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Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

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NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

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  1. Etrumadenant

    Arcus Biosciences

    Healthy Participants

    phase 1 small molecule completed

    2 trials

  2. Etrumadenant

    Arcus Biosciences

    Non Small Cell Lung Cancer Metastatic

    phase 1 small molecule completed

    1 trial

  3. Etrumadenant

    Arcus Biosciences

    TNBC - Triple-Negative Breast Cancer

    phase 1 small molecule completed

    1 trial

  4. Etrumadenant

    Arcus Biosciences

    Non-small Cell Lung Cancer

    phase 1 small molecule completed

    1 trial

  5. Evaluate the effects of Environmental Enrichment (EE) on alcohol consumption

    BRIGHT MINDS BIOSCIENCES INC.

    Alcohol Use Disorder

    phase 1 other active

    1 trial

  6. Evaluating Bioequivalence of a Fixed Dose Combination versus Individual Tablets of Bempedoic Acid / Ezetimibe, and Atorvastatin.

    Daiichi Sankyo

    No medical condition.

    phase 1 other active

    1 trial

  7. Evaluating Bioequivalence of a Fixed Dose Combination versus Individual Tablets of Bempedoic Acid, Ezetimibe, and Atorvastatin.

    Daiichi Sankyo

    No medical condition.

    phase 1 other active

    1 trial

  8. Evaluating Bioequivalence of a Fixed Dose Combination versus Individual Tablets of Bempedoic Acid, Ezetimibe, and Rosuvastatin.

    Daiichi Sankyo

    No medical condition

    phase 1 other active

    1 trial

  9. Evaluating Bioequivalence of a Fixed Dose Combination versus Tablets of Bempedoic Acid / Ezetimibe and Rosuvastatin.

    Daiichi Sankyo

    No medical condition.

    phase 1 other active

    1 trial

  10. Evaluating PD-1/PD-L1 in rectal cancer by quantitative fluorescence molecular endoscopy.

    Disc Medicine

    Locally advanced rectal cancer

    phase 1 other active

    1 trial

  11. Evaluation of AG-181 in Subjects 18 to 69 Years of Age With Phenylketonuria

    Lacuna Pharma Pty Ltd

    Phenylketonuria

    phase 1 other active

    1 trial

  12. Evaluation of bioequivalence of two products containing 400 mg ibuprofen and 100 mg caffeine: Ibuprofen / Caffeine 400 mg / 100 mg coated granules (Test) vs. Thomapyrin TENSION DUO, 400mg / 100mg Filmtabletten (Reference). A monocentric, open, randomized, single dose, two-period, crossover trial in healthy volunteers

    Lacuna Pharma Pty Ltd

    No therapeutic indication in the current trial with healthy volunteers.

    phase 1 other active

    1 trial

  13. Evaluation of bioequivalence of two products containing 50 mg dimenhydrinate: Dimenhydrinate 50 mg (Test) vs. Vomex A 50 mg Lösung zum Einnehmen im Beutel (Comparator). A monocentric, open, randomized, single dose, two-period, crossover trial in healthy volunteers

    Lacuna Pharma Pty Ltd

    No therapeutic indication in the current trial with healthy volunteers.

    phase 1 other active

    1 trial

  14. Evaluation of bioequivalence of two products containing 600 mg ibuprofen: Ibuprofen Sopharma 600 mg film-coated tablets (Test) vs. Brufen 600 mg film-coated tablets (Comparator). A monocentric, open, randomized, single dose, two-period, crossover trial in healthy volunteers

    Lacuna Pharma Pty Ltd

    No therapeutic indication in the current trial with healthy volunteers.

    phase 1 other active

    1 trial

  15. Evaluation of safety, side effects and how the drug CHF6467 administrated via intranasal route is absorbed, modified and removed in healthy subjects.

    Chiesi Farmaceutici S.p.A

    Neonatal Hypoxic-Ischemic Encephalopathy (HIE), Neonatal Hypoxic-Ischemic Encephalopathy (HIE)

    phase 1 other active

    1 trial

  16. Evaluation of safety, side effects and how the inhaled drug CHF10073 is absorbed, modified and removed from the body when administered alone or in combination with itraconazole in male and female healthy adults

    Chiesi Farmaceutici S.p.A

    Pulmonary fibrosis

    phase 1 other active

    1 trial

  17. Evaluation of the CHF 5993 concentration in blood, after inhalation with two different devices, (NEXThaler® versus pMDI), with and without Aerochamber spacer device, in healthy volunteers.

