Intelligence · Clinical Pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs: 7,238

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

"Endostar"

The First People's Hospital of Lianyungang

Esophageal

phase 2 small molecule terminated

1 trial
(+)-α-DIHYDROTETRABENAZINE

Lacuna Pharma Pty Ltd

Tardive dyskinesia

phase 2 small molecule active

1 trial
(+)-α-DIHYDROTETRABENAZINE

Lacuna Pharma Pty Ltd

tardive dyskinesia

phase 2 small molecule active

1 trial
(+)-α-DIHYDROTETRABENAZINE, ADE513 placebo

Lacuna Pharma Pty Ltd

Tardive dyskinesia

phase 2 small molecule active

1 trial
(Z)-endoxifen

ATOSSA THERAPEUTICS, INC.

Breast Neoplasms

phase 2 small molecule active

1 trial
-

Disc Medicine

Intrahepatic cholangiocarcinoma (iCCA)

phase 2 small molecule active

1 trial
-

The George Institute

Cytomegalovirus infection post allogeneic allogeneic HLA-identical familial PHT

phase 2 small molecule active

1 trial
-

Ningbo Cancer Hospital

Unresectable intrahepatic cholangiocarcinoma

phase 2 small molecule active

1 trial
-

Talion

Primary or advanced breast cancer LumA or ER+ Lobular subtypes.

phase 2 small molecule active

1 trial
-

Lacuna Pharma Pty Ltd

Myocardial Infarction, Acute Heart Failure, Left Sided

phase 2 small molecule active

1 trial
-, -, -, MK-1200, -, -

Merck Sharp and Dohme

Advanced solid tumor

phase 2 small molecule active

1 trial
-, -, CIMETIDINE , ROXATIDINE , FAMOTIDINE, COMBINATIONS, PARACETAMOL , RANITIDINE , NIZATIDINE , SKB264, FAMOTIDINE , -

Lacuna Pharma Pty Ltd

Metastatic or locally advanced unresectable solid tumors progressing after available standard therapies

phase 2 small molecule active

1 trial
-, -, PACLITAXEL , MK-2870, -, MK-1022, RAMUCIRUMAB , MK-2870, PARACETAMOL

Merck Sharp and Dohme

Gastroesophageal cancer

phase 2 small molecule active

1 trial
-, -, ROXATIDINE , RANITIDINE , OSIMERTINIB , NIZATIDINE , SKB264, CIMETIDINE , FAMOTIDINE, COMBINATIONS, FAMOTIDINE , CARBOPLATIN , PARACETAMOL , PEMBROLIZUMAB , OSIMERTINIB, -

Lacuna Pharma Pty Ltd

Advanced or Metastatic Non-small Cell Lung Cancer

phase 2 small molecule active

1 trial
-, ABIRATERONE, DEGARELIX, RELUGOLIX, APALUTAMIDE, ABIRATERONE, ENZALUTAMIDE, ENZALUTAMIDE, ENZALUTAMIDE, AAA802, AAA502, Locametz 25 micrograms kit for radiopharmaceutical preparation, DEGARELIX ACETATE, DAROLUTAMIDE

Novartis Pharmaceuticals

PSMA-positive metastatic hormone sensitive prostate cancer (mHSPC) and metastatic Castration-resistant Prostate Cancer (mCRPC) with or without prior 177Lu-PSMA radioligand therapy.

phase 2 small molecule active

1 trial
-, CYCLOPHOSPHAMIDE, Cesnicabtagene autoleucel, PARACETAMOL, FLUDARABINE, LENALIDOMIDE, RoActemra 20 mg/mL concentrate for solution for infusion

The George Institute

Plasma cell leukaemia

phase 2 small molecule active

1 trial
-, DNL593 Placebo, Sterile lyophilisate in single-dose glass vials, -, FAMOTIDINE

Denali Therapeutics

Frontotemporal Dementia (FTD)

phase 2 small molecule active

1 trial
-, MERCAPTOPURINE , -, Film-Coated Tablet without JNJ-77242113, JNJ-77242113, AZATHIOPRINE , METHOTREXATE , JNJ-77242113

Janssen-Cilag International N.V.

