matched Placebo for Comparator Teriflunomide

Sanofi-aventis Healthcare Pty Ltd

Nervous system diseases

phase 3 small molecule active

1 trial
-, DOCETAXEL , DEXAMETHASONE , -, -, MK-2870, PARACETAMOL, COMBINATIONS EXCL. PSYCHOLEPTICS, PEMETREXED

Merck Sharp and Dohme

Non-small Cell Lung Cancer (NSCLC)

phase 3 small molecule active

1 trial
-, DOCETAXEL , JDQ443

Novartis Pharmaceuticals

Advanced non-small cell lung cancer harboring the KRAS G12C mutation

phase 3 small molecule active

1 trial
-, IRINOTECAN , PARACETAMOL , -, -, PACLITAXEL , TRIFLURIDINE, COMBINATIONS, MK-2870, DOCETAXEL

Merck Sharp and Dohme

advanced or metastatic gastric adenocarcinoma, gastroesophageal junction adenocarcinoma, or esophageal adenocarcinoma

phase 3 small molecule active

1 trial
-, KEYTRUDA 25 mg/mL concentrate for solution for infusion, -, CAPECITABINE , PARACETAMOL , MK-2870, DEXAMETHASONE

Merck Sharp and Dohme

Triple negative breast cancer.

phase 3 small molecule active

1 trial
-, MVASI 25 mg/mL concentrate for solution for infusion, MVASI 25 mg/mL concentrate for solution for infusion, MK-2870, Avastin 25 mg/ml concentrate for solution for infusion., Avastin 25 mg/ml concentrate for solution for infusion.

Merck Sharp and Dohme

Ovarian cancer

phase 3 small molecule active

1 trial
-, PACLITAXEL , KEYTRUDA 25 mg/mL concentrate for solution for infusion., Avastin 25 mg/ml concentrate for solution for infusion., MK-2870, MVASI 25 mg/mL concentrate for solution for infusion, CARBOPLATIN , MVASI 25 mg/mL concentrate for solution for infusion, Avastin 25 mg/ml concentrate for solution for infusion., CISPLATIN

Merck Sharp and Dohme

Persistent, Recurrent, or Newly Diagnosed Metastatic Cervical Cancer With PD-L1 CPS Greater Than or Equal to 1

phase 3 small molecule active

1 trial
-, PARACETAMOL , CILAZAPRIL , Dapirolizumab pegol, EPINEPHRINE , DIPHENHYDRAMINE , -, -, -, -, -, -, -

Lacuna Pharma Pty Ltd

Systemic lupus erythematosus (SLE)

phase 3 small molecule active

1 trial
-, PARACETAMOL , MK-2870, PACLITAXEL , -, KEYTRUDA 25 mg/mL concentrate for solution for infusion, -, CARBOPLATIN , PACLITAXEL ALBUMIN-BOUND, DEXAMETHASONE

Merck Sharp and Dohme

Participants with treatment-naïve metastatic squamous Non-small Cell Lung Cancer (NSCLC)

phase 3 small molecule active

1 trial
-, Placebo to ianalumab 150 mg/1 mL concentrate for solution for infusion, -, ENTECAVIR , -, ELTROMBOPAG, -, ELTROMBOPAG, ELTROMBOPAG, VAY736, -, ELTROMBOPAG

Novartis Pharmaceuticals

Primary immune thrombocytopenia (ITP)

phase 3 small molecule active

1 trial
-, Rozanolixizumab

Lacuna Pharma Pty Ltd

Generalized Myasthenia Gravis

phase 3 small molecule active

1 trial
-, Rozanolixizumab

Lacuna Pharma Pty Ltd

Generalized Myasthenia Gravis

phase 3 small molecule active

1 trial
-, Sodium butyrate 1,1 g/L sol prep

ISTA Pharma Limited

Hirschsprung's disease

phase 3 small molecule active

1 trial
-, TACROLIMUS , Amlitelimab, PIMECROLIMUS , Placebo, Amlitelimab

Sanofi-aventis Healthcare Pty Ltd

Dermatitis atopic

phase 3 small molecule active

1 trial
-, TECHNETIUM (99MTC) COMPOUNDS, -, JNJ-56021927

Janssen-Cilag International N.V.

