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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

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NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

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  1. Randomised, bioequivalence clinical trial of rasagiline 1 mg capsules vs rasagiline 1 mg tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.

    Laboratorios Tillomed Spain S.L.U

    Parkinson´s disease

    phase 1 other active

    1 trial

  2. Randomised, crossover bioequivalence clinical trial of donepezil 5 mg capsules vs donepezil 5 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions

    Laboratorios Tillomed Spain S.L.U

    Alzheimer's disease

    phase 1 other active

    1 trial

  3. Randomised, crossover bioequivalence clinical trial of edoxaban 60 mg tablets versus edoxaban 60 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

    Laboratorios Tillomed Spain S.L.U

    Healthy volunteers

    phase 1 other active

    1 trial

  4. Randomised, crossover bioequivalence clinical trial of escitalopram 10 mg capsules versus escitalopram 10 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

    Laboratorios Tillomed Spain S.L.U

    Antidepressants

    phase 1 other active

    1 trial

  5. Randomised, crossover bioequivalence clinical trial of linagliptin/metformin 2.5 mg/1000 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fed conditions.

    Laboratorios Tillomed Spain S.L.U

    diabetes

    phase 1 other active

    1 trial

  6. Randomised, crossover bioequivalence clinical trial of memantine 20 mg capsules versus memantine 20 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

    Laboratorios Tillomed Spain S.L.U

    Alzheimer’s disease

    phase 1 other active

    1 trial

  7. Randomised, crossover bioequivalence clinical trial of vortioxetine 20 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

    Laboratorios Tillomed Spain S.L.U

    Antidepressant

    phase 1 other active

    1 trial

  8. Randomised, relative bioavailability clinical trial of amylmetacresol, dichlorobenzyl alcohol, lidocaine and vitamin c lozenges after a single oral dose administration to healthy volunteers under fasting conditions in a crossover design.

    Lacuna Pharma Pty Ltd

    healthy volunteer

    phase 1 other active

    1 trial

  9. Randomized, double-blind, placebo-controlled, two-part study assessing the safety, tolerability and pharmacokinetics of BP1.7881 administered as higher doses, after single ascending doses (Part I) and multiple ascending doses (Part II), including the assessment of BP1.7881 on cardiac repolarization, in healthy subjects.

    Bioprojet Pharma

    Eosinophilic esophagitis

    phase 1 other active

    1 trial

  10. Randomized, open-label, laboratory-blinded, balanced, single dose, 3-treatment, 6-sequence, 3-period crossover comparative bioavailability study comparing Finerenone, 20 mg, film-coated tablets (Prototype 1, Prototype 2) and Kerendia, 20 mg, film-coated tablets under fasting conditions in healthy participants.

    Lacuna Pharma Pty Ltd

    Comparative bioavailability study under fasting conditions

    phase 1 other active

    1 trial

  11. Randomized, open-label, replicated single-dose, 4-period, 2-sequence crossover study to assess the comparative bioavailability of test product Amlodipine/Valsartan/Hydrochlorothiazide 10 mg/160 mg/12.5 mg film-coated tablets to reference product Exforge HCT 10 mg/160 mg/12.5 mg film-coated tablets in healthy male and female subjects under fasting conditions.

    Lacuna Pharma Pty Ltd

    not applicable (submitted trial is bioavailability)

    phase 1 other active

    1 trial

  12. Randomized, open-label, single dose, two-period, two-treatment, cross-over bioequivalence study comparing test product Rivaroxaban/Acetylsalicylic acid, tablet, 2.5 mg/50 mg (given as two tablets) to reference product Xarelto 2.5 mg film-coated tablets (given as two tablets) and Aspirin® N 100 mg tablet in healthy male and female subjects under fasting conditions.

    Lacuna Pharma Pty Ltd

    not applicable (submitted trial is a bioequivalence in healthy subjects)

    phase 1 other active

    1 trial

  13. Randomized, open-label, single-dose, two-period, cross-over, bioequivalence study comparing Linagliptin 5 mg film-coated tablets (Vipharm S.A.) to Trajenta® 5 mg film-coated tablets (Boehringer Ingelheim) in healthy volunteers under fasting conditions.

    Alphapharm Pty Ltd

    Bioequivalence study in healthy volunteers under fasting conditions

    phase 1 other active

    1 trial

  14. RaniPill capsule containing octreotide

    Rani Therapeutics Holdings

    Healthy Volunteers

    phase 1 other completed

    1 trial

  15. Ranolazine

    BRIGHT MINDS BIOSCIENCES INC.

