🇺🇸 FDA

Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 78 of 99

  1. SZ011 CAR-NK

    The First People's Hospital of Lianyungang

    Advanced Triple Negative Breast Cancer

    phase 1 small molecule active

    1 trial

  2. SafeMedWaste

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Use Disorder

    phase 1 other active

    1 trial

  3. Safety Assessment of 10-Day Daily Bucco-Oral Administration of Transfer Factor in Healthy Adult Human Subjects

    s.r.o.

    healthy subjects, It is used in conditions with decreased immunity to enhance it e.g. in case of recurrent and chronic viral infections.

    phase 1 other active

    1 trial

  4. Safety Study to Compare the Gastrointestinal Tolerability of Oral Tegomil Fumarate and Dimethyl Fumarate (Tecfidera®) in Healthy Volunteers.

    NEURAXPHARM AUSTRALIA PTY LIMITED

    Multiple Sclerosis

    phase 1 other active

    1 trial

  5. Safety and Early Signs of Efficacy of IL12-L19L19

    Philogen S.p.A.

    Advanced or metastatic carcinomas after previous immune checkpoint blockade therapy

    phase 1 other active

    1 trial

  6. Safety and Tolerability of a Timolol Releasing Intraocular Implant in Subjects With Primary Open-angle Glaucoma

    Lacuna Pharma Pty Ltd

    Glaucoma

    phase 1 other active

    1 trial

  7. Safety and immune responses after vaccination with two investigational RNA-based vaccines against tuberculosis in healthy volunteers

    BioNTech SE

    Tuberculosis

    phase 1 other active

    1 trial

  8. Safety and tolerability of medicated chewing gum with sodium alginate, calcium carbonate and sodium bicarbonate.

    Laboratorios Tillomed Spain S.L.U

    No medical condition.

    phase 1 other active

    1 trial

  9. Safety and tolerability of single and multiple ascending doses of lunsekimig (SAR443765) in healthy participants

    Sanofi-aventis Healthcare Pty Ltd

    Asthma

    phase 1 other active

    1 trial

  10. Safety of TEG001 in patients with r/r AML/high-risk MDS or r/r MM

    Disc Medicine

    Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Multiple Myeloma (MM)

    phase 1 other active

    1 trial

  11. Safety, Tolerability and Pharmacokinetic Profile of TPT0301 in Healthy Volunteers

    Alphapharm Pty Ltd

    adjunctive neuropathic pain

    phase 1 other active

    1 trial

  12. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AB-101 Following Oral Administration in Healthy and Chronic Hepatitis B Subjects

    Arbutus Biopharma Corp

    Chronic hepatitis B virus Infection

    phase 1 other active

    1 trial

  13. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-1076986 in Healthy Adults.

    NEUROCRINE BIOSCIENCES INC

    Movement disorders

    phase 1 other active

    1 trial

  14. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-1117570 in Healthy Adults

    NEUROCRINE BIOSCIENCES INC

    Neurological and neuropsychiatric conditions

    phase 1 other active

    1 trial

  15. Safety, pharmacokinetics and pharmacodynamics study of Leucettinib-21 in healthy subjects, Down Syndrom and Alzheimer patients

    Lacuna Pharma Pty Ltd

    A Phase 1, Randomized, Double-Blind, Placebo-Controlled, First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses and Food Effect of Leucettinib-21 in Healthy Male Subjects, followed by an open single dose of Leucettinib-21 in Down Syndrome individuals, and patients with Alzheimer’s disease

    phase 1 other active

    1 trial

  16. Safety, tolerability, pharmacokinetics, and pharmacodynamics of intravenous and subcutaneous multiple rising doses of BI 765250 versus placebo in trial participants with moderate to severe plaque psoriasis (double-blind, randomised, placebo-controlled, parallel-group design)

    Boehringer Ingelheim

    Plaque psoriasis

    phase 1 other active

    1 trial

  17. Saline

    BRIGHT MINDS BIOSCIENCES INC.

