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Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

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NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

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  1. Short-Term Linvoseltamab Treatment, on Top of Chronic Dupilumab Treatment, for Adults with Severe Immunoglobulin E (IgE)-Mediated Food Allergy

    Lacuna Pharma Pty Ltd

    Severe IgE-mediated food allergy

    phase 1 other active

    1 trial

  2. Sialic Acid Extended Release (SA-ER) Tablets

    Ultragenyx UK Limited

    Hereditary Inclusion Body Myopathy (HIBM)

    phase 1 small molecule completed

    1 trial

  3. Signature Cord Prime

    Forteo

    Osteoarthritis, Knee

    phase 1 mab active

    1 trial

  4. Silodosin

    Hospital Authority, Hong Kong

    Benign Prostatic Hyperplasia

    phase 1 small molecule completed

    1 trial

  5. Simvastatin

    Aurinia Pharmaceuticals

    Drug-drug Interaction

    phase 1 small molecule completed

    1 trial

  6. Simvastatin

    United Therapeutics Europe Ltd

    Recurrent Acute Pancreatitis

    phase 1 small molecule active

    1 trial

  7. Simvastatin

    Madrigal Pharmaceuticals EU Limited

    Healthy

    phase 1 small molecule completed

    1 trial

  8. Simvastatin

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  9. Single Ascending Dose of SAB-176

    SAB Biotherapeutics

    PHA1A

    phase 1 small molecule active

    1 trial

  10. Single Dose Pharmacokinetics and Relative Bioavailability of Sayana Press via Upper Arm Injection Relative to Anterior Thigh and Abdomen

    Pfizer Australia Pty Ltd

    long-term female contraception

    phase 1 other active

    1 trial

  11. Single FT1050 treated UCB unit

    Zafatek

    Non-Hodgkin's Lymphoma (NHL)

    phase 1 mab completed

    1 trial

  12. Single agent of cyclophosphamide, doxorubicin, epirubicin, fluorouracil and methotrexate

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Breast Cancer

    phase 1 small molecule active

    1 trial

  13. Single and multiple ascending dose of ZP9830 in healthy participants

    Zealand Pharma A/S

    Autoimmune diseases

    phase 1 other active

    1 trial

  14. Single dose intravenous injection of BBM 002

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Hemophilia A

    phase 1 gene therapy active

    1 trial

  15. Single dose oral bioequivalence study of Cladribine 10 mg Tablets and Mavenclad® 10 mg tablets (Cladribine) in healthy adult human subjects under fed conditions

    Lacuna Pharma Pty Ltd

    No therapeutic indication in the current trial with healthy volunteers.

    phase 1 other active

    1 trial

  16. Single dose, open-label, laboratory blinded, randomized, 2-treatment, 2-period, 2-sequence, crossover, pivotal study to assess the comparative bioavailability of Test Product Dapagliflozin/metformin hydrochloride 5 mg/1000 mg film-coated tablets to Reference Product Xigduo 5 mg/1000 mg film-coated tablets in healthy adult male and female subjects under fed conditions.

    Laboratorios Tillomed Spain S.L.U

    Bioavailability study in healthy volunteers under fed conditions.

    phase 1 other active

    1 trial

  17. Single dose, open-label, laboratory blinded, randomized, 2-treatment, 2-period, 2-sequence, crossover, pivotal study to assess the relative bioavailability of Test Product Naproxen sodium 660 mg modified release tablets to Reference Product Actromadol 660 mg Modified-Release tablets in healthy adult male and female subjects under fed conditions.

    Laboratorios Tillomed Spain S.L.U

    No medical condition

    phase 1 other active

    1 trial

  18. Single dose, open-label, laboratory blinded, randomized, 2-treatment, 2-period, 2-sequence, crossover, pivotal study to assess the relative bioavailability of Test Product Naproxen sodium 660 mg modified release tablets to Reference Product Actromadol 660 mg Modified-Release tablets in healthy adult male and female subjects under fasting conditions.s.

    Laboratorios Tillomed Spain S.L.U

    Bioavailability study in healthy volunteers under fasting conditions.

    phase 1 other active

    1 trial

  19. Single microdose trial - CXCR4 PET tracer - Pharmacokinetics and pharmacodynamics of [68Ga]Ga-R54, a CXCR4-targeted radiopharmaceutical in patients with advanced solid tumors.

    Fondazione Telethon ETS

    Advanced solid neoplasm (breast, lung, colon, ovary, pancreas) characterized by positive CXCR4 expression by immunohistochemistry

    phase 1 other active

    1 trial

  20. Single-Ascending Doses of 2-Methoxyestradiol in Healthy Non-Pregnant Female Subjects.

    Laboratorios Tillomed Spain S.L.U

    No medical condition.

    phase 1 other active

    1 trial

  21. Single-Dose Study in Healthy Participants to Compare the Bioavailability of One Film-Coated Mini-Tablet of Indapamide SR 1.5 mg versus One Film-Coated Tablet of Indapamide IR 2.5 mg Under Fasting Conditions, and to Compare the Bioavailability of One Film-Coated Mini-Tablet of Indapamide SR 1.5 mg Under Fasting versus Fed Conditions.