Ulcerative Colitis

phase 2 small molecule active

1 trial
-, PREDNISONE, PARACETAMOL , FLUDROCORTISONE , ABIRATERONE , -, HYDROCORTISONE, -, Ifinatamab Deruxtecan, -, -, HYDROCORTISONE, HYDROCORTISONE, Opevesostat, DOCETAXEL , ENZALUTAMIDE , PREDNISOLONE

Merck Sharp and Dohme

Metastatic castrate resistant prostate cancer - mCRPC

phase 2 small molecule active

1 trial
-, Pred Forte 10 mg/ml colirio en suspensión

AbbVie Deutschland GmbH & Co. KG

platinum-resistant advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers.

phase 2 small molecule active

1 trial
-, RIVAROXABAN, RIVAROXABAN

Pari Pharma GmbH

newly diagnosed or relapsing deep venous thrombosis related to Behçet’s syndrome

phase 2 small molecule active

1 trial
-, Raludotatug Deruxtecan, MK-4830, MK-1308A, KEYTRUDA 25 mg/mL concentrate for solution for infusion, Lenvatinib, Lenvatinib, MK-4280A, DEXAMETHASONE , APREPITANT

Merck Sharp and Dohme

Participants with extensive-stage small cell lung cancer

phase 2 small molecule active

1 trial
-aminosalicylic acid

Ultragenyx UK Limited

Ulcerative Colitis

phase 2 small molecule completed

1 trial
0% N2O

BRIGHT MINDS BIOSCIENCES INC.

Opioid-Related Disorders

phase 2 small molecule completed

2 trials
0.2mg group

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Opioid Dependence

phase 2 small molecule active

1 trial
0.5% Ivermectin lotion

United Therapeutics Europe Ltd

Pediculosis Capitis

phase 2 small molecule completed

1 trial
0.59 mg fluocinolone acetonide intravitreal implant

Bausch & Lomb Incorporated

Diabetic Macular Edema

phase 2 small molecule completed

1 trial
0.9% NaCl 2000ml

Universal Integrated

Brain Infarct

phase 2 small molecule completed

1 trial
0.9% Sodium Chloride Injection

GlaxoSmithKline

Non-alcoholic Fatty Liver Disease

phase 2 small molecule active

1 trial
0.9% Sodium Chloride Injection, mRNA-3705

Moderna Biotech Spain

Isolated Methylmalonic Acidemia Due to Methylmalonyl-CoA Mutase Deficiency

phase 2 small molecule active

1 trial
0.9% Sodium Chloride for Injection (Fresenius Kab) sourced locally by sites, AP-101

Lacuna Pharma Pty Ltd

Amyotrophic Lateral Sclerosis (ALS)

phase 2 small molecule active

1 trial
0.9% Sodium chloride - inhalation solution

Arrowhead Pharmaceuticals Ireland Limited

Inflammatory Lung Disease

phase 2 small molecule active

1 trial
0.9% sodium chloride

The First People's Hospital of Lianyungang

Kidney Disease, Chronic

phase 2 small molecule active

1 trial
0.9% sodium chloride - inhalation solution, ARO-MUC5AC Inhalation Solution

Arrowhead Pharmaceuticals Ireland Limited

Asthma and Chronic obstructive pulmonary disease

phase 2 small molecule active

1 trial
0.9% sodium chloride aqueous solution for IV infusion

Chiesi Farmaceutici S.p.A

Idiopathic pulmonary fibrosis (IPF)

phase 2 small molecule active

1 trial
0.9% sodium chloride, GADOTERIC ACID

Eli Lilly Co.

Relapsing Multiple Sclerosis

phase 2 small molecule active

1 trial
00 mg/mL Concentrate for solution for infusion, VHB937

Novartis Pharmaceuticals

Alzheimer’s disease

phase 2 small molecule active

1 trial
1% tenofovir gel

BRIGHT MINDS BIOSCIENCES INC.

HIV Infections

phase 2 small molecule completed

1 trial
1-(3-(fluoro-18F)benzyl)guanidine ([18F]mFBG)

Disc Medicine

Pheochromocytoma – endocrine adrenal tumor

phase 2 small molecule active

1 trial
1. Intranasal oxytocin spray

United Therapeutics Europe Ltd

Autism Spectrum Disorder

phase 2 small molecule active

1 trial
10 GE Xenokidney

United Therapeutics Europe Ltd

ESRD (End-Stage Renal Disease)