    Drug-induced QT Prolongation

    phase 1 small molecule completed

    1 trial

  16. Rapamycin

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Graves Ophthalmopathy

    phase 1 small molecule active

    1 trial

  17. Recombinant ADAMTS13

    Takeda

    Hereditary Thrombotic Thrombocytopenic Purpura (TTP)

    phase 1 small molecule completed

    1 trial

  18. Recombinant Humanized Anti-IL-36R Monoclonal antibody and Placebo

    Shanghai University of Traditional Chinese Medicine

    Healthy

    phase 1 small molecule completed

    1 trial

  19. Recombinant NV-A01 adenovirus injection

    The First People's Hospital of Lianyungang

    Advanced Glioblastoma Patients

    phase 1 small molecule active

    1 trial

  20. Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    COVID-19

    phase 1 mab completed

    1 trial

  21. Recombinant SARS-CoV-2 Fusion Protein Vaccine

    Livzon Pharmaceutical Group

    COVID19

    phase 1 mab completed

    1 trial

  22. Recombinant adeno-associated virus administration

    Kunming Hope of Health Hospital

    Menkes Syndrome

    phase 1 small molecule terminated

    1 trial

  23. Recombinant erythropoietin stimulating protein

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Chronic Renal Failure

    phase 1 small molecule active

    1 trial

  24. Recombinant human C1 esterase inhibitor

    Takeda

    Hereditary Angioedema (HAE)

    phase 1 small molecule completed

    1 trial

  25. Recombinant human arginase 1 Peg5000

    International Peace Maternity and Child Health Hospital

    Leukemia

    phase 1 small molecule terminated

    1 trial

  26. Recombinant human hyaluronidase PH20 (rHuPH20)

    HALOZYME THERAPEUTICS, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  27. Recombinant human thrombopoietin

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Liver Cirrhosis

    phase 1 small molecule active

    1 trial

  28. Recombinant human tissue kallikrein

    DiaMedica Therapeutics

    Stroke

    phase 1 small molecule completed

    1 trial

  29. Recombinant oncolytic herpes simplex virus type Ⅰ (R130)

    Shanghai University of Traditional Chinese Medicine

    Osteosarcoma

    phase 1 small molecule active

    1 trial

  30. Recombinant von Willebrand factor : recombinant FVIII (rVWF:rFVIII)

    Takeda

    Von Willebrand Disease

    phase 1 mab completed

    1 trial

  31. Refametinib (BAY86-9766)

    Bayer HealthCare AG

    Neoplasms

    phase 1 small molecule completed

    1 trial

  32. Reference, Patch location thigh, batch 1

    BRIGHT MINDS BIOSCIENCES INC.

    Bioequivalence

    phase 1 small molecule completed

    1 trial

  33. Regorafenib in combination with temozolomide with or without radiotherapy in patients with newly diagnosed MGMT-Methylated, IDH wild-type glioblastoma. A phase I dose-finding study (REGOMA-2).

    Istituto Gentili S.r.l.

    MGMT-Methylated, IDH wild-type glioblastoma

    phase 1 other active

    1 trial

  34. Rehabilitation

    United Therapeutics Europe Ltd

    Stroke

    phase 1 other completed

    1 trial

  35. Relacorilant

    CORCEPT THERAPEUTICS INC

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  36. Relacorilant

    CORCEPT THERAPEUTICS INC

    Adrenocortical Carcinoma

    phase 1 small molecule completed

    1 trial

  37. Relacorilant

    CORCEPT THERAPEUTICS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  38. Relacorilant (3x100 mg softgel capsules)

    CORCEPT THERAPEUTICS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  39. Relacorilant 350mg

    CORCEPT THERAPEUTICS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  40. Relacorilant Fasted

    CORCEPT THERAPEUTICS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  41. Relacorilant under fasted conditions

    CORCEPT THERAPEUTICS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  42. Relative bioavailability and safety study of pasireotide after a single-dose subcutaneous administration in the arm or in the thigh compared to in the abdomen using a ServoPen in healthy subjects.

    Recordati Ireland

    Post-bariatric hypoglycaemia

    phase 1 other active

    1 trial

  43. Repetitive Transcranial Magnetic Stimulation

    BRIGHT MINDS BIOSCIENCES INC.

    Cannabis Use

    phase 1 other terminated

    1 trial

  44. Replens and coconut oil

    Summit Therapeutics

    Genitourinary Abnormality

    phase 1 other terminated

    1 trial

  45. Repomol, Metronidazol ”Baxter” Viaflo, infusionsvæske, opløsning, Saline Solution Basi 9 mg/ml solution for infusion, Fosfomycin "Infectopharm", pulver til infusionsvæske, opløsning 40 mg/ml

    Lacuna Pharma Pty Ltd

    peritonitis

    phase 1 small molecule active

    1 trial

  46. Repurposed Drugs in Research and Cancer Clinical Trials. The ReDiReCCT trial Vemurafenib

    Disc Medicine

    Glioma

    phase 1 other active

    1 trial

  47. Research ENDS S-TA-U001

    BRIGHT MINDS BIOSCIENCES INC.

    Cigarette Smoking

    phase 1 small molecule completed

    1 trial

  48. Reserpine

    BRIGHT MINDS BIOSCIENCES INC.

    Amphetamine-Related Disorders

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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