    The George Institute

    No medical condition.

    phase 1 other active

    1 trial

  22. Single-center, single-dose, open-label, laboratory-blinded, randomized, two-treatment, two-period bioequivalence (BE) study comparing the Test Product Apixaban 5 mg film-coated tablets (MEDITOP) with the Reference Product Eliquis 5 mg film-coated tablets (Bristol-Myers Squibb/Pfizer) under fasting conditions.

    Pari Pharma GmbH

    Comparative bioequivalence study in healthy volunteers under fasting conditions.

    phase 1 other active

    1 trial

  23. Sinovac PCV24 formulation 1

    Sinovac Research and Development Co.,

    Pneumococcal Infectious Disease

    phase 1 mab completed

    2 trials

  24. Small RNA sequencing

    Inhibitor Therapeutics

    Fertility

    phase 1 gene therapy completed

    1 trial

  25. Sodium Zirconium Cyclosilicate (ZS)

    AstraZeneca

    Hyperkalemia

    phase 1 small molecule completed

    1 trial

  26. Sodium phenylbutyrate

    ZEVRA THERAPEUTICS, INC.

    Combined D,L-2-hydroxyglutaric Aciduria

    phase 1 small molecule active

    1 trial

  27. Solriamfetol 150 mg Oral Tablet

    Axsome Therapeutics

    Narcolepsy

    phase 1 small molecule completed

    1 trial

  28. Sonelokimab

    MoonLake Immunotherapeutics

    Relative Bioequivalence

    phase 1 small molecule completed

    1 trial

  29. Sonodynamic therapy (SDT)

    The First People's Hospital of Lianyungang

    Carotid Atherosclerosis

    phase 1 other completed

    1 trial

  30. Sonrotoclax

    BEONE MEDICINES AUS PTY LTD

    Mature B-Cell Malignancies

    phase 1 small molecule active

    1 trial

  31. Sotagliflozin

    LEXICON PHARMACEUTICALS, INC.

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  32. Sotagliflozin (SOTA) followed by 3 drugs in a random order

    LEXICON PHARMACEUTICALS, INC.

    Platelet Function and Reactivity Tests

    phase 1 small molecule active

    1 trial

  33. Soticlestat

    Takeda

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  34. Soticlestat

    Takeda

    Healthy Volunteers

    phase 1 small molecule terminated

    4 trials

  35. Soticlestat 300 mg

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  36. Sotrovimab

    Vir Biotechnology

    COVID-19 Infection

    phase 1 mab terminated

    1 trial

  37. Spermine

    Paul Hartmann Pty Ltd

    Premature Birth

    phase 1 mab completed

    1 trial

  38. Spesolimab

    Boehringer Ingelheim

    Psoriasis

    phase 1 small molecule completed

    1 trial

  39. Spinraza 12 mg solution for injection

    Biogen

    Spinal Muscular Atrophy

    phase 1 small molecule active

    1 trial

  40. Spironolactone

    BRIGHT MINDS BIOSCIENCES INC.

    Alcohol Use Disorder

    phase 1 small molecule active

    1 trial

  41. Sporozoite Challenge Model for Plasmodium vivax in Humans

    BRIGHT MINDS BIOSCIENCES INC.

    Malaria, Vivax

    phase 1 mab completed

    1 trial

  42. Standardized Research E-cigarette (SREC)

    BRIGHT MINDS BIOSCIENCES INC.

    Smoking, Cigarette

    phase 1 small molecule active

    1 trial

  43. Stelara

    Rani Therapeutics Holdings

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  44. Stem Cell

    EuroGen Pharmaceuticals Ltd

    Neurological; Disorder, Nervous System

    phase 1 mab terminated

    1 trial

  45. Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2

    Arrowhead Pharmaceuticals Ireland Limited

    spinocerebellar ataxia type 2

    phase 1 other active

    1 trial

  46. Study of Abemaciclib with Pembrolizumab in Patients with Stage IV Lung Cancer or Breast Cancer

    Eli Lilly Co.

    Lung Cancer or Breast Cancer

    phase 1 other active

    1 trial

  47. Study of BGB-11417 in Patients with Mature B Cell Malignancies

    BEONE MEDICINES AUS PTY LTD

    Mature B Cell Malignancies

    phase 1 other active

    1 trial

  48. Study of DFF332 alone and in combination with Everolimus or Immuno-oncology therapies in patients with renal cell carcinoma and other selected tumors.

    Novartis Pharmaceuticals

    Advanced, relapsed Clear Cell Renal Cell Carcinoma

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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