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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. Tiragolumab, CISPLATIN , Tecentriq 1 200 mg concentrate for solution for infusion, GEMCITABINE

    Hoffmann-La Roche

    Urothelial carcinoma (UC)

    phase 1 small molecule active

    1 trial

  2. Tirzepatide

    Eli Lilly and Company

    Healthy

    phase 1 small molecule completed

    1 trial

  3. Tissue Plasminogen Activator (tPA)

    Hospital Authority, Hong Kong

    Peritoneal Dialysis

    phase 1 small molecule terminated

    1 trial

  4. To assess the relative BA of a low-strength FDC tablet formulation of niraparib plus AA compared to niraparib and AA co-administered as single agents after single dose administration and to assess BE of a regular strength FDC tablet formulation of niraparib plus AA compared to niraparib and AA co-administered as single agents at steady state in men with prostate cancer

    Janssen-Cilag International N.V.

    Metastatic castration-resistant prostate cancer (mCRPC)

    phase 1 other active

    1 trial

  5. To evaluate the pharmacokinetics and safety of nolasiban

    Novo Nordisk A/S

    not applicable (submitted trial is a pharmacokinetic study in healthy subjects)

    phase 1 other active

    1 trial

  6. Tofacitinib tablets

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Amyotrophic Lateral Sclerosis

    phase 1 small molecule active

    1 trial

  7. Tolvaptan 15mg or 30mg or 60mg or Placebo

    Otsuka Beijing Research Institute

    Healthy

    phase 1 small molecule completed

    1 trial

  8. Topiramate 2 x 25 mg tablet

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  9. Topiramate 25 mg Capsules

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  10. Topiramate Capsules, 25 mg

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  11. Topiramate IR

    SUPERNUS PHARMACEUTICALS, INC.

    Epilepsy

    phase 1 small molecule completed

    1 trial

  12. Topiramate Tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  13. Training with 4D Motion Capture Device

    4D Molecular Therapeutics

    Stroke

    phase 1 other completed

    1 trial

  14. Trandolapril 4 mg Tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  15. Tranexamic Acid；

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Iatrogenic Endobronchial Bleeding

    phase 1 small molecule active

    1 trial

  16. Tranilast

    The First People's Hospital of Lianyungang

    Mucinoses

    phase 1 small molecule active

    1 trial

  17. TransCon PEG treprostinil

    United Therapeutics Europe Ltd

    PAH

    phase 1 small molecule terminated

    1 trial

  18. Transdermal Nicotine Patch

    BRIGHT MINDS BIOSCIENCES INC.

    E-cigarette Use

    phase 1 small molecule active

    1 trial

  19. Trastuzumab

    Hoffmann-La Roche

    Early Breast Cancer

    phase 1 small molecule completed

    1 trial

  20. Trastuzumab Deruxtecan

    Daiichi Sankyo

    Recurrent or Metastatic Solid Tumors

    phase 1 small molecule active

    1 trial

  21. Trastuzumab Deruxtecan, and pembrolizumab in participants with Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer

    Daiichi Sankyo

    Locally advanced/metastatic breast or non-small cell lung cancer

    phase 1 other active

    1 trial

  22. Treatment A

    Tonix Pharmaceuticals Holding

    Healthy Adults

    phase 1 small molecule completed

    1 trial

  23. Treatment A

    Pfizer

    Asthma

    phase 1 small molecule completed

    1 trial

  24. Treatment A

    Pfizer

    Healthy

    phase 1 small molecule completed

    1 trial

  25. Treatment A

    Tonix Pharmaceuticals Holding

    Healthy

    phase 1 small molecule completed

    1 trial

  26. Treatment A (rosuvastatin)

    LEXICON PHARMACEUTICALS, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  27. Treatment A digoxin

    LEXICON PHARMACEUTICALS, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  28. Treatment A-Bemnifosbuvir/Ruzasvir FDC administered fasting

