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Intelligence Β· Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 21 of 99

  1. Aflibercept

    Regeneron UK Limited

    Neovascular Macular Degeneration

    phase 1 small molecule completed

    1 trial

  2. Aflibercept

    Regeneron UK Limited

    Irvine-Gass Syndrome

    phase 1 small molecule terminated

    1 trial

  3. Aflibercept (AVE0005)

    Regeneron UK Limited

    Neoplasm Malignant

    phase 1 small molecule completed

    2 trials

  4. Aflibercept every 2 months

    Regeneron UK Limited

    Radiation Retinopathy

    phase 1 small molecule completed

    1 trial

  5. Airway Bypass

    CATALYST PHARMACEUTICALS, INC.

    Emphysema or COPD

    phase 1 other active

    1 trial

  6. Akk Gut Bacteria Supplement

    The First People's Hospital of Lianyungang

    Premature Ovarian Failure (POF)

    phase 1 other active

    1 trial

  7. Albuterol dry powder inhaler

    Teva Pharma GmbH

    Asthma

    phase 1 small molecule completed

    1 trial

  8. Alcohol

    BRIGHT MINDS BIOSCIENCES INC.

    Alcohol Drinking

    phase 1 small molecule completed

    1 trial

  9. Alcohol

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Use

    phase 1 small molecule completed

    1 trial

  10. Alcohol + Caffeine Beverage

    BRIGHT MINDS BIOSCIENCES INC.

    Alcohol or Other Drugs Effects

    phase 1 small molecule completed

    1 trial

  11. Alendronate Sodium Tablets 70mg

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  12. Alirocumab

    Regeneron UK Limited

    Stroke

    phase 1 small molecule terminated

    1 trial

  13. Alirocumab

    Regeneron UK Limited

    Sepsis

    phase 1 small molecule completed

    1 trial

  14. Alirocumab (Solution)

    Regeneron UK Limited

    Hypercholesterolemia

    phase 1 small molecule completed

    1 trial

  15. Alisertib

    Takeda

    Advanced Solid Tumors

    phase 1 small molecule completed

    7 trials

  16. Alisertib

    Takeda

    B-cell Follicular Lymphoma

    phase 1 small molecule completed

    1 trial

  17. Alisertib

    Takeda

    Solid Tumors

    phase 1 small molecule completed

    1 trial

  18. All-trans retinoic acid

    The First People's Hospital of Lianyungang

    Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

  19. Allo-depleted lymphocyte infusion

    Lxo Ireland Designated Activity Company

    Transplant-Related Hematologic Malignancy

    phase 1 other terminated

    1 trial

  20. Allogeneic (MSC's) Application to the Burn Wounds

    United Therapeutics Europe Ltd

    Skin Burn Degree Second

    phase 1 mab completed

    1 trial

  21. Allogeneic CD19/BCMA-targeted CAR-Ξ³Ξ΄T cell injection

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Refractory/Relapsed Systemic Lupus Erythematosus

    phase 1 mab active

    1 trial

  22. Allogeneic Cardiosphere-Derived Cells (CDCs)

    CAPRICOR THERAPEUTICS, INC.

    Dilated Cardiomyopathy (DCM)

    phase 1 mab active

    1 trial

  23. Allogeneic MSC

    United Therapeutics Europe Ltd

    Mesenchymal Stromal Cells

    phase 1 mab completed

    1 trial

  24. Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted Ξ³Ξ΄ T Cells (CTM-N2D)

    CytoMed Therapeutics Ltd

    Cancer

    phase 1 mab active

    1 trial

  25. Allogeneic anti-CD7 CAR-T cells (BEAM-201)

    Beam Therapeutics

    T-Cell Acute Lymphoblastic Leukemia/Lymphoma

    phase 1 mab active

    1 trial

  26. Alogliptin

    Takeda

    Pharmacokinetics and Pharmacodynamics

    phase 1 small molecule completed

    1 trial

  27. Alogliptin

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  28. Alprazolam Extended-Release 3 mg Tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  29. AmBisome liposomale amfotericine B 50 mg, poeder voor oplossing voor infusie, TECHNETIUM (99MTC) PERTECHNETATE

