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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

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  1. Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) + Placebo

    Spero Therapeutics

    TQT Study

    phase 1 small molecule completed

    1 trial

  2. Tebipenem pivoxil hydrobromide (TBPM-PI-HBr)

    Spero Therapeutics

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  3. Tebipenem pivoxil hydrobromide (TBPM-PI-HBr)

    Spero Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  4. Tebipenem pivoxil hydrobromide (TBPM-PI-HBr) - Reference

    Spero Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  5. Tebipenem tablet form

    Spero Therapeutics

    Relative Bioavailability

    phase 1 small molecule completed

    1 trial

  6. Tecartus 0.4 - 2 x 10e8 cells dispersion for infusion

    Lacuna Pharma Pty Ltd

    Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r ALL) Relapsed/Refractory B-cell non-Hodgkin lymphoma (r/r NHL)

    phase 1 small molecule active

    1 trial

  7. Teduglutide

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  8. Teduglutide

    Takeda

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  9. Telaprevir

    Vertex Pharmaceuticals (Australia) Pty.

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  10. Telaprevir; Moxifloxacin; Placebo

    Vertex Pharmaceuticals (Australia) Pty.

    Hepatitis C

    phase 1 small molecule completed

    1 trial

  11. Telavancin

    Theravance Biopharma Ireland Umited

    Healthy

    phase 1 small molecule completed

    1 trial

  12. Telotristat Ethyl

    LEXICON PHARMACEUTICALS, INC.

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  13. Telotristat etiprate

    LEXICON PHARMACEUTICALS, INC.

    QT Interval

    phase 1 small molecule completed

    1 trial

  14. Telotristat etiprate

    LEXICON PHARMACEUTICALS, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  15. Telotristat etiprate

    LEXICON PHARMACEUTICALS, INC.

    Drug Interactions

    phase 1 small molecule completed

    2 trials

  16. Tepotinib

    United Therapeutics Europe Ltd

    Advanced Cancer

    phase 1 small molecule active

    1 trial

  17. Terbinafine HCl 250mg tablets

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  18. Test Montelukast

    GlaxoSmithKline

    Respiratory Disorders

    phase 1 small molecule completed

    1 trial

  19. Test drug (T1): CBP-201 injection (pre-filled syringe, 150 mg/1 mL)

    S.L

    Healthy Adult Subjects

    phase 1 mab completed

    1 trial

  20. Test: Favipiravir 200 mg (LOQULAR)

    BRIGHT MINDS BIOSCIENCES INC.

    Bioequivalence

    phase 1 small molecule completed

    1 trial

  21. Tetrahydrobiopterin

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Radiation-Induced Dermatitis

    phase 1 small molecule active

    1 trial

  22. Tetrahydrobiopterin 10 mg/kg

    BioMarin Pharmaceutical Australia Pty Ltd

    Claudication, Intermittent

    phase 1 small molecule active

    1 trial

  23. The 10mg dose group

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  24. The CALiPSO-1 Study: A Study of CNTY-101, a CD19-targeted CAR iNK Cell Product, in Participants with Refractory B cell-mediated Autoimmune Diseases

    Century Therapeutics

    systemic lupus erythematosus [SLE]/lupus nephritis [LN], idiopathic inflammatory myopathy [IIM], and diffuse cutaneous systemic sclerosis [DcSSc]

    phase 1 other active

    1 trial

  25. The Chimeric Antigen Receptor T Cell Immunotherapy (CAR-T)

    Sinobioway Cell Therapy Co.,

    Lymphoma

    phase 1 mab active

    1 trial

  26. The Role of the Amylin Analogue Cagrilintide in Bone Metabolism

    NovoThirteen

    Female (aged between 50-70 years (both included)) with obesity (BMI ≥ 30.0 kg/m2) of post-menopausal state at screening (defined as minimum 12 months of amenorrhea and high levels of follicular stimulating hormone (FSH) ≥16 UI/L. In cases of uncertainty, confirmation of postmenopausal status requires low levels of anti-Müllerian hormone (AMH) and inhibin B).

    phase 1 other active

    1 trial

  27. The bioavailability study of Dapagliflozin

    Laboratorios Tillomed Spain S.L.U

    not applicable (submitted trial is a bioequivalence study

    phase 1 other active

    1 trial

  28. The clinical trial to study a new drug, AP-2.

    Lacuna Pharma Pty Ltd

    ALS and related disorders like frontotemporal dementia and Alexander disease.

    phase 1 other active

    1 trial

  29. The detection of tumor-associated fibrosis in colorectal peritoneal metastases by FAPI-PET (TROMPET)

    Disc Medicine

    Metastatic colorectal cancer

    phase 1 other active

    1 trial

  30. The goal of this clinical study is to learn more about the safety and dosing of the study drugs, KITE-363 and KITE-753, in participants with relapsed and/or refractory B-cell lymphoma.