    Atea Pharmaceuticals

    Healthy Volunteer Study

    phase 1 small molecule completed

    1 trial

  29. Treatment A: Fp MDPI

    Teva Pharma GmbH

    Asthma

    phase 1 small molecule completed

    1 trial

  30. Treatment as usual (TAU)

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Abuse

    phase 1 other completed

    1 trial

  31. Treatment of Respiratory Complications Associated with COVID-19, Influenza A, Metapneumovirus, Respiratory Syncytial Virus (RSV) Infection Using Wharton’s Jelly (WJ)-Umbilical Cord (UC) Mesenchymal Stromal Cells (ProTrans®): open Phase IB Clinical Trial

    Lacuna Pharma Pty Ltd

    Respiratory viral disease, COVID-19, Influenza A, Metapneumovirus, Respiratory syncytial virus Infection

    phase 1 other active

    1 trial

  32. Treatment of advanced or metastatic triple negative breast cancer with tumor infiltrating lymphocytes (TILs).

    The George Institute

    advanced or metastasic triple-negative breast cancer

    phase 1 other active

    1 trial

  33. Treatment of cancer with Immune Checkpoint Inhibition therapy boosted by High Intensity Focused Ultrasound Histotripsy (the iFOCUS study)

    Disc Medicine

    Metastatic or unresectable solid malignancies. Standard of care treatment options must not be available or not be considered feasible. Patients must have a primary tumor or metastasis that is suitable for HIFU-HT treatment.

    phase 1 other active

    1 trial

  34. Treatment sequence AB

    Vertex Pharmaceuticals (Australia) Pty.

    Hepatitis C

    phase 1 small molecule completed

    1 trial

  35. Trebananib 3 mg/kg

    Takeda

    Neoplasms, Advanced Solid

    phase 1 small molecule completed

    1 trial

  36. Treprostinil Inhalation Powder

    United Therapeutics Europe Ltd

    Pulmonary Arterial Hypertension

    phase 1 small molecule completed

    1 trial

  37. Treprostinil diethanolamine

    United Therapeutics Europe Ltd

    Hypertension, Pulmonary

    phase 1 small molecule completed

    2 trials

  38. Trial of the novel peroral anti-tumor treatment in patients with solid tumors

    Lacuna Pharma Pty Ltd

    Metastatic or locally advanced solid tumors for which no standard therapy exists or standard therapy has failed: tumors of lung, head and neck, colon, stomach, esophagus, breast, ovary and/or fallopian tube or primary peritoneal high-grade serous carcinoma

    phase 1 other active

    1 trial

  39. Trial to Evaluate the Safety and Preliminary Efficacy of GEN1079 in Participants with Advanced Solid Tumors

    Genmab A/S

    Advanced Malignant Solid Tumors

    phase 1 other active

    1 trial

  40. Trial to assess the safety and antitumor activity of GEN1057 on malignant solid tumors

    Genmab A/S

    Metastatic or advanced malignant solid tumors

    phase 1 other active

    1 trial

  41. Trial to evaluate the administration of IDOR-1134-2831 vaccine in healthy participants

    Lacuna Pharma Pty Ltd

    Clostridioides difficile (C. difficile)

    phase 1 other active

    1 trial

  42. Triamcinolone Acetonide Extended-Release Injectable Suspension

    Pacira Ireland Limited

    Osteoarthritis, Knee

    phase 1 small molecule completed

    1 trial

  43. Trichostatin A

    Vanda Pharmaceuticals Netherlands B.V.

    Relapsed or Refractory Hematologic Malignancies

    phase 1 small molecule active

    1 trial

  44. Triheptanoin

    Ultragenyx UK Limited

    Pyruvate Dehydrogenase Complex Deficiency

    phase 1 small molecule active

    1 trial

  45. Triheptanoin

    Ultragenyx UK Limited

    Glycogen Storage Disease Type I

    phase 1 small molecule completed

    1 trial

  46. Triprorelin for injection

    The First People's Hospital of Lianyungang

    Prostate Cancer (CRPC)

    phase 1 small molecule active

    1 trial

  47. Tuberculosis (TB) vaccine (Ad5-105K)

    CanSino Biologics

    Tuberculosis

    phase 1 mab active

    1 trial

  48. Tuberculosis Vaccine

    Biotech Pharmaceutical Co.,

    Tuberculosis

    phase 1 mab completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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