    Disc Medicine

    Chronic pulmonary aspergillosis

    phase 1 small molecule active

    1 trial

  30. Amitriptyline Hydrochloride 25Mg Tablet（Hunan DongtingοΌ‰

    The First People's Hospital of Lianyungang

    Depressive Disorder

    phase 1 small molecule completed

    1 trial

  31. Amlodipine Besylate

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  32. Amlodipine-benazepril 10 mg-20 mg capsules

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  33. Amoxicillin + MMX placebo

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  34. Amphetamine

    NEUROCRINE BIOSCIENCES INC

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  35. Ampreloxetine

    Theravance Biopharma Ireland Umited

    Symptomatic Neurogenic Orthostatic Hypertension

    phase 1 small molecule completed

    1 trial

  36. Ampreloxetine <Dose A>

    Theravance Biopharma Ireland Umited

    Symptomatic Neurogenic Orthostatic Hypertension

    phase 1 small molecule completed

    1 trial

  37. An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab

    AstraZeneca AB

    Inflammation, Respiratory

    phase 1 other active

    1 trial

  38. An Early Phase Study to Investigate the Safety and Efficacy of HS135 in Adult Patients With Pulmonary Arterial Hypertension (PAH)

    Lacuna Pharma Pty Ltd

    Pulmonary arterial hypertension

    phase 1 other active

    1 trial

  39. An Early-Stage Study in Multiple Clinics of how Afimkibart May Affect the Body’s Processing of Medicines that Rely on Cytochrome P450 Enzymes in Patients with Ulcerative Colitis

    Hoffmann-La Roche

    Active Ulcerative Colitis (UC)

    phase 1 other active

    1 trial

  40. An Open Label Study to Assess the Effect of Patient Use and Robustness on Tiotropium Bromide Spray 2.5ΞΌg, Soft Mist Inhaler device

    Laboratorios Tillomed Spain S.L.U

    Chronic obstructive pulmonary disease

    phase 1 other active

    1 trial

  41. An Open Label, Phase 1, Treatment Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of IDE397 (MAT2A Inhibitor) In Adult Participants with Advanced Solid Tumors.

    IDEAYA Biosciences

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  42. An Open-Label Multicenter Phase 1b Study of Tolinapant (ASTX660) in Combination With Radiotherapy/Chemoradiotherapy (RT/CRT) in Preoperative Treatment of Patients With Rectum Cancer (PRAAR 1: Preoperative Radiotherapy And ASTX660 in Rectum Cancer)

    The George Institute

    Neoadjuvant therapy in locally-advanced rectal cancer

    phase 1 other active

    1 trial

  43. An Open-Label Trial to Assess the Comparative Bioavailability of TV-44749 to Oral Olanzapine in Participants with Schizophrenia

    Lacuna Pharma Pty Ltd

    Schizophrenia

    phase 1 other active

    1 trial

  44. An Open-Label, Phase 1 Study of the CTPS1 Inhibitor STP938 in Adult Subjects with Advanced Solid Tumors, with a Safety Expansion in Advanced CTPS2 Null Ovarian Cancer

    Lacuna Pharma Pty Ltd

    Solid tumors and ovarian cancer

    phase 1 other active

    1 trial

  45. An Open-Label, Phase 1b Study to Evaluate Safety, Tolerability and Preliminary Activity of the CTPS1 Inhibitor STP938 in Adult Subjects with High Risk Essential Thrombocythaemia who are Resistant to or Intolerant of Hydroxycarbamide Therapy. The VECTRA Study

    Lacuna Pharma Pty Ltd

    Thrombocythaemia

    phase 1 other active

    1 trial

  46. An Open-Label, Rollover Platform Study for Continued Study Treatment and Ongoing Safety Monitoring

    Janssen-Cilag International N.V.

    Non-Hodgkin lymphoma and chronic lymphocytic leukemia

    phase 1 other active

    1 trial

  47. An Open-label, Single-dose Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of JNJ-77242113 in Adult Participants

    Janssen-Cilag International N.V.

    Renal Impairment

    phase 1 other active

    1 trial

  48. An Open-label, Single-group, Three-period, Fixed-sequence, Phase I Study to Assess the Pharmacokinetics of AZD6793 Tablets When Administered Alone and in Combination with Itraconazole Capsules in Healthy Adult Female and Male Participants

    AstraZeneca AB

    Chronic obstructive pulmonary disease

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources Β· All pipeline programs

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