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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 76 of 99

  1. SECRET-HF: Treatment of Non-ischemic Dilated Cardiomyopathies by Intravenous Infusions of the Extracellular Vesicle-Enriched Secretome of Cardiovascular Progenitor Cells

    Pari Pharma GmbH

    Non-ischemic Dilated Cardiomyopathies

    phase 1 other active

    1 trial

  2. SENTI-202

    Essential Pharma Limited

    AML/MDS

    phase 1 mab active

    1 trial

  3. SER-214

    Serina Therapeutics

    Parkinson's Disease

    phase 1 small molecule active

    1 trial

  4. SER-252 (PEOZ-apomorphine)

    Serina Therapeutics

    PARKINSON DISEASE (Disorder)

    phase 1 small molecule active

    1 trial

  5. SER-262

    Seres Therapeutics

    Clostridium Difficile Infection

    phase 1 small molecule completed

    1 trial

  6. SER-287

    Seres Therapeutics

    Ulcerative Colitis

    phase 1 small molecule completed

    1 trial

  7. SGT-212

    Solid Biosciences

    Friedreich's Ataxia (FA)

    phase 1 small molecule active

    1 trial

  8. SGT-501

    Solid Biosciences

    Catecholaminergic Polymorphic Ventricular Tachycardia

    phase 1 small molecule active

    1 trial

  9. SHP465 12.5mg

    Takeda

    Attention Deficit Hyperactivity Disorder (ADHD)

    phase 1 small molecule completed

    1 trial

  10. SHP639 (n=60)

    Takeda

    Primary Open-angle Glaucoma (POAG)

    phase 1 small molecule completed

    1 trial

  11. SHP643

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  12. SHP681

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  13. SHR-1501

    Jian Li

    Advanced Malignancies

    phase 1 small molecule completed

    1 trial

  14. SHR1459 tablet

    Jian Li

    B-cell Tumors

    phase 1 small molecule completed

    1 trial

  15. SHR2554 and Itraconazole

    Jian Li

    Healthy Adult Subjects

    phase 1 small molecule completed

    1 trial

  16. SIBP-A13 formulation for injection

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Advanced Solid Tumor

    phase 1 small molecule active

    1 trial

  17. SIE-1

    Laboratorios Tillomed Spain S.L.U

    Hormone receptor-positive early breast cancer in post-menopausal women

    phase 1 other active

    1 trial

  18. SIG001

    The First People's Hospital of Lianyungang

    Neoplams

    phase 1 mab active

    1 trial

  19. SION-451

    Sionna Therapeutics

    Cystic Fibrosis (CF)

    phase 1 small molecule active

    1 trial

  20. SKY0402

    Pacira Ireland Limited

    Postoperative Pain Management

    phase 1 small molecule completed

    1 trial

  21. SKY0402

    Pacira Ireland Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  22. SKY0402 300mg in healthy patients

    Pacira Ireland Limited

    Pain

    phase 1 small molecule completed

    1 trial

  23. SL TNX-102 2.4 mg at pH 3.5

    Tonix Pharmaceuticals Holding

    Healthy Adults

    phase 1 small molecule completed

    1 trial

  24. SL TNX-102 at 2.4 mg

    Tonix Pharmaceuticals Holding

    Healthy Adults

    phase 1 small molecule completed

    1 trial

  25. SLN124

    Silence Therapeutics plc

    Non-transfusion-dependent Thalassemia

    phase 1 small molecule completed

    1 trial

  26. SLN124

    Silence Therapeutics plc

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  27. SLN124 is a GalNAc conjugated double stranded fully modified siRNA. Sodium chloride 0.9% w/v is used as Placebo

    Silence Therapeutics plc

    Non-transfusion-dependent Thalassemia

    phase 1 small molecule terminated

    1 trial

  28. SLN360

    Silence Therapeutics plc

    Hyperlipidemias

    phase 1 small molecule completed

    1 trial

  29. SMT C1100

    Summit Therapeutics

    Muscular Dystrophy, Duchenne

    phase 1 small molecule completed

    1 trial

  30. SMT C1100

    Summit Therapeutics

    Duchenne Muscular Dystrophy

    phase 1 small molecule completed

    1 trial

  31. SN301A

    Essential Pharma Limited

    Hepatocellular Carcinoma (HCC)

    phase 1 mab active

    1 trial

  32. SNDX-275

    Syndax Pharmaceuticals

    Breast Cancer

    phase 1 small molecule terminated

    1 trial

  33. SNDX-5613

    Syndax Pharmaceuticals

    Acute Myeloid Leukemias

    phase 1 small molecule active

    1 trial

  34. SOC + TSC-100

    TScan Therapeutics

    AML

    phase 1 small molecule active

    1 trial

  35. SOF/VEL/VOX

    Gilead Sciences Ireland UC

    HCV Infection

    phase 1 small molecule completed

    1 trial

  36. SOM 230 / Pasireotide

    United Therapeutics Europe Ltd

    Atypical Ductal Breast Hyperplasia

    phase 1 small molecule completed

    1 trial

  37. SPARC1210

    Advanced Accelerator Applications

    Breast Cancer

    phase 1 small molecule terminated

    1 trial

  38. SPARC1613

    Advanced Accelerator Applications

    Recurrent or Metastatic Breast Cancer

    phase 1 small molecule completed

    1 trial

  39. SPD422

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  40. SPD489 (Lisdexamfetamine dimesylate)

    Takeda

    Schizophrenia

    phase 1 small molecule completed

    1 trial

  41. SPD503

    Takeda

    Healthy

    phase 1 small molecule completed

    2 trials

  42. SPD544

    Takeda

    ADHD

    phase 1 small molecule completed

    1 trial

  43. SPECT/CT imaging of FPI-2505 in patients with solid tumours; a phase 0 molecular imaging basket trial (SCOPE-study).

    Lacuna Pharma Pty Ltd

    small cell lung cancer, non-smallcell lung cancer, colorectal cancer, breast cancer, Pancreatic cancer and gastric cancer

    phase 1 other active

    1 trial

  44. SPGL008

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Advanced Malignant Tumors

    phase 1 small molecule active

    1 trial

  45. SPN-804O

    SUPERNUS PHARMACEUTICALS, INC.

    Epilepsies, Partial

    phase 1 small molecule completed

    1 trial

  46. SPN-810M

    SUPERNUS PHARMACEUTICALS, INC.

    Impulsive Aggression Comorbid With ADHD

    phase 1 small molecule completed

    1 trial

  47. SPN-817, Treatment B

    SUPERNUS PHARMACEUTICALS, INC.

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  48. SPR206

    Spero Therapeutics

    Renal Impairment

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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