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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. Cemiplimab

    Regeneron UK Limited

    Lung Cancer

    phase 1 small molecule active

    1 trial

  2. Cemiplimab-Rwlc

    Regeneron UK Limited

    Merkel Cell Carcinoma

    phase 1 small molecule active

    1 trial

  3. Cemsidomide

    C4 Therapeutics

    Multiple Myeloma (MM)

    phase 1 small molecule active

    1 trial

  4. Ceralasertib

    AstraZeneca

    Advanced Solid Malignancies

    phase 1 small molecule completed

    1 trial

  5. Ceralasertib, IMFINZI 50 mg/mL concentrate for solution for infusion, INFLIXIMAB, MYCOPHENOLATE MOFETIL, AZD4773, IMJUDO 20 mg/ml concentrate for solution for infusion.

    AstraZeneca AB

    • Non-small cell lung cancer (Stage III, unresectable) • Small cell lung cancer (Limited stage) • Hepatocellular carcinoma (Unresectable) • Advanced or Metastatic non-small cell lung cancer

    phase 1 small molecule active

    1 trial

  6. Characterization of Immune Response in Participants from a Posdinemab Study

    Janssen-Cilag International N.V.

    Early Alzheimer's disease

    phase 1 other active

    1 trial

  7. Chemophase

    HALOZYME THERAPEUTICS, INC.

    Superficial Bladder Cancer

    phase 1 small molecule completed

    1 trial

  8. Chewing Gum

    AXIM BIOTECHNOLOGIES, INC.

    THC

    phase 1 small molecule active

    1 trial

  9. Chimeric antigen receptor T cell

    The First People's Hospital of Lianyungang

    Pancreatic Cancer

    phase 1 small molecule active

    1 trial

  10. Chinese Herbal Compound Ointment

    The First People's Hospital of Lianyungang

    Atrophic Vaginitis

    phase 1 small molecule active

    1 trial

  11. Chinese tea flavor liquor

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Alcohols

    phase 1 other completed

    1 trial

  12. Chlorhexidine

    United Therapeutics Europe Ltd

    Peri-Implantitis

    phase 1 small molecule active

    1 trial

  13. Chloroquine

    GlaxoSmithKline

    Malaria

    phase 1 small molecule completed

    1 trial

  14. Chronocort

    NEUROCRINE BIOSCIENCES INC

    Adrenal Insufficiency

    phase 1 small molecule completed

    2 trials

  15. Ciforadenant

    Corvus Pharmaceuticals

    Renal Cell Cancer

    phase 1 small molecule completed

    1 trial

  16. Ciforadenant

    Corvus Pharmaceuticals

    Multiple Myeloma

    phase 1 small molecule completed

    1 trial

  17. Cigarette

    BRIGHT MINDS BIOSCIENCES INC.

    Cigarette Smoker

    phase 1 small molecule completed

    1 trial

  18. Cilostazol 100 mg tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  19. Cilostazol 50 mg Tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  20. Ciprofloxacin (Cipro InhaIe, BAYQ3939)

    Bayer HealthCare AG

    Pulmonary Disease, Chronic Obstructive

    phase 1 small molecule completed

    1 trial

  21. Ciprofloxacin XR + MMX Placebo

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  22. Cisplatin

    Regeneron UK Limited

    Head and Neck Cancer

    phase 1 small molecule active

    1 trial

  23. Cisplatin

    AstraZeneca

    Inoperable Locally Advanced or Metastatic Biliary Tract Cancer

    phase 1 small molecule terminated

    1 trial

  24. Cisplatin

    BioMarin Pharmaceutical Australia Pty Ltd

    Solid Tumors

    phase 1 small molecule terminated

    1 trial

  25. Cisplatin

    United Therapeutics Europe Ltd

    Advanced Cholangiocarcinoma

    phase 1 small molecule terminated

    1 trial

  26. Citalopram

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Depression

    phase 1 small molecule active

    1 trial

  27. Citarabina Hikma 2 g/20mL Soluzione Iniettabile, Idarubicin Hikma 1 mg/ml Injektionslösung, Cytarabine 100 mg/ml Solution for Injection or Infusion, Cytarabine 100 mg/ml Solution for Injection or Infusion, Daunoblastin® 20 mg Pulver zur Herstellung einer Infusions- oder Injektionslösung, JNJ-75276617, JNJ-75276617 (G022), Venclyxto 100 mg film-coated tablets, Idarubicin, Venclyxto 100 mg film-coated tablets, JNJ-75276617, JNJ-75276617 (G023), Azacitidine, JNJ-75276617, Citarabina Hikma 500mg/5mL Soluzione I

    Janssen-Cilag International N.V.

    Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

  28. Clarithromycin

    BRIGHT MINDS BIOSCIENCES INC.

    Drug-induced QT Prolongation

    phase 1 small molecule completed

    1 trial

  29. Clarithromycin

    Takeda

    Helicobacter Pylori

    phase 1 small molecule completed

    2 trials

  30. Clarithromycin

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  31. Clarithromycin ER 500 mg tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  32. Clascoterone Cream 1%

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Acne Vulgaris

    phase 1 small molecule completed

    1 trial

  33. Clavulanic Acid

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Dependence, in Remission

    phase 1 small molecule completed

    1 trial

  34. Clavulanic acid

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Dependence

    phase 1 small molecule completed

    1 trial

  35. Click-cleavable imaging in HER2-positive cancers (CleavHER trial).

    Disc Medicine

    HER2-positive tumors

    phase 1 other active

    1 trial

  36. Clifutinib

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Healthy Adult Subject

    phase 1 small molecule active

    1 trial

  37. Clifutinib Besylate

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Acute Myeloid Leukemia

    phase 1 small molecule completed

    1 trial

  38. Clifutinib with fed state

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Acute Myeloid Leukemia in Children

    phase 1 small molecule completed

    1 trial

  39. ClinOleic (Baxter Healthcare, Deerfield, IL, USA)

    The First People's Hospital of Lianyungang

    Nutritional Supplement Toxicity

    phase 1 small molecule active

    1 trial

  40. Clindamycin 300 mg capsule

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  41. Clinical Center Reference Endotoxin (CCRE)

    United Therapeutics Europe Ltd

    Healthy

    phase 1 small molecule completed

    1 trial

  42. Clinical research trial for evaluating different properties, such as safety, tolerability and body interaction, of a new drug called ALY688ER, administered as subcutaneous injection in healthy overweight or obese people.

    Lacuna Pharma Pty Ltd

    NASH

    phase 1 other active

    1 trial

  43. Clinical study to evaluate the safety of investigational medicinal product called AD-O51.4 in patients with advanced malignancies

    Lacuna Pharma Pty Ltd

    Patients suffering from cancer without further treatment options.

    phase 1 other active

    1 trial

  44. Clinical trial evaluating the safety, tolerability, and preliminary efficacy of BNT116 alone and in combinations in patients with advanced non-small cell lung cancer

    BioNTech SE

    Advanced non-small cell lung cancer

    phase 1 other active

    1 trial

  45. Clopidogrel

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  46. Coadministration of GA2 Sporozoites With Adjuvants (CoGA)

    Disc Medicine

    Falciparum malaria

    phase 1 other active

    1 trial

  47. Cobimetinib

    Cardiff Oncology

    Locally Advanced Pancreatic Ductal Adenocarcinoma

    phase 1 small molecule active

    1 trial

  48. Cocaine

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Abuse

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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