High risk recurrent prostate cancer previously treated with radical prostatectomy

phase 3 small molecule active

1 trial
-, VALSARTAN AND SACUBITRIL , CARVEDILOL , DAPAGLIFLOZIN , -, RAMIPRIL , -, -, LOSARTAN

Pari Pharma GmbH

Heart failure

phase 3 small molecule active

1 trial
0.05% Voclosporin Ophthalmic Solution (VOS)

Aurinia Pharmaceuticals

Dry Eye Syndrome

phase 3 small molecule completed

1 trial
0.2 mg/kg ketamine

United Therapeutics Europe Ltd

Depression

phase 3 small molecule terminated

1 trial
0.454% stannous fluoride

Colgate Oral Care

Calculus, Dental

phase 3 small molecule completed

1 trial
0.454% stannous fluoride

Colgate Oral Care

Oral Malodor

phase 3 small molecule completed

1 trial
0.9 % w/v Sodium Chloride Injection, Reblozyl 25 mg powder for solution for injection, Reblozyl 75 mg powder for solution for injection

Celgene Europe Limited

Anemia associated with myeloproliferative neoplasm (MPN)-associated myelofibrosis (MF)

phase 3 small molecule active

1 trial
0.9% (w/v) sodium chloride with 5 mM phosphate buffered solution, Zilebesiran

Alnylam Netherlands B.V.

High cardiovascular risk, Established cardiovascular disease, Hypertension

phase 3 small molecule active

1 trial
0.9% Saline, PARACETAMOL , Felzartamab, CETIRIZINE , LORATADINE , FAMOTIDINE , DIPHENHYDRAMINE , LEVOCETIRIZINE , DESLORATADINE , FEXOFENADINE , METHYLPREDNISOLONE

Biogen

IgA nephropathy

phase 3 small molecule active

1 trial
0.9% Sodium Chloride Solution, Glenzocimab

Pari Pharma GmbH

Acute ischemic stroke

phase 3 small molecule active

1 trial
0.9% Sodium Chloride for Injection, KEYTRUDA 25 mg/mL concentrate for solution for infusion, KEYTRUDA 25 mg/mL concentrate for solution for infusion., JEMPERLI 500 mg concentrate for solution for infusion

GlaxoSmithKline

Lung Cancer, Non-Small Cell

phase 3 small molecule active

1 trial
0.9% Sodium Chloride, JNJ-78901563

Xian-Janssen Pharmaceutical

Invasive Extraintestinal Pathogenic Escherichia coli Disease

phase 3 small molecule active

1 trial
0.9% Sodium chloride, Amvuttra 25 mg solution for injection in pre-filled syringe

Alnylam Netherlands B.V.

Transthyretin Amyloidosis with Cardiomyopathy (ATTR Amyloidosis with Cardiomyopathy)

phase 3 small molecule active

1 trial
0.9% sodium chloride, GB-0895

Generate Biomedicines

severe uncontrolled asthma

phase 3 small molecule active

1 trial
0.9% sodium chloride, Lepodisiran

Eli Lilly Co.

Atherosclerotic Cardiovascular Disease Elevated lp(a)

phase 3 small molecule active

1 trial
0.9% w/v sodium chloride solution for intravenous infusion, Panzyga 100 mg/ml Infusionslösung

Maze Therapeutics

Pediatric acute-onset neuropsychiatric syndrome (PANS)

phase 3 small molecule active

1 trial
1 apical pleurectomy

Hospital Authority, Hong Kong

Pneumothorax

phase 3 other active

1 trial
1% Clascoterone Cream

Sunshine Guojian Pharmaceutical (Shanghai) Co.,

Acne Vulgaris

phase 3 small molecule active

1 trial
1.0% C31G SAVVY vaginal gel

United Therapeutics Europe Ltd

HIV Infections

phase 3 small molecule active

2 trials
1.0mg/kg/day PRAX-562

Chongqing Precision Biotech Co., Ltd

Developmental and Epileptic Encephalopathy 1

phase 3 small molecule active

1 trial
10-week smoking cessation group therapy combined with NicoDerm CQ

BRIGHT MINDS BIOSCIENCES INC.

Tobacco Use Cessation

phase 3 other completed

1 trial
11C-SB207145, 11C-DASB

The George Institute

Parkinson's disease, Prodromal phase of Parkinson's disease

phase 3 small molecule active

1 trial
12-Valent Pneumococcal Conjugate Vaccine

MAIA Biotechnology

Pneumococcal Vaccines

phase 3 mab active

1 trial
131I-apamistamab

Actinium Pharmaceuticals

Acute Leukemia

phase 3 small molecule active

1 trial
177Lu-TLX250

Telix Innovations

ccRCC

phase 3 other active

1 trial
177Lu-TLX591

Telix Innovations

Metastatic Castration-resistant Prostate Cancer

phase 3 small molecule active

1 trial
18F fluciclovine

Chongqing Precision Biotech Co., Ltd

Brain Metastases

phase 3 small molecule completed

2 trials

Frequently asked questions

How many Phase III pipeline programs are in the directory?

