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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

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NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

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  1. An open-label, single-dose, parallel-group study to evaluate the plasma pharmacokinetics of leniolisib in subjects with impaired hepatic function and in subjects with normal hepatic function

    Pharming Technologies B.V.

    Activated Phosphoinositide 3-Kinase Delta Syndrome

    phase 1 other active

    1 trial

  2. Anagrelide 0.5 mg

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  3. Anastrozole

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  4. Anastrozole (Teva Pharmaceuticals USA)

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  5. Anlotinib hydrochloride,Penpulimab

    The First People's Hospital of Lianyungang

    Colorectal Cancer

    phase 1 small molecule active

    1 trial

  6. Anplag

    United Therapeutics Europe Ltd

    Healthy

    phase 1 small molecule completed

    1 trial

  7. Anti CS6 BSIgG product (Lot PD1601105CS)

    United Therapeutics Europe Ltd

    Healthy Volunteer

    phase 1 mab completed

    1 trial

  8. Anti-BCMA CAR-T cells

    The First People's Hospital of Lianyungang

    Multiple Myeloma

    phase 1 mab active

    1 trial

  9. Anti-CD123 CAR NK cells

    Chongqing Precision Biotech Co., Ltd

    AML (Acute Myeloid Leukemia)

    phase 1 small molecule active

    1 trial

  10. Anti-CD19 UCAR-T cells

    Chongqing Precision Biotech Co., Ltd

    Dermatomyositis, Juvenile

    phase 1 small molecule active

    1 trial

  11. Anti-CD19 Universal CAR-T Cells injection

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia

    phase 1 mab active

    1 trial

  12. Anti-CD19-CAR

    The First People's Hospital of Lianyungang

    Leukemia

    phase 1 mab active

    1 trial

  13. Anti-CD20 monoclonal antibody and the BTK inhibitor

    The First People's Hospital of Lianyungang

    Anti-CD20 Monoclonal Antibody

    phase 1 small molecule active

    1 trial

  14. Anti-CD30 CAR T cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Adult T-Cell Lymphoma/Leukaemia

    phase 1 gene therapy active

    1 trial

  15. Anti-CD5 CAR NK cells

    Chongqing Precision Biotech Co., Ltd

    T-ALL/Lymphoma

    phase 1 mab active

    1 trial

  16. Anti-CDH17 CAR-T cells infusion

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    CDH17-positive Advanced Solid Tumors

    phase 1 mab active

    1 trial

  17. Anti-CLL1 CART cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

  18. Anti-GD2 ADC M3554 in Advanced Solid Tumors

    Merck Sharp and Dohme

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  19. Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

    Merck Sharp and Dohme

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  20. Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody

    Takeda

    Metastatic Adenocarcinoma of the Colon or Rectum

    phase 1 mab completed

    1 trial

  21. Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody

    Takeda

    Systemic Lupus Erythematosus

    phase 1 small molecule terminated

    1 trial

  22. Anti-SEMA4D Monoclonal Antibody VX15/2503

    VACCINEX, INC.

    Metastatic Melanoma

    phase 1 mab terminated

    1 trial

  23. Anti-SEMA4D Monoclonal Antibody VX15/2503

    VACCINEX, INC.

    Colon Carcinoma Metastatic in the Liver

    phase 1 mab completed

    1 trial

  24. Anti-human CCL24 monoclonal antibody (CM-101)

    Chemomab Therapeutics

    Healthy

    phase 1 small molecule completed

    1 trial

  25. Anti-human CCL24 monoclonal antibody (CM-101) - Part One

    Chemomab Therapeutics

    Nonalcoholic Fatty Liver Disease

    phase 1 small molecule completed

    1 trial

  26. Antibody UB-421

    United Therapeutics Europe Ltd

    HIV-1 Infection in Adults (Asymptomatic)

    phase 1 small molecule completed

    1 trial

  27. Aramchol

    Galmed Pharmaceuticals

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  28. Aramchol

    Galmed Pharmaceuticals

    NASH

    phase 1 small molecule completed

    1 trial

  29. Aramchol

    Galmed Pharmaceuticals

    Healthy

    phase 1 small molecule active

    4 trials

  30. Aramchol free acid tablet 600mg, single dose

    Galmed Pharmaceuticals

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  31. Aramchol meglumine

    Galmed Pharmaceuticals

    Healthy

    phase 1 small molecule active

    1 trial

  32. Arbaclofen Placarbil SR

    Indivior Pty Ltd

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  33. Aricept 5mg Tablet

    Dong Wang

    Healthy

    phase 1 small molecule active

    1 trial

  34. Aripiprazole

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine-Related Disorders

    phase 1 small molecule completed

    1 trial

  35. Arm 1 cemiplimab

    Regeneron UK Limited

    Hepatocellular Carcinoma

    phase 1 small molecule active

    1 trial

  36. Arm 1: IL13Ra2-specific CAR Tcm cells

    BRIGHT MINDS BIOSCIENCES INC.

    Recurrent Glioblastoma

    phase 1 mab active

    1 trial

  37. Arm B: A combination of pentoxifylline and tocopherol acetate in addition to best standard care [a structured programme of rehabilitation exercises] for 6 months

    United Therapeutics Europe Ltd

    Head and Neck Fibrosis

    phase 1 other completed

    1 trial

  38. Arsenic trioxide

    Teva Pharma GmbH

    Chronic Myelogenous Leukemia

    phase 1 small molecule terminated

    1 trial

  39. Artesunate (Test)

    Pfizer

    Falciparum Malaria

    phase 1 small molecule completed

    1 trial

  40. Aspirin

    Regeneron UK Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  41. Aspirin

    Protalix BioTherapeutics

    Bioequivalence

    phase 1 small molecule completed

    1 trial

  42. Assessment of Pharmacokinetic Similarity of FYB206 in Comparison with Keytruda in Resected Stage II or Stage III Melanoma Patients

    Formycon AG

    Melanoma: Adjuvant treatment of patients with Stage IIB, IIC, or III melanoma following complete resection

    phase 1 other active

    1 trial

  43. Assessment of narrowing of blood vessels after single application of two clascoterone formulations (cream and solution) onto the skin in comparison to three marketed topical corticosteroids

    Cassiopea S.p.A.

    Test of vasocontriction properties for classification of topical steroid potency

    phase 1 other active

    1 trial

  44. Asundexian Bayer 10mg Granules, BAY 2433334

    Bayer AG

    Prevention of thromboembolic events

    phase 1 small molecule active

    1 trial

  45. Ataluren

    PTC THERAPEUTICS, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  46. Atezolizumab

    Hoffmann-La Roche

    Advanced Ovarian Cancer

    phase 1 small molecule terminated

    1 trial

  47. Atezolizumab

    Jazz Pharmaceuticals Ireland Limited

    Endometrial Cancer

    phase 1 small molecule active

    1 trial

  48. Atorvastatin

    Lakefront Biotherapeutics NV

    Rheumatoid Arthritis

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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