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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. Deferitazole (disodium salt, granule)

    Takeda

    Healthy

    phase 1 small molecule terminated

    1 trial

  2. Defibrotide

    Jazz Pharmaceuticals Ireland Limited

    COVID

    phase 1 small molecule completed

    1 trial

  3. Deflazacort

    PTC THERAPEUTICS, INC.

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  4. Deflazacort

    PTC THERAPEUTICS, INC.

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  5. Deflazacort

    PTC THERAPEUTICS, INC.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  6. Deflazacort and rifampin

    PTC THERAPEUTICS, INC.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  7. Delayed Release 6 mercaptopurine

    Teva Pharma GmbH

    Crohns Disease

    phase 1 small molecule completed

    1 trial

  8. Delta-9-THC Low Dose

    BRIGHT MINDS BIOSCIENCES INC.

    Age-related Cognitive Decline

    phase 1 small molecule active

    1 trial

  9. Demcizumab

    Mereo BioPharma Group plc

    Locally Advanced or Metastatic Solid Tumors

    phase 1 small molecule completed

    1 trial

  10. Demcizumab

    Mereo BioPharma Group plc

    Primary Peritoneal Carcinoma

    phase 1 small molecule terminated

    1 trial

  11. Demcizumab

    Mereo BioPharma Group plc

    Non Small Cell Lung Cancer

    phase 1 small molecule completed

    1 trial

  12. Dendritic Cell (DC1) Vaccine

    VACCINEX, INC.

    HER2-positive Breast Cancer

    phase 1 mab active

    1 trial

  13. Dendritic Cell Vaccination

    Quantum Biopharma

    Metastatic Breast Cancer

    phase 1 mab active

    1 trial

  14. Dendritic Cell Vaccine

    United Therapeutics Europe Ltd

    Leptomeningeal Disease

    phase 1 mab active

    1 trial

  15. Dendritic cell therapy combined with surgery in mesothelioma (ENSURE)

    Disc Medicine

    Adult patients diagnosed with resectable epithelioid MPM, following first-line chemotherapy.

    phase 1 other active

    1 trial

  16. Denifanstat

    Sagimet Biosciences

    Healthy

    phase 1 small molecule completed

    1 trial

  17. DepoDur (extended-release epidural morphine)

    Pacira Ireland Limited

    Postoperative Pain

    phase 1 small molecule completed

    1 trial

  18. Descartes 30

    Cartesian Therapeutics

    Acute Respiratory Distress Syndrome

    phase 1 mab terminated

    1 trial

  19. Descartes-08

    Cartesian Therapeutics

    Multiple Myeloma

    phase 1 mab terminated

    1 trial

  20. Descartes-15

    Cartesian Therapeutics

    Refractory Multiple Myeloma

    phase 1 small molecule terminated

    1 trial

  21. Descartes-25

    Cartesian Therapeutics

    Multiple Myeloma

    phase 1 small molecule terminated

    1 trial

  22. Desmopressin Acetate 0.2 mg Tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  23. Desogestrel/ethinyl estradiol and ethinyl estradiol

    Teva Pharma GmbH

    Follicle Development

    phase 1 small molecule completed

    1 trial

  24. Detection of tumor tiSsue in pEritoneal metastases of coLorectal origin using a VEGF-targeted optical fluoresCent imaging tracer during diagnosTic laparoscopy

    Disc Medicine

    peritoneal metastases of colorectal origin

    phase 1 other active

    1 trial

  25. Dexamethasone

    NEUROCRINE BIOSCIENCES INC

    Healthy

    phase 1 small molecule completed

    1 trial

  26. Dexlansoprazole

    Takeda

    Pediatric Gastroesophageal Reflux Disease

    phase 1 small molecule terminated

    1 trial

  27. Dexlansoprazole

    Takeda

    Homeostasis

    phase 1 small molecule completed

    1 trial

  28. Dexlansoprazole

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  29. Dexlansoprazole Delayed Release Orally Disintegrating Tablets

    Takeda

    Bioavailability

    phase 1 small molecule completed

    1 trial

  30. Dexlansoprazole Injection

    The First People's Hospital of Lianyungang

    Effect of Drugs

    phase 1 small molecule active

    1 trial

  31. Dexlansoprazole MR

    Takeda

    Gastroesophageal Reflux

    phase 1 small molecule completed

    1 trial

  32. Dexmedetomidine

    The First People's Hospital of Lianyungang

    Cesarean Section, Affecting Fetus or Newborn

    phase 1 small molecule completed

    1 trial

  33. Dexmedetomidine

    The First People's Hospital of Lianyungang

    Heart Injuries

    phase 1 small molecule active

    1 trial

  34. Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg

    BioXcel Therapeutics

    Alcohol Use Disorder (AUD)

    phase 1 small molecule active

    1 trial

  35. Dexmethylphenidate Hydrochloride

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  36. Dextromethorphan HBr

    Galera Therapeutics

    Healthy

    phase 1 small molecule completed

    1 trial

  37. Digoxin

    Takeda

    Cytomegalovirus (CMV)

    phase 1 small molecule completed

    1 trial

  38. Digoxin

    The First People's Hospital of Lianyungang

    Healthy

    phase 1 small molecule completed

    1 trial

  39. Digoxin

    PUMA BIOTECHNOLOGY, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  40. Digoxin

    Hospital Authority, Hong Kong

    Healthy

    phase 1 small molecule completed

    1 trial

  41. Digoxin vs Digoxin + BEM/RZR vs Digoxin + 2h BEM/RZR

    Atea Pharmaceuticals

    Healthy Volunteer Study

    phase 1 small molecule completed

    1 trial

  42. Dihydrexidine

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine-Related Disorders

    phase 1 small molecule active

    1 trial

  43. Dinutuximab

    United Therapeutics Europe Ltd

    Neuroblastoma

    phase 1 small molecule active

    2 trials

  44. Disulfiram

    BRIGHT MINDS BIOSCIENCES INC.

    HIV Infections

    phase 1 small molecule completed

    1 trial

  45. Divalproex Sodium

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    4 trials

  46. Divalproex Sodium Extended-release 250mg

    BRIGHT MINDS BIOSCIENCES INC.

    Epilepsy

    phase 1 small molecule active

    1 trial

  47. Docetaxel

    United Therapeutics Europe Ltd

    Prostate Cancer

    phase 1 small molecule completed

    1 trial

  48. Docetaxel

    Mereo BioPharma Group plc

    Solid Tumors

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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