    Nicotine Addiction

    phase 1 small molecule completed

    1 trial

  18. Salmeterol

    BRIGHT MINDS BIOSCIENCES INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  19. Salvianolic Acid A

    The First People's Hospital of Lianyungang

    Neuropathy of Diabetes

    phase 1 small molecule active

    1 trial

  20. Sanchi-Tongshu Capsule (Enteric coated pellets)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Healthy

    phase 1 small molecule completed

    1 trial

  21. Sapanisertib

    Takeda

    Non-hematologic Malignancy

    phase 1 small molecule completed

    1 trial

  22. Sapropterin dihydrochloride tablets

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Head and Neck Squamous Cell Carcinoma

    phase 1 small molecule active

    1 trial

  23. Sargramostim

    Ultragenyx UK Limited

    Autoimmune Pulmonary Alveolar Proteinosis

    phase 1 small molecule completed

    1 trial

  24. Sativex

    Jazz Pharmaceuticals Ireland Limited

    Food Effect

    phase 1 small molecule completed

    1 trial

  25. Sativex

    Jazz Pharmaceuticals Ireland Limited

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  26. Sativex

    Jazz Pharmaceuticals Ireland Limited

    Evaluation of Abuse Potential of Sativex

    phase 1 small molecule completed

    1 trial

  27. Sativex and rifampicin

    Jazz Pharmaceuticals Ireland Limited

    Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Known Inducer of CYP3A4

    phase 1 small molecule completed

    1 trial

  28. Sativex(Registered Trademark)

    BRIGHT MINDS BIOSCIENCES INC.

    Cannabis

    phase 1 small molecule completed

    1 trial

  29. Sativex® (Treatment A)

    Jazz Pharmaceuticals Ireland Limited

    Healthy Subjects

    phase 1 small molecule completed

    1 trial

  30. Satraplatin in combo with vinorelbine

    BRIGHT MINDS BIOSCIENCES INC.

    Advanced Solid Tumors

    phase 1 small molecule active

    1 trial

  31. Schedule A

    LEXICON PHARMACEUTICALS, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  32. Scopolamine

    Takeda

    Healthy Volunteers

    phase 1 small molecule terminated

    1 trial

  33. Segesterone Acetate and Ethinyl Estradiol

    TherapeuticsMD

    Contraception

    phase 1 small molecule completed

    1 trial

  34. Segesterone Acetate and Ethinyl Estradiol

    TherapeuticsMD

    Women

    phase 1 small molecule completed

    1 trial

  35. Selinexor

    Karyopharm Therapeutics Inc

    Solid Tumor

    phase 1 small molecule completed

    1 trial

  36. Selinexor

    Karyopharm Therapeutics Inc

    Amyloid

    phase 1 small molecule terminated

    1 trial

  37. Selinexor

    Karyopharm Therapeutics Inc

    Colorectal Neoplasm

    phase 1 small molecule terminated

    1 trial

  38. Selinexor

    Karyopharm Therapeutics Inc

    Liposarcoma

    phase 1 small molecule terminated

    1 trial

  39. Selinexor

    Karyopharm Therapeutics Inc

    Prolymphocytic Leukemia

    phase 1 small molecule completed

    1 trial

  40. Selinexor

    Karyopharm Therapeutics Inc

    Refractory Multiple Myeloma

    phase 1 small molecule active

    1 trial

  41. Selinexor

    Karyopharm Therapeutics Inc

    Soft Tissue Sarcoma

    phase 1 small molecule completed

    1 trial

  42. Selinexor Pill

    Karyopharm Therapeutics Inc

    Hepatocellular Carcinoma

    phase 1 small molecule terminated

    1 trial

  43. Semaglutide Extended-release for Injectable Suspension, 1 mg

    BRIGHT MINDS BIOSCIENCES INC.

    Diabetes Mellitus, Type 2

    phase 1 small molecule active

    1 trial

  44. Serine（Oral）

    The First People's Hospital of Lianyungang

    Advanced Colorectal Cancer

    phase 1 small molecule active

    1 trial

  45. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Renal Insufficiency

    phase 1 small molecule completed

    1 trial

  46. Shenkang decoction

    The First People's Hospital of Lianyungang

    Chronic Renal Failure

    phase 1 small molecule completed

    1 trial

  47. Shigella sonnei 53G

    United Therapeutics Europe Ltd

    Healthy

    phase 1 mab completed

    1 trial

  48. Shigella sonnei 53G

    United Therapeutics Europe Ltd

    Shigellosis

    phase 1 mab active

    2 trials

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.