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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. Vadadustat

    Akebia Europe Limited

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  2. Vadadustat

    Akebia Europe Limited

    Drug Interaction Potentiation

    phase 1 small molecule completed

    4 trials

  3. Vadadustat

    Akebia Europe Limited

    Anemia Associated With Chronic Kidney Disease

    phase 1 small molecule completed

    1 trial

  4. Vagal Nerve Stimulation

    Rhythm Pharmaceuticals Netherlands B.V.

    Inflammation

    phase 1 other completed

    1 trial

  5. Vagus Nerve Stimulation

    Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd

    Refractory Epilepsy

    phase 1 other active

    1 trial

  6. Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg

    Hospital Authority, Hong Kong

    COVID-19 Pandemic

    phase 1 mab active

    1 trial

  7. Valacyclovir

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  8. Valemetostat Tosylate, DS-8201a, Datopotamab deruxtecan, Valemetostat Tosylate, Valemetostat Tosylate

    Daiichi Sankyo

    This study will be a Phase 1b, global, multicenter, open-label, 2-part study of valemetostat in combination with DXd ADCs. The Master Protocol study design contains independent subprotocols, which have been defined by treatment combination and subject population, as follows: Sub-protocol A: Valemetostat in combination with T-DXd in subjects with previously treated, unresectable and/or metastatic HER2-low (immunohistochemistry[IHC] 1+ or IHC 2+/in situ hybridization [ISH]-negative) BC; for details, see Sub-protocol A. Sub-protocol B: Valemetostat in combination with T-DXd in subjects with previously treated, advanced or metastatic HER2-positive gastric or GEJ adenocarcinoma; for details, see Sub-protocol B. Sub-protocol C: Valemetostat in combination with Dato-DXd in subjects with previously treated, locally advanced, unresectable, or metastatic non-squamous NSCLC with or without actionable genomic alteration(s); for details, see Sub-protocol C.

    phase 1 small molecule active

    1 trial

  9. Vancomycin Pre-Treatment

    Seres Therapeutics

    Allogeneic Hematopoietic Stem Cell Transplantation

    phase 1 small molecule completed

    1 trial

  10. Vantictumab

    Mereo BioPharma Group plc

    Pancreatic Cancer

    phase 1 small molecule completed

    1 trial

  11. Vantictumab combined with paclitaxel

    Mereo BioPharma Group plc

    Metastatic Breast Cancer

    phase 1 small molecule completed

    1 trial

  12. Vanzacaftor

    Vertex Pharmaceuticals (Australia) Pty.

    Cystic Fibrosis

    phase 1 small molecule completed

    1 trial

  13. Vaporized Marijuana

    BRIGHT MINDS BIOSCIENCES INC.

    Marijuana Usage

    phase 1 small molecule completed

    1 trial

  14. Varenicline

    BRIGHT MINDS BIOSCIENCES INC.

    Drug Addiction

    phase 1 small molecule terminated

    1 trial

  15. Varenicline Tartrate

    BRIGHT MINDS BIOSCIENCES INC.

    Nicotine Addiction

    phase 1 small molecule active

    1 trial

  16. Varenicline, then placebo

    BRIGHT MINDS BIOSCIENCES INC.

    Methamphetamine Addiction

    phase 1 small molecule completed

    1 trial

  17. Vebicorvir (VBR)

    ASSEMBLY BIOSCIENCES, INC.

    Chronic Hepatitis B

    phase 1 small molecule completed

    1 trial

  18. Vedolizumab SC

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    4 trials

  19. Vedolizumab SC

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  20. Vehicle to Methylprednisolone Aceponate Ointment, Methylprednisolone Aceponate Ointment, Advantan® 0,1% Salbe

    Alphapharm Pty Ltd

    Mild to moderate atopic dermatitis

    phase 1 small molecule active

    1 trial

  21. Velusetrag

    Theravance Biopharma Ireland Umited

    Alzheimer's Disease

    phase 1 small molecule completed

    1 trial

  22. Vemurafenib Oral Tablet [Zelboraf]

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    BRAF V600E-mutated /MSS Metastatic Colorectal Cancer

    phase 1 small molecule active

    1 trial

  23. Venetoclax

    Karyopharm Therapeutics Inc

    Diffuse Large B-cell Lymphoma

    phase 1 small molecule completed

    1 trial

  24. Venetoclax

    Kura Oncology

    Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

  25. Venetoclax

    Karyopharm Therapeutics Inc

    Acute Leukemia of Ambiguous Lineage in Relapse

    phase 1 small molecule active

    1 trial

  26. Venezuelan Equine Encephalitis DNA Vaccine

    United Therapeutics Europe Ltd

    Vaccine Reaction

    phase 1 small molecule active

    1 trial

  27. Venlafaxine 25 mg Tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  28. Venlafaxine Hydrochloride

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    3 trials

  29. Verdinexor

    Karyopharm Therapeutics Inc

    Healthy

    phase 1 small molecule terminated

    1 trial

  30. Vicks VapoInhaler

    BRIGHT MINDS BIOSCIENCES INC.

    Opiates

    phase 1 small molecule completed

    1 trial

  31. Viewing e-cigarette ads

    BRIGHT MINDS BIOSCIENCES INC.

    E-Cig Use

    phase 1 other completed

    1 trial

  32. Virus-specific T-cell Immunity for the Treatment of Some Resistant Viral Infections After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

    Istituto Gentili S.r.l.

    Patients who have received an allogeneic haematopoietic stem cell transplant and who have developed post-transplant viral reactivation (CMV, Adenovirus, EBV) resistant to pharmacological therapies.

    phase 1 other active

    1 trial

  33. Visual Sputum Suctioning System

    The First People's Hospital of Lianyungang

    Ineffective Airway Clearance

    phase 1 other active

    1 trial

  34. Vitamin B6-restricted diet + immunotherapy

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Solid Tumor Cancer

    phase 1 other active

    1 trial

  35. Voclosporin

    Aurinia Pharmaceuticals

    Volunteers

    phase 1 small molecule completed

    1 trial

  36. Volanesorsen

    IONIS PHARMACEUTICALS INC

    Abnormalities, Cardiovascular

    phase 1 small molecule completed

    1 trial

  37. Volasertib, low dose, d1q3w

    Boehringer Ingelheim

    Neoplasms

    phase 1 small molecule completed

    1 trial

  38. Vonoprazan

    Phathom Pharmaceuticals

    Gastroesophageal Reflux

    phase 1 small molecule completed

    1 trial

  39. Vonoprazan

    Phathom Pharmaceuticals

    Gastroesophageal Reflux Disease

    phase 1 small molecule completed

    1 trial

  40. Vonoprazan

    Phathom Pharmaceuticals

    Healthy Participants

    phase 1 small molecule terminated

    2 trials

  41. Vonoprazan

    Phathom Pharmaceuticals

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  42. Vonoprazan ODT-1 or ODT-2 without Water

    Phathom Pharmaceuticals

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  43. Vonsetamig

    Regeneron UK Limited

    Lupus Nephritis (LN)

    phase 1 small molecule active

    1 trial

  44. Voriconazole 200mg

    The First People's Hospital of Lianyungang

    Cryptococcal Meningitis

    phase 1 small molecule active

    1 trial

  45. Vortioxetine

    Takeda

    Healthy Adult Participants

    phase 1 small molecule completed

    1 trial

  46. Vortioxetine

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  47. Vortioxetine

    Takeda

    Severe Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  48. Vyxeos

    Jazz Pharmaceuticals Ireland Limited

    Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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