phase 2 mab active

1 trial
10 mg PRAX-114

Chongqing Precision Biotech Co., Ltd

Major Depressive Disorder

phase 2 small molecule completed

1 trial
10 mg PRAX-114

Praxis Precision Medicines

Major Depressive Disorder

phase 2 small molecule completed

1 trial
10 mg PRAX-114, 20 mg PRAX-114, and Placebo

Chongqing Precision Biotech Co., Ltd

Essential Tremor

phase 2 small molecule terminated

1 trial
10 mg/kg CM-101

Chemomab Therapeutics

Systemic Sclerosis

phase 2 small molecule on hold

1 trial
100 mg PRAX-944

Chongqing Precision Biotech Co., Ltd

Essential Tremor

phase 2 small molecule completed

1 trial
100 μg KIO-301

KIORA PHARMACEUTICALS INC

Retinitis Pigmentosa

phase 2 small molecule active

1 trial
100U EV71 vaccine with adjuvant

Sinovac Research and Development Co.,

Infection, Viral, Enterovirus

phase 2 mab completed

1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

Quick answer

Top sponsors

"Endostar"

(+)-α-DIHYDROTETRABENAZINE

(+)-α-DIHYDROTETRABENAZINE

(+)-α-DIHYDROTETRABENAZINE, ADE513 placebo

(Z)-endoxifen

-

-

-

-

-

-, -, -, MK-1200, -, -

-, -, CIMETIDINE , ROXATIDINE , FAMOTIDINE, COMBINATIONS, PARACETAMOL , RANITIDINE , NIZATIDINE , SKB264, FAMOTIDINE , -

-, -, PACLITAXEL , MK-2870, -, MK-1022, RAMUCIRUMAB , MK-2870, PARACETAMOL

-, -, ROXATIDINE , RANITIDINE , OSIMERTINIB , NIZATIDINE , SKB264, CIMETIDINE , FAMOTIDINE, COMBINATIONS, FAMOTIDINE , CARBOPLATIN , PARACETAMOL , PEMBROLIZUMAB , OSIMERTINIB, -

-, ABIRATERONE, DEGARELIX, RELUGOLIX, APALUTAMIDE, ABIRATERONE, ENZALUTAMIDE, ENZALUTAMIDE, ENZALUTAMIDE, AAA802, AAA502, Locametz 25 micrograms kit for radiopharmaceutical preparation, DEGARELIX ACETATE, DAROLUTAMIDE

-, CYCLOPHOSPHAMIDE, Cesnicabtagene autoleucel, PARACETAMOL, FLUDARABINE, LENALIDOMIDE, RoActemra 20 mg/mL concentrate for solution for infusion

-, DNL593 Placebo, Sterile lyophilisate in single-dose glass vials, -, FAMOTIDINE

-, MERCAPTOPURINE , -, Film-Coated Tablet without JNJ-77242113, JNJ-77242113, AZATHIOPRINE , METHOTREXATE , JNJ-77242113

-, PREDNISONE, PARACETAMOL , FLUDROCORTISONE , ABIRATERONE , -, HYDROCORTISONE, -, Ifinatamab Deruxtecan, -, -, HYDROCORTISONE, HYDROCORTISONE, Opevesostat, DOCETAXEL , ENZALUTAMIDE , PREDNISOLONE

-, Pred Forte 10 mg/ml colirio en suspensión

-, RIVAROXABAN, RIVAROXABAN

-, Raludotatug Deruxtecan, MK-4830, MK-1308A, KEYTRUDA 25 mg/mL concentrate for solution for infusion, Lenvatinib, Lenvatinib, MK-4280A, DEXAMETHASONE , APREPITANT

-aminosalicylic acid

0% N2O

0.2mg group

0.5% Ivermectin lotion

0.59 mg fluocinolone acetonide intravitreal implant

0.9% NaCl 2000ml

0.9% Sodium Chloride Injection

0.9% Sodium Chloride Injection, mRNA-3705

0.9% Sodium Chloride for Injection (Fresenius Kab) sourced locally by sites, AP-101

0.9% Sodium chloride - inhalation solution

0.9% sodium chloride

0.9% sodium chloride - inhalation solution, ARO-MUC5AC Inhalation Solution

0.9% sodium chloride aqueous solution for IV infusion

0.9% sodium chloride, GADOTERIC ACID

00 mg/mL Concentrate for solution for infusion, VHB937

1% tenofovir gel

1-(3-(fluoro-18F)benzyl)guanidine ([18F]mFBG)

1. Intranasal oxytocin spray

10 GE Xenokidney

10 mg PRAX-114

10 mg PRAX-114

10 mg PRAX-114, 20 mg PRAX-114, and Placebo

10 mg/kg CM-101

100 mg PRAX-944

100 μg KIO-301

100U EV71 vaccine with adjuvant

Frequently asked questions

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