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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 17 of 99

  1. AG-181

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  2. AG-181

    Agios Netherlands B.V.

    Phenylketonuria

    phase 1 small molecule active

    1 trial

  3. AG-236

    Agios Netherlands B.V.

    Healthy Participants

    phase 1 small molecule active

    1 trial

  4. AG-348

    Agios Netherlands B.V.

    Healthy Volunteer

    phase 1 small molecule completed

    2 trials

  5. AG-348

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  6. AG-348

    Agios Netherlands B.V.

    Healthy

    phase 1 small molecule completed

    1 trial

  7. AG-348

    Agios Netherlands B.V.

    Sickle Cell Disease

    phase 1 small molecule completed

    1 trial

  8. AG-348 Sequence A

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  9. AG-519

    Agios Netherlands B.V.

    Anemia

    phase 1 small molecule terminated

    1 trial

  10. AG-636

    Agios Netherlands B.V.

    Lymphoma

    phase 1 small molecule terminated

    1 trial

  11. AG-881

    Agios Netherlands B.V.

    Healthy Male Participants

    phase 1 small molecule completed

    1 trial

  12. AG-881

    Agios Netherlands B.V.

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  13. AG-946

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  14. AG10 oral tablet

    BridgeBio Oncology Therapeutics

    Amyloid Cardiomyopathy, Transthyretin-Related

    phase 1 small molecule completed

    1 trial

  15. AG120

    Agios Netherlands B.V.

    Healthy

    phase 1 small molecule completed

    2 trials

  16. AG221

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  17. AG881

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  18. AG881

    Agios Netherlands B.V.

    Acute Myeloid Leukemia (AML)

    phase 1 small molecule completed

    1 trial

  19. AG881 Formulation 1

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  20. AGMB-129

    Agomab Therapeutics NV

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  21. AGMB-447

    Agomab Therapeutics NV

    IPF

    phase 1 small molecule active

    1 trial

  22. AIR DNase

    Protalix BioTherapeutics

    Cystic Fibrosis (CF)

    phase 1 small molecule completed

    1 trial

  23. AK120 or placebo- Part 1- Cohort 1

    Akeso

    Atopic Dermatitis

    phase 1 small molecule completed

    1 trial

  24. AKB-6548

    Akebia Europe Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  25. AKB-6548 (therapeutic dose)

    Akebia Europe Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  26. AKB-6548 tablet, reference formulation given in the fasted state

    Akebia Europe Limited

    Healthy

    phase 1 small molecule completed

    1 trial

  27. AKB-9090

    Akebia Europe Limited

    Healthy Volunteers

    phase 1 small molecule active

    1 trial

  28. ALG-000184

    Aligos Therapeutics

    Chronic Hepatitis B

    phase 1 small molecule completed

    1 trial

  29. ALG-010133

    Aligos Therapeutics

    Chronic Hepatitis B

    phase 1 small molecule terminated

    1 trial

  30. ALG-020572

    Aligos Therapeutics

    Chronic Hepatitis B

    phase 1 small molecule terminated

    1 trial

  31. ALG-055009

    Aligos Therapeutics

    Healthy Volunteer Study

    phase 1 small molecule completed

    1 trial

  32. ALG-055009

    Aligos Therapeutics

    NASH - Nonalcoholic Steatohepatitis

    phase 1 small molecule completed

    1 trial

  33. ALG-097558

    Aligos Therapeutics

    COVID-19

    phase 1 small molecule completed

    3 trials

  34. ALG-125755

    Aligos Therapeutics

    Chronic Hepatitis B

    phase 1 small molecule terminated

    1 trial

  35. ALKS 33-BUP

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Abuse

    phase 1 small molecule completed

    1 trial

  36. ALLO-316

    Allogene Therapeutics

    Advanced/Metastatic Clear Cell Renal Cell Carcinoma

    phase 1 gene therapy active

    1 trial

  37. ALLO-329

    Allogene Therapeutics

    Systemic Lupus Erythematosus (With and Without Nephritis)

    phase 1 gene therapy active

    1 trial

  38. ALLO-501

    Allogene Therapeutics

    Relapsed/Refractory Large B Cell Lymphoma

    phase 1 gene therapy completed

    1 trial

  39. ALLO-715

    Allogene Therapeutics

    Relapsed/Refractory Multiple Myeloma

    phase 1 gene therapy completed

    1 trial

  40. ALN-4285

    Alnylam Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule active

    1 trial

  41. ALN-4915

    Alnylam Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule active

    1 trial

  42. ALN-5288

    Alnylam Netherlands B.V.

    Alzheimer's Disease

    phase 1 small molecule active

    1 trial

  43. ALN-AAT

    Alnylam Netherlands B.V.

    Antitrypsin Deficiency Liver Disease

    phase 1 small molecule terminated

    1 trial

  44. ALN-AGT01

    Alnylam Netherlands B.V.

    Hypertension

    phase 1 small molecule completed

    1 trial

  45. ALN-AGT01 RVR

    Alnylam Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  46. ALN-ANG3

    Regeneron UK Limited

    Healthy Volunteers With Hyperlipidemia

    phase 1 small molecule active

    1 trial

  47. ALN-APOC3

    Regeneron UK Limited

    Dyslipidemia

    phase 1 small molecule completed

    1 trial

  48. ALN-APP

    Alnylam Netherlands B.V.

    Early-Onset Alzheimer Disease

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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