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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. Tuvusertib (M1774) Human Mass Balance and Absolute Bioavailability Study (DDRIVER Solid Tumors 303)

    Merck Sharp and Dohme

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  2. Tuvusertib (M1774) in Participants with Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

    Merck Sharp and Dohme

    Metastatic or Locally Advanced Unresectable Solid Tumors

    phase 1 other active

    1 trial

  3. Two doses of middle-dose recombinant SARS-CoV-2 vaccine (Sf9 Cell) at the schedule of day 0, 28

    Jiangsu Province Centers for Disease Control and Prevention

    COVID-19

    phase 1 mab completed

    1 trial

  4. U96

    The First People's Hospital of Lianyungang

    Relapsed or Refractory B Cell Leukemia and Lymphoma

    phase 1 small molecule active

    1 trial

  5. UB-221

    United Therapeutics Europe Ltd

    Chronic Idiopathic Urticaria

    phase 1 small molecule active

    1 trial

  6. UB-221

    United Therapeutics Europe Ltd

    Urticaria Chronic

    phase 1 mab completed

    1 trial

  7. UB-221

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Chronic Spontaneous Urticaria

    phase 1 mab active

    1 trial

  8. UB-312

    BRIGHT MINDS BIOSCIENCES INC.

    Parkinson's Disease

    phase 1 mab completed

    1 trial

  9. UB-421 SC

    United Therapeutics Europe Ltd

    HIV-1-infection

    phase 1 mab active

    1 trial

  10. UB-421 SC(dB4C7C22-6 mAb)

    United Therapeutics Europe Ltd

    HIV-1 Infection

    phase 1 mab completed

    1 trial

  11. UB-621

    United Therapeutics Europe Ltd

    Herpes Simplex Virus Infection

    phase 1 small molecule completed

    1 trial

  12. UB-921

    United Therapeutics Europe Ltd

    Breast Neoplasm

    phase 1 mab completed

    1 trial

  13. UB-VV410

    The First People's Hospital of Lianyungang

    Systemic Lupus Erythematosus

    phase 1 small molecule active

    1 trial

  14. UCBMC

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Stroke

    phase 1 mab active

    1 trial

  15. UCMSC

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Bronchopleural Fistula

    phase 1 mab active

    1 trial

  16. UI009

    United Therapeutics Europe Ltd

    Health

    phase 1 small molecule completed

    1 trial

  17. UI059

    United Therapeutics Europe Ltd

    GERD

    phase 1 small molecule completed

    1 trial

  18. UI059

    United Therapeutics Europe Ltd

    Gastro-Intestinal Disorder

    phase 1 small molecule active

    1 trial

  19. UI15AML055MT

    United Therapeutics Europe Ltd

    Healthy

    phase 1 small molecule completed

    1 trial

  20. UIC201602 and co-administration of UIC201601 and UIC201602

    United Therapeutics Europe Ltd

    Healthy

    phase 1 small molecule completed

    1 trial

  21. UKidney

    United Therapeutics Europe Ltd

    Kidney Failure, Chronic

    phase 1 other terminated

    1 trial

  22. UNEX-42

    United Therapeutics Europe Ltd

    Bronchopulmonary Dysplasia

    phase 1 mab terminated

    1 trial

  23. UP421

    Sana Biotechnology

    Type1diabetes

    phase 1 mab active

    1 trial

  24. USB005 (aclerastide) Ophthalmic Solution

    United Therapeutics Europe Ltd

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  25. UT-15C

    United Therapeutics Europe Ltd

    Healthy

    phase 1 small molecule completed

    2 trials

  26. UT-15C SR (treprostinil diethanolamine)

    United Therapeutics Europe Ltd

    Pulmonary Arterial Hypertension

    phase 1 small molecule completed

    1 trial

  27. UTAA09 injection

    The First People's Hospital of Lianyungang

    Recurrent or Refractory B-cell Non Hodgkin's Lymphoma

    phase 1 mab active

    1 trial

  28. UTAA91 injection

    Suzhou Ribo Life Science Co.

    Rheumatoid Arthritis (RA)

    phase 1 mab active

    1 trial

  29. UTAA91 injection

    Hospital Authority, Hong Kong

    Rheumatoid Arthritis (RA)

    phase 1 mab active

    1 trial

  30. UX-GIP001

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Epilepsy

    phase 1 small molecule active

    1 trial

  31. Ublituximab + TGR-1202

    TG THERAPEUTICS, INC.

    Chronic Lymphocytic Leukemia

    phase 1 small molecule completed

    1 trial

  32. Understanding the effect of CagriSema, cagrilintide, and semaglutide on muscle health

    NovoThirteen

    Obesity, CCI, CCI

    phase 1 other active

    1 trial

  33. Unesbulin

    PTC THERAPEUTICS, INC.

    Ovarian Cancer

    phase 1 small molecule completed

    1 trial

  34. Ursodiol

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  35. V920

    United Therapeutics Europe Ltd

    Ebola Virus

    phase 1 mab completed

    1 trial

  36. V930

    INOVIO PHARMACEUTICALS, INC.

    Healthy

    phase 1 mab completed

    1 trial

  37. VCH 916

    Vertex Pharmaceuticals (Australia) Pty.

    HCV Infection

    phase 1 small molecule completed

    1 trial

  38. VCH-222

    Vertex Pharmaceuticals (Australia) Pty.

    Hepatitis C

    phase 1 small molecule completed

    1 trial

  39. VCTX210A unit

    S.A.

    Diabetes Mellitus

    phase 1 other completed

    1 trial

  40. VCTX211

    S.A.

    Diabetes Mellitus

    phase 1 other terminated

    1 trial

  41. VEGF Trap

    Regeneron UK Limited

    Macular Degeneration

    phase 1 small molecule completed

    1 trial

  42. VEGF Trap

    Regeneron UK Limited

    Neovascular Age Related Macular Degeneration

    phase 1 small molecule completed

    1 trial

  43. VEGF Trap-Eye

    Regeneron UK Limited

    Diabetic Macular Edema

    phase 1 small molecule completed

    1 trial

  44. VEGF inhibitor PTC299

    PTC THERAPEUTICS, INC.

    Brain and Central Nervous System Tumors

    phase 1 small molecule completed

    1 trial

  45. VGB-R04

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Hemophilia B

    phase 1 gene therapy active

    1 trial

  46. VGX-3100

    INOVIO PHARMACEUTICALS, INC.

    Human Papillomavirus (HPV)

    phase 1 mab completed

    1 trial

  47. VGX-3100

    INOVIO PHARMACEUTICALS, INC.

    Papillomavirus Infections

    phase 1 mab completed

    1 trial

  48. VGX-3400

    INOVIO PHARMACEUTICALS, INC.

    Healthy

    phase 1 mab completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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