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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. AVE0005 (aflibercept)

    Regeneron UK Limited

    Colorectal Neoplasms

    phase 1 small molecule completed

    1 trial

  2. AVI-4020 Injection

    Sarepta Therapeutics

    West Nile Fever

    phase 1 small molecule terminated

    1 trial

  3. AVI-4020 Injection

    Sarepta Therapeutics

    West Nile Virus

    phase 1 small molecule completed

    1 trial

  4. AVI-4065 Injection

    Sarepta Therapeutics

    Encephalitis

    phase 1 small molecule completed

    1 trial

  5. AVI-4126 Injection (RESTEN-NG®)

    Sarepta Therapeutics

    Neoplasms

    phase 1 small molecule completed

    1 trial

  6. AVI-6003

    Sarepta Therapeutics

    Marburg Hemorrhagic Fever

    phase 1 small molecule completed

    1 trial

  7. AVI-7100

    Sarepta Therapeutics

    Influenza

    phase 1 small molecule terminated

    1 trial

  8. AVI-7288

    Sarepta Therapeutics

    Marburg Hemorrhagic Fever

    phase 1 small molecule completed

    1 trial

  9. AVI-7537

    Sarepta Therapeutics

    Ebola Hemorrhagic Fever

    phase 1 small molecule terminated

    1 trial

  10. AVICOD 200 MG Film Tablet

    BRIGHT MINDS BIOSCIENCES INC.

    Bioequivalence

    phase 1 small molecule active

    1 trial

  11. AVN-944 capsules for oral administration

    Vertex Pharmaceuticals (Australia) Pty.

    Acute Leukemia

    phase 1 small molecule completed

    1 trial

  12. AZD0449

    AstraZeneca

    Asthma

    phase 1 small molecule completed

    1 trial

  13. AZD0530

    AstraZeneca

    Solid Tumor

    phase 1 small molecule completed

    1 trial

  14. AZD2014 3 on/4 off & weekly paclitaxel

    United Therapeutics Europe Ltd

    Advanced Cancer

    phase 1 small molecule completed

    1 trial

  15. AZD3514

    AstraZeneca

    Prostate Cancer

    phase 1 small molecule completed

    1 trial

  16. AZD5363+Olaparib+Durvalumab

    Hospital Authority, Hong Kong

    Solid Tumor, Adult

    phase 1 small molecule active

    1 trial

  17. AZD5492

    AstraZeneca AB

    B-Cell Malignancies

    phase 1 small molecule active

    1 trial

  18. AZD6244

    AstraZeneca

    Neoplasms,

    phase 1 small molecule completed

    1 trial

  19. AZD7762

    AstraZeneca

    Cancer

    phase 1 small molecule terminated

    1 trial

  20. AZD9150

    IONIS PHARMACEUTICALS INC

    Advanced Adult Hepatocellular Carcinoma

    phase 1 small molecule completed

    1 trial

  21. Abatacept

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Dermatomyositis

    phase 1 small molecule active

    1 trial

  22. Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial Treatment

    Eli Lilly Co.

    Prostatic Neoplasms

    phase 1 other active

    1 trial

  23. Ablation procedure and/or cardioversion

    Rhythm Pharmaceuticals Netherlands B.V.

    Atrial Fibrillation

    phase 1 other completed

    1 trial

  24. Acceptance and Commitment Therapy

    United Therapeutics Europe Ltd

    Stroke

    phase 1 other completed

    1 trial

  25. Aceclidine + Brimonidine

    LENZ Therapeutics

    Eye Diseases

    phase 1 small molecule completed

    1 trial

  26. Acetadote

    CUMBERLAND PHARMACEUTICALS INC

    Glioblastoma

    phase 1 small molecule active

    1 trial

  27. Acetaminophen

    Janssen Cilag International NV

    Healthy

    phase 1 small molecule completed

    1 trial

  28. Acetazolamide

    Ultragenyx UK Limited

    Andersen-Tawil Syndrome

    phase 1 small molecule terminated

    1 trial

  29. Acidform 5 g

    Evofem Biosciences

    Healthy

    phase 1 small molecule completed

    1 trial

  30. Active Cannabis

    BRIGHT MINDS BIOSCIENCES INC.

    Pain

    phase 1 small molecule active

    1 trial

  31. Active Delta-9-THC

    BRIGHT MINDS BIOSCIENCES INC.

    HIV Infections

    phase 1 small molecule completed

    1 trial

  32. Ad-RTS-hIL-12

    Alaunos Therapeutics

    Glioblastoma Multiforme

    phase 1 mab completed

    1 trial

  33. Ad26.COV2.S

    Janssen Cilag International NV

    Healthy

    phase 1 mab completed

    1 trial

  34. Ad5-CB-CFTR

    Ultragenyx UK Limited

    Cystic Fibrosis

    phase 1 gene therapy completed

    1 trial

  35. Ad5-EBOV

    Jian Li

    Ebola Virus Disease

    phase 1 mab completed

    1 trial

  36. AdV-tk

    Candel Therapeutics

    Glioma, Malignant

    phase 1 mab completed

    1 trial

  37. AdV-tk

    Candel Therapeutics

    Malignant Glioma

    phase 1 mab completed

    2 trials

  38. AdV-tk

    Candel Therapeutics

    Pancreatic Adenocarcinoma

    phase 1 mab completed

    1 trial

  39. AdV-tk + valacyclovir

    Candel Therapeutics

    Malignant Pleural Effusion

    phase 1 mab completed

    1 trial

  40. Adapalene

    Teva Pharma GmbH

    Acne Vulgaris

    phase 1 small molecule completed

    1 trial

  41. Adebrelimab

    The First People's Hospital of Lianyungang

    Biliary Tract Malignancies

    phase 1 small molecule active

    1 trial

  42. Adjuvant/Excipients

    Takeda

    Norovirus

    phase 1 small molecule completed

    1 trial

  43. Administration of UI087

    United Therapeutics Europe Ltd

    Diabetes Mellitus (Type 2)

    phase 1 small molecule active

    1 trial

  44. Administration of the malaria inoculum

    CNS Pharmaceuticals

    Malaria

    phase 1 mab completed

    1 trial

  45. Adolescent Methamphetamine Treament (AMT)

    BRIGHT MINDS BIOSCIENCES INC.

    Behavior and Mental Disorders

    phase 1 other completed

    1 trial

  46. Adoptive Cell Therapy with Tumor-infiltrating Lymphocytes (TIL)

    United Therapeutics Europe Ltd

    Urothelial Carcinoma

    phase 1 mab active

    1 trial

  47. Adoptive Cell Transfer of NKG2DL-targetting Chimeric Antigen Receptor-grafted Gamma Delta T cell

    CytoMed Therapeutics Ltd

    Colorectal Cancer

    phase 1 mab active

    1 trial

  48. Adoptive TIL therapy in combination with chemoimmunotherapy in advanced NSCLC patients

    Disc Medicine

    Respiratory tract diseases

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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