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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 40 of 99

  1. EXPAREL

    Pacira Ireland Limited

    Healthy

    phase 1 small molecule terminated

    1 trial

  2. EXPAREL

    Pacira Ireland Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  3. EXS73565

    RECURSION PHARMACEUTICALS, INC.

    Relapsed or Refractory B-cell Malignancies

    phase 1 small molecule active

    1 trial

  4. EXS74539

    RECURSION PHARMACEUTICALS, INC.

    Solid Tumor

    phase 1 small molecule active

    1 trial

  5. EXT608

    Universal Integrated

    Safety Issues

    phase 1 small molecule completed

    1 trial

  6. Ebola Vaccine - low dose

    United Therapeutics Europe Ltd

    Ebola Virus Disease

    phase 1 mab completed

    1 trial

  7. Effect of Erythromycin on the absorption, metabolism and elimination of CHF6001 in healthy volunteers

    Chiesi Farmaceutici S.p.A

    This study is a phase I trial to investigate the effect of inhibition of CYP3A4/5 by Erythromycin on the pharmacokinetics of CHF6001 in healthy volunteers.

    phase 1 other active

    1 trial

  8. Effect of NBI-921355 on corticospinal excitability in healthy participants

    NEUROCRINE BIOSCIENCES INC

    Epilepsy

    phase 1 other active

    1 trial

  9. Effect of Renal Impairment on Enpatoran Pharmacokinetics

    Merck Sharp and Dohme

    Healthy volunteers and patients with renal impairment; Intended indication: autoimmune diseases; systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE), as well as dermatomyositis (DM) and polymyositis (PM).

    phase 1 other active

    1 trial

  10. Effect of SAR445611 on inflammatory responses following LPS challenge study in healthy participants

    Sanofi-aventis Healthcare Pty Ltd

    Immune system diseases

    phase 1 other active

    1 trial

  11. Efficacy of LCAR-T2C CAR-T cells

    Nanjing Legend Biotech Co.

    CD4+ T Lymphocyte Tumor (T Cell Lymphoma and T Cell Leukemia)

    phase 1 small molecule terminated

    1 trial

  12. Efficacy of LCAR-T2C CAR-T cells

    Nanjing Legend Biotech Co.

    T Cell Lymphoma

    phase 1 small molecule terminated

    1 trial

  13. Elagolix

    NEUROCRINE BIOSCIENCES INC

    Folliculogenesis

    phase 1 small molecule completed

    1 trial

  14. Electroporation-Mediated Plasmid DNA Vaccine Therapy

    INOVIO PHARMACEUTICALS, INC.

    Chronic Hepatitis

    phase 1 mab active

    1 trial

  15. Elimusertib (BAY1895344)

    Bayer HealthCare AG

    Advanced Solid Tumor

    phase 1 small molecule completed

    1 trial

  16. Eltanexor

    Karyopharm Therapeutics Inc

    Relapsed Myelodysplastic Syndrome

    phase 1 small molecule active

    1 trial

  17. Empagliflozin 10 MG Oral Tablet [Jardiance]

    BRIGHT MINDS BIOSCIENCES INC.

    Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  18. Emtricitabine

    United Therapeutics Europe Ltd

    HIV

    phase 1 small molecule completed

    1 trial

  19. Encapsulated Calcium

    United Therapeutics Europe Ltd

    Pregnancy

    phase 1 other completed

    1 trial

  20. Endo Tool

    United Therapeutics Europe Ltd

    Burns

    phase 1 other completed

    1 trial

  21. Engineered mitochondrial vaccine

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Advanced Solid Tumor Malignancies

    phase 1 mab active

    1 trial

  22. Entinostat

    Syndax Pharmaceuticals

    Neoplasms

    phase 1 small molecule completed

    2 trials

  23. Entinostat

    Syndax Pharmaceuticals

    Volunteers

    phase 1 small molecule completed

    2 trials

  24. Entinostat

    Syndax Pharmaceuticals

    Pancreas Cancer

    phase 1 small molecule terminated

    1 trial

  25. Entinostat

    Syndax Pharmaceuticals

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  26. Entinostat

    Syndax Pharmaceuticals

    Metastatic Breast Cancer

    phase 1 small molecule completed

    1 trial

  27. Entinostat

    Syndax Pharmaceuticals

    Fallopian Tube Cancer

    phase 1 small molecule terminated

    1 trial

  28. Entinostat

    Syndax Pharmaceuticals

    Drug Interaction

    phase 1 small molecule completed

    1 trial

  29. Enzalutamide

    CORCEPT THERAPEUTICS INC

    Prostate Cancer

    phase 1 small molecule completed

    1 trial

  30. Epetraborole

    AN2 Therapeutics

    Renal Insufficiency

    phase 1 small molecule completed

    1 trial

  31. Epetraborole

    AN2 Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  32. Epetraborole and matching placebo

    AN2 Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  33. Epidiolex

    BRIGHT MINDS BIOSCIENCES INC.

    CBD

    phase 1 small molecule active

    1 trial

  34. Epidiolex 100 mg/mL Oral Solution

    Jazz Pharmaceuticals Ireland Limited

    Electrical Status Epilepticus of Slow-Wave Sleep

    phase 1 small molecule completed

    1 trial

  35. Eplontersen

    IONIS PHARMACEUTICALS INC

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  36. Eprolidone

    The First People's Hospital of Lianyungang

    Chronic Heart Failure Patients

    phase 1 small molecule active

    1 trial

  37. Erwinase

    Jazz Pharmaceuticals Ireland Limited

    Acute Lymphoblastic Leukemia

    phase 1 small molecule completed

    1 trial

  38. Erwinia Chrysanthemi asparaginase

    Jazz Pharmaceuticals Ireland Limited

    Acute Lymphoblastic Leukemia (ALL)

    phase 1 small molecule terminated

    1 trial

  39. EryDex (dexamethasone sodium phosphate encapsulated erythrocytes)

    Quince Therapeutics

    Healthy

    phase 1 small molecule completed

    1 trial

  40. Erythromycin lactobionate

    ADIAL PHARMACEUTICALS, INC.

    Diabetes Mellitus, Type 1

    phase 1 small molecule completed

    1 trial

  41. Escitalopram

    Universal Integrated

    Major Depressive Disorder

    phase 1 small molecule completed

    1 trial

  42. Esketamine injection group (0.25 mg/kg)

    The First People's Hospital of Lianyungang

    Esketamine

    phase 1 small molecule active

    1 trial

  43. Esomeprazole Capsule

    Takeda

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  44. Estradiol/Norethindrone acetate

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  45. Etanercept

    United Therapeutics Europe Ltd

    Gulf War Illness

    phase 1 small molecule active

    1 trial

  46. Ethinyl Estradioll/Levonorgestrel (EE/LNG)

    Atea Pharmaceuticals

    Healthy Volunteer Study

    phase 1 small molecule completed

    1 trial

  47. Etrasimod Arginine Blue

    Pfizer Australia Pty Ltd

    Ulcerative Colitis and immune-mediated inflammatory disorders

    phase 1 small molecule active

    1 trial

  48. Etripamil Nasal Spray 70mg

    Milestone Pharmaceuticals

    Healthy Chinese Subjects

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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