    Chiesi Farmaceutici S.p.A

    Asthma

    phase 1 other active

    1 trial

  18. Evaluation of the Effect of Food, Itraconazole, and Rifampicin on the Single-Dose Pharmacokinetics of Naronapride.

    Dr. Falk Pharma GmbH

    No medical condition.

    phase 1 other active

    1 trial

  19. Evaluation of the Effect of Itraconazole, Quinidine and Rifampicin on the Single-Dose Pharmacokinetics of ZED1227

    Dr. Falk Pharma GmbH

    No medical condition.

    phase 1 other active

    1 trial

  20. Evaluation of the Novel Therapeutic Hepatitis B Virus Synthetic Long Peptide Vaccination ISA104 (HEB-PEP)

    Disc Medicine

    chronic Hepatitis B

    phase 1 other active

    1 trial

  21. Evaluation of the bioavailability of two transdermal gel preparations containing 0.1% w/w estradiol under fasting conditions: Estradiol/INTERMED gel 0.1% w/w (Test) vs. ESTREVA® 0.1%, gel (Comparator). A monocentric, open, randomized, single dose, two-period, crossover trial in healthy postmenopausal women

    Lacuna Pharma Pty Ltd

    No therapeutic indication in the current trial with healthy volunteers.

    phase 1 other active

    1 trial

  22. Evaluation of the effect of CHF6795 on the pharmacokinetics of midazolam, repaglinide and rosuvastatin in healthy subjects

    Chiesi Farmaceutici S.p.A

    Chronic cough

    phase 1 other active

    1 trial

  23. Evaluation of vamorolone CYP3A4 induction on midazolam (a sensitive CYP3A4 substrate) pharmacokinetics

    Lacuna Pharma Pty Ltd

    Phase I study in healthy male volunteers. Intended indication: Duchenne muscular dystrophy and Becker muscular dystrophy

    phase 1 other active

    1 trial

  24. Evinacumab

    Regeneron UK Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  25. Evixapodlin

    Gilead Sciences Ireland UC

    Advanced Solid Tumors

    phase 1 small molecule terminated

    1 trial

  26. Evolocumab

    BRIGHT MINDS BIOSCIENCES INC.

    Healthy Subjects

    phase 1 mab completed

    1 trial

  27. Evorpacept

    ALX ONCOLOGY HOLDINGS INC

    Bladder Cancer

    phase 1 small molecule completed

    1 trial

  28. Evorpacept (ALX148)

    ALX ONCOLOGY HOLDINGS INC

    Metastatic Cancer

    phase 1 small molecule completed

    1 trial

  29. Ex-vivo expanded allogeneic γδ T cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    AML (Acute Myelogenous Leukemia)

    phase 1 mab active

    1 trial

  30. Ex-vivo expanded allogeneic γδT cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Non-Hodgkin's Lymphoma (NHL)

    phase 1 mab active

    1 trial

  31. Exenatide Circular RNA-Lipid Nanoparticle Injection（ CR059））

    The First People's Hospital of Lianyungang

    T2DM

    phase 1 small molecule active

    1 trial

  32. Exparel Injectable Product

    Pacira Ireland Limited

    Breast Augmentation

    phase 1 small molecule completed

    1 trial

  33. Exparel Injectable Product

    Pacira Ireland Limited

    Bunion

    phase 1 small molecule completed

    1 trial

  34. Experimental Vaccine 1

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    COVID-19 Pneumonia

    phase 1 mab completed

    1 trial

  35. ExplOratory, Phase 0 Study to assess biodisTribution and PosItron EMission Tomography (PET) Imaging kinetics of [64Cu]Cu-PSMA-R2 in metaStatic prostate cancEr patients

    CERO THERAPEUTICS HOLDINGS, INC.

    metastatic prostate cancer

    phase 1 other active

    1 trial

  36. Exploratory Bioavailability of Three Formulations of Gliclazide MR Tablets 120 mg (I.R.I.S.) in Healthy Volunteers Under Fed Conditions (High Fat High Calorie Meal and Standard Meal).

    The George Institute

    No medical condicion.

    phase 1 other active

    1 trial

  37. Exploratory study to assess the pharmacokinetic interaction of doxepin with adrenaline after a concomitant co-administration using the Anapen® device and to compare the adrenaline comparative bioavailability with Anapen®500 commercial form in healthy normal weight male subjects

    Bioprojet Pharma

    Anaphylaxis

    phase 1 other active

    1 trial

  38. Exposure to sporting events

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Coronary Heart Disease

    phase 1 other completed

    1 trial

  39. External non-invasive stimulation

    United Therapeutics Europe Ltd

    TBI (Traumatic Brain Injury)

    phase 1 other active

    1 trial

  40. Extracellular Vesicles from Mesenchymal Stem Cells

    Regeneron Ireland Designated Activity Company (DAC)

    COVID-19 Pneumonia

    phase 1 mab active

    1 trial

  41. Extraluminal use of Univent bronchial Blocker

    Hospital Authority, Hong Kong

    Therapeutic Procedural Complication

    phase 1 other completed

    1 trial

  42. F2F

    BRIGHT MINDS BIOSCIENCES INC.

    Prescription Stimulant Misuse

    phase 1 other active

    1 trial

  43. FATE-NK100

    Zafatek

    HER2 Positive Gastric Cancer

    phase 1 small molecule completed

    1 trial

  44. FAVICOVIR 200 mg Film Tablet

    BRIGHT MINDS BIOSCIENCES INC.

    Bioequivalence

    phase 1 small molecule completed

    1 trial

  45. FAVIR 200 MG FT

    BRIGHT MINDS BIOSCIENCES INC.

    Bioequivalence

    phase 1 small molecule completed

    1 trial

  46. FB102

    Forteo

    Vitiligo

    phase 1 small molecule active

    1 trial

  47. FB102

    Forteo

    Alopecia Areata

    phase 1 small molecule active

    1 trial

  48. FGI-101-1A6

    United Therapeutics Europe Ltd

    Influenza

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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