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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 1 of 99

  1. "A study in healthy people to test how 2 different formulations of a combination treatment (vicadrostat and empagliflozin) are taken up in the body and how food influences the amount of the medicines in the blood"

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  2. "A study to test how well BI 3000202 is tolerated by people with type 1 interferonopathies"

    Boehringer Ingelheim

    Type 1 interferonopathies

    phase 1 other active

    1 trial

  3. (+)-SJ000557733

    CNS Pharmaceuticals

    Plasmodium Falciparum Malaria

    phase 1 small molecule completed

    1 trial

  4. (22597) A study to learn about how safe nitroglycerin is and how it affects the body when taken along with nurandociguat in people with coronary artery disease.

    Bayer AG

    Chronic kidney disease, Coronary artery disease

    phase 1 other active

    1 trial

  5. 1 Nalmefene implant

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Abuse and Addiction

    phase 1 small molecule active

    1 trial

  6. 1 mg/kg GR-MD-02

    GALECTIN THERAPEUTICS INC

    Metastatic Melanoma

    phase 1 mab completed

    1 trial

  7. 1% icotinib hydrochloride cream

    Betta Pharmaceuticals Co.,

    Psoriasis

    phase 1 small molecule completed

    1 trial

  8. 100 mg Delamanid

    Otsuka Beijing Research Institute

    Multidrug Resistant Tuberculosis

    phase 1 small molecule completed

    1 trial

  9. 100 mg GLPG1205

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule completed

    1 trial

  10. 100 mg Resmetirom Tablet

    Madrigal Pharmaceuticals EU Limited

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  11. 100 mg dose of [14C] GLPG0634

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule completed

    1 trial

  12. 100U inactivated Enterovirus Type 71 Vaccine

    Sinovac Research and Development Co.,

    Hand-foot-mouth Disease

    phase 1 mab completed

    1 trial

  13. 11-valent recombinant human papilloma virus vaccine (Hansenula polymorpha)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    HPV Infection

    phase 1 mab completed

    1 trial

  14. 11C-OMAR

    BRIGHT MINDS BIOSCIENCES INC.

    Cannabis Use Disorder

    phase 1 small molecule completed

    1 trial

  15. 124I-labeled monoclonal antibody Mu 11-1F4

    BRIGHT MINDS BIOSCIENCES INC.

    AL Amyloidosis

    phase 1 mab completed

    1 trial

  16. 131I-IPA

    Telix Innovations

    Neoplastic Disease

    phase 1 small molecule active

    1 trial

  17. 131I-apamistmab

    Actinium Pharmaceuticals

    Sickling Disorder Due to Hemoglobin S

    phase 1 small molecule active

    1 trial

  18. 14028 injection

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Type 2 Diabetes

    phase 1 mab completed

    1 trial

  19. 145 mg/m2 NKTR 102

    Nektar Therapeutics UK Limited

    Advanced or Metastatic Solid Tumors in Patients With Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  20. 14C-CORT125281

    CORCEPT THERAPEUTICS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  21. 14C-VX-993

    Vertex Pharmaceuticals (Australia) Pty.

    Pain

    phase 1 small molecule completed

    1 trial

  22. 14C-XEN1101

    Xenon Pharmaceuticals

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  23. 15-Valent Pneumococcal Conjugate Vaccine

    BRIGHT MINDS BIOSCIENCES INC.

    Pneumonia, Pneumococcal

    phase 1 mab active

    1 trial

  24. 153Sm-DOTMP

    Telix Innovations

    Bone Pain

    phase 1 small molecule active

    1 trial

  25. 15NH4Cl, Sodium Chloride for injection, [13C]Sodium Acetate, CMP-CPS-001

    Camp4 Therapeutics Corp

    Urea cycle disorders (UCD)

    phase 1 small molecule active

    1 trial

  26. 15O-WATER, Natriumklorid Fresenius Kabi, 9 mg/ml, infusionsvätska, lösning, AZD3427, Dopamin Fresenius 50 mg/5 ml, Konzentrat zur Herstellung einer Infusionslösung, Placebo for AZD3427 or AZD3427 diluent

    AstraZeneca AB

    Heart failure with reduced ejection fraction, Renal impairment

    phase 1 small molecule active

    1 trial

  27. 177Lu-DOTA-TLX591

    Telix Innovations

    Metastatic Prostate Cancer

    phase 1 mab completed

    1 trial

  28. 177Lu-TLX250 and Peposertib

    Telix Innovations

    Solid Tumor, Adult

    phase 1 other active

    1 trial

  29. 18F-FAPIBiotin

    The First People's Hospital of Lianyungang

    Malignant Neoplasm

    phase 1 small molecule active

    1 trial

  30. 18F-FDG

    The First People's Hospital of Lianyungang

    Multiple Myeloma and Malignant Plasma Cell Neoplasms

    phase 1 small molecule active

    1 trial

  31. 18F-PEG6-IPQA

    United Therapeutics Europe Ltd

    Lung Cancer

    phase 1 small molecule completed

    1 trial

  32. 19(T2)28z1xx CAR T cells

    Takeda

    Diffuse Large B Cell Lymphoma

    phase 1 small molecule active

    1 trial

  33. 19(T2)28z1xx TRAC T cell

    Takeda

    B-Cell Lymphoma

    phase 1 mab active

    1 trial

  34. 1mg KHK7580

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  35. 2-4 of the drugs listed below

    BRIGHT MINDS BIOSCIENCES INC.

    Drug Dependence

    phase 1 small molecule completed

    1 trial

  36. 2-4 of the drugs listed below

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Dependence

    phase 1 small molecule completed

    1 trial

  37. 20 mg/kg TRU-016 + Rituximab

    Aptevo Therapeutics

    Chronic Lymphocytic Leukemia

    phase 1 mab terminated

    1 trial

  38. 200 mg GLPG0634 as capsules, fasted

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule completed

    1 trial

  39. 250 mg capsule

    LEXICON PHARMACEUTICALS, INC.

    Irritable Bowel Syndrome

    phase 1 small molecule completed

    1 trial

  40. 25mcg rhPTH(1-84)

    Takeda

    Hypoparathyroidism

    phase 1 small molecule completed

    1 trial

  41. 2X-121 and dovitinib

    Allarity Therapeutics

    Advanced Solid Tumors

    phase 1 small molecule on hold

    1 trial

  42. 2mg INO-5150 and electroporation device CELLECTRA®-5P

    INOVIO PHARMACEUTICALS, INC.

    Prostate Cancer

    phase 1 mab completed

    1 trial

  43. 3-dimensional conformal radiation therapy

    United Therapeutics Europe Ltd

    Bladder Cancer

    phase 1 other active

    1 trial

  44. 30 mg dexlansoprazole capsules manufactured at TOB

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  45. 300 mg LX4211 (150 mg tablets)

    LEXICON PHARMACEUTICALS, INC.

    Type 2 Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  46. 300 mg [C14] CT1812

    COGNITION THERAPEUTICS INC

    Alzheimer Disease

    phase 1 small molecule completed

    1 trial

  47. 304 injection

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    CD20 Positive B Cell NHL

    phase 1 small molecule active

    1 trial

  48. 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one

    BRIGHT MINDS BIOSCIENCES INC.

    Cannabis Abuse

    phase 1 small molecule terminated

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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