5,427 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

Quick answer

Top sponsors

"myk-461 capsules, placebo is a solid oral dosage form in size 2 gelatin capsules each containing 120 mg of an excipient blend. it is intended as a placebo to match myk-461 capsules of all active strengths", Mavacamten, Mavacamten, Mavacamten, Mavacamten, Mavacamten

,4-diaminopyridine

-

-, -, ERYTHROPOIETIN , DANAZOL , VAY736, -, ENTECAVIR , Placebo to VAY736 150 mg/1 mL concentrate for solution for infusion, -, -

-, -, IMETELSTAT, -, -, -, -, -, -, -

-, -, PACLITAXEL , DOXORUBICIN HYDROCHLORIDE, LIPOSOMAL, KEYTRUDA 25 mg/mL concentrate for solution for infusion, MK-2870, MK-2870, DOXORUBICIN , CAPECITABINE , PACLITAXEL ALBUMIN-BOUND, DEXAMETHASONE , PARACETAMOL

-, Apalutamide placebo, JNJ-56021927

-, COLESTYRAMINE , AUBAGIO 14 mg film-coated tablets, -, Matched Placebo to Test, Tolebrutinib, Matched Placebo for Comparator Teriflunomide

-, DOCETAXEL , DEXAMETHASONE , -, -, MK-2870, PARACETAMOL, COMBINATIONS EXCL. PSYCHOLEPTICS, PEMETREXED

-, DOCETAXEL , JDQ443

-, IRINOTECAN , PARACETAMOL , -, -, PACLITAXEL , TRIFLURIDINE, COMBINATIONS, MK-2870, DOCETAXEL

-, KEYTRUDA 25 mg/mL concentrate for solution for infusion, -, CAPECITABINE , PARACETAMOL , MK-2870, DEXAMETHASONE

-, MVASI 25 mg/mL concentrate for solution for infusion, MVASI 25 mg/mL concentrate for solution for infusion, MK-2870, Avastin 25 mg/ml concentrate for solution for infusion., Avastin 25 mg/ml concentrate for solution for infusion.

-, PARACETAMOL , CILAZAPRIL , Dapirolizumab pegol, EPINEPHRINE , DIPHENHYDRAMINE , -, -, -, -, -, -, -

-, PARACETAMOL , MK-2870, PACLITAXEL , -, KEYTRUDA 25 mg/mL concentrate for solution for infusion, -, CARBOPLATIN , PACLITAXEL ALBUMIN-BOUND, DEXAMETHASONE

-, Placebo to ianalumab 150 mg/1 mL concentrate for solution for infusion, -, ENTECAVIR , -, ELTROMBOPAG, -, ELTROMBOPAG, ELTROMBOPAG, VAY736, -, ELTROMBOPAG

-, Rozanolixizumab

-, Rozanolixizumab

-, Sodium butyrate 1,1 g/L sol prep

-, TACROLIMUS , Amlitelimab, PIMECROLIMUS , Placebo, Amlitelimab

-, TECHNETIUM (99MTC) COMPOUNDS, -, JNJ-56021927

-, VALSARTAN AND SACUBITRIL , CARVEDILOL , DAPAGLIFLOZIN , -, RAMIPRIL , -, -, LOSARTAN

0.05% Voclosporin Ophthalmic Solution (VOS)

0.2 mg/kg ketamine

0.454% stannous fluoride

0.454% stannous fluoride

0.9 % w/v Sodium Chloride Injection, Reblozyl 25 mg powder for solution for injection, Reblozyl 75 mg powder for solution for injection

0.9% (w/v) sodium chloride with 5 mM phosphate buffered solution, Zilebesiran

0.9% Saline, PARACETAMOL , Felzartamab, CETIRIZINE , LORATADINE , FAMOTIDINE , DIPHENHYDRAMINE , LEVOCETIRIZINE , DESLORATADINE , FEXOFENADINE , METHYLPREDNISOLONE

0.9% Sodium Chloride Solution, Glenzocimab

0.9% Sodium Chloride for Injection, KEYTRUDA 25 mg/mL concentrate for solution for infusion, KEYTRUDA 25 mg/mL concentrate for solution for infusion., JEMPERLI 500 mg concentrate for solution for infusion

0.9% Sodium Chloride, JNJ-78901563

0.9% Sodium chloride, Amvuttra 25 mg solution for injection in pre-filled syringe

0.9% sodium chloride, GB-0895

0.9% sodium chloride, Lepodisiran

0.9% w/v sodium chloride solution for intravenous infusion, Panzyga 100 mg/ml Infusionslösung

1 apical pleurectomy

1% Clascoterone Cream

1.0% C31G SAVVY vaginal gel

1.0mg/kg/day PRAX-562

10-week smoking cessation group therapy combined with NicoDerm CQ

11C-SB207145, 11C-DASB

12-Valent Pneumococcal Conjugate Vaccine

131I-apamistamab

177Lu-TLX250

177Lu-TLX591

18F fluciclovine

Frequently asked questions

Stay Ahead in Pharma