Intelligence Β· Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. ziftomenib

    Kura Oncology

    Gastrointestinal Stromal Tumor (GIST)

    phase 1 small molecule active

    1 trial
  2. zimberelimab

    Arcus Biosciences

    Advanced Solid Tumors

    phase 1 small molecule completed

    1 trial
  3. ziv-aflibercept

    Regeneron UK Limited

    Lymphoma

    phase 1 mab completed

    2 trials
  4. ziv-aflibercept

    Regeneron UK Limited

    Cancer

    phase 1 mab completed

    2 trials
  5. Ξ±-lactalbumin vaccine

    Anixa Biosciences Inc

    Pathologic Stage IIA-IIIC Triple-Negative Breast Cancer

    phase 1 mab active

    1 trial
  6. Ξ³Ξ΄T Cell infusion agent

    The First People's Hospital of Lianyungang

    Leukemia, B-cell

    phase 1 small molecule active

    1 trial
  7. ​​A Phase 1, Open-Label, Multiple-Part Trial to Evaluate the Drug-Drug Interaction Potential of PRAX-628 in Healthy Participants​

    Chongqing Precision Biotech Co., Ltd

    Epilepsy

    phase 1 other active

    1 trial
  8. ​​AMG 436 as monotherapy and combination therapy in participants with Microsatellite Instability-High/Mismatch Repair Deficient Solid Tumors ​

    Amgen

    microsatellite instability high/mismatch repair deficient (MSI-H/dMMR) solid tumors

    phase 1 other active

    1 trial
  9. β€žINSIGHTβ€œ An explorative, open-labeled, phase I trial to evaluate feasibility and safety of eftilagimod alpha (IMP321, a LAG-3Ig fusion protein acting as LAG-3 agonist) in combination with immunotherapeutic, targeted or chemotherapeutic agents or when administered via new routes of application in advanced stage solid tumors

    The George Institute

    Histologically confirmed locally advanced or metastatic solid tumor (Strata A, B, D): Specification for Stratum C: Only patients with NSCLC adenocarcinomas, (squamous or adenosquamous not permitted) who are scheduled to receive platin + pembrolizumab + pemetrexed standard treatment (only for Stratum C) Specification for Stratum E: Including only metastatic or irresectable locally advanced urothelial carcinomas (only for Stratum E)

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources Β· All pipeline programs