    Lacuna Pharma Pty Ltd

    Relapsed and/or Refractory B-cell Lymphoma

    phase 1 other active

    1 trial

  31. The pivotal bioequivalence study comparing the test product to the reference product, which belong to the group of medicines used in the treatment of type 2 diabetes mellitus when the condition cannot be adequately controlled by diet and exercise alone.

    Lacuna Pharma Pty Ltd

    Not applicable (submitted trial is a BE study in healthy subjects).

    phase 1 other active

    1 trial

  32. The pivotal bioequivalence study comparing the test product to the reference product, which belong to the group of medicines used in treatment of uncomplicated lower urinary tract infections.

    Sciencepharma Sp. z o.o

    Not applicable (submitted trial is a bioequivalence in healthy subjects)

    phase 1 other active

    1 trial

  33. The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment and prevention of Influenza.

    Lacuna Pharma Pty Ltd

    influenza

    phase 1 other active

    1 trial

  34. The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment of schizophrenia in adult patients.

    Lacuna Pharma Pty Ltd

    Not applicable (submitted trial is a BE study in healthy subjects).

    phase 1 other active

    1 trial

  35. The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment of schizophrenia in adults patients.

    Lacuna Pharma Pty Ltd

    Bioequivalence study under fasting conditions

    phase 1 other active

    1 trial

  36. The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment of type 2 diabetes mellitus in adults and children aged 10 years and above, and heart failure and chronic kidney disease in adults patiens.

    Lacuna Pharma Pty Ltd

    Not applicable (submitted trial is a BE study in healthy subjects.

    phase 1 other active

    1 trial

  37. Therapeutic Workplace Intervention

    BRIGHT MINDS BIOSCIENCES INC.

    Drug Addiction

    phase 1 other completed

    1 trial

  38. This is a clinical trial (study), to be conducted at multiple clinical sites, of an oral study drug (EP262) that will be investigated in adult participants with Chronic Inducible Urticaria (CIndU) to assess if it is safe and improves reactions to known CIndU triggers.

    Lacuna Pharma Pty Ltd

    Chronic Inducible Urticaria

    phase 1 other active

    1 trial

  39. This is clinical study to test, for the first time in people, the safety (any good or bad effects), how long the drug can stay in the body and if it can control the disease of people diagnosed with advanced cancer that has not responded to treatment, has returned after it has been treated, or cannot be treated by surgery, drugs, or any other known treatments.

    Celgene Europe Limited

    Part C: advanced or unresectable STs (Spain only), Part B : r/r diffuse large B cell lymphoma (DLBCL) (Cohort 1), advanced basal cell carcinoma (BCC) (Cohort 2), r/r DLBCL under an alternative dosing regimen (Cohort 3), Part A: advanced or unresectable solid tumors (STs) and relapsed and/or refractory (r/r) advanced non-Hodgkin's lymphomas (NHLs)

    phase 1 other active

    1 trial

  40. This study aims to find the best dose of BI 907828 (brigimadlin) in patients with different types of advanced cancer (solid tumors)

    Boehringer Ingelheim

    Advanced or metastatic solid tumors

    phase 1 other active

    1 trial

  41. ThisCART19A

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Autoimmune Hemolytic Anemia

    phase 1 mab active

    1 trial

  42. ThisCART19A

    The First People's Hospital of Lianyungang

    Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

    phase 1 small molecule active

    1 trial

  43. ThisCART19A with Dose Level 1

    The First People's Hospital of Lianyungang

    CAR

    phase 1 small molecule active

    1 trial

  44. ThisCART22 cells injection

    The First People's Hospital of Lianyungang

    B Cell Malignancy

    phase 1 mab active

    1 trial

  45. ThisCART7 cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    T-Acute Lymphoblastic Leukemia

    phase 1 mab active

    1 trial

  46. Tiotropium

    BRIGHT MINDS BIOSCIENCES INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  47. Tipifarnib

    Kura Oncology

    NSCLC

    phase 1 small molecule terminated

    1 trial

  48. Tipifarnib

    Kura Oncology

    Advanced Solid Tumor

    phase 1 small molecule terminated

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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