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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. MK-4646 Single Ascending Dose Study and DDI in Healthy Participants

    Merck Sharp and Dohme

    HIV infection

    phase 1 other active

    1 trial

  2. MK-7091 Formulations Study in Healthy Adult Participants

    Merck Sharp and Dohme

    Hypercholesterolemia

    phase 1 other active

    1 trial

  3. MK-7480 Multiple Ascending Dose Study in Healthy Participants

    Merck Sharp and Dohme

    Non-alcoholic steatohepatitis

    phase 1 other active

    1 trial

  4. MKC-1

    CASI Pharmaceuticals

    Hematological Malignancies

    phase 1 small molecule completed

    1 trial

  5. MLN0128

    Takeda

    Advanced Solid Malignancies

    phase 1 small molecule completed

    2 trials

  6. MLN0264

    Takeda

    Advanced Gastrointestinal Carcinoma

    phase 1 small molecule terminated

    1 trial

  7. MLN0264

    Takeda

    Advanced Gastrointestinal Malignancies

    phase 1 small molecule completed

    1 trial

  8. MLN1117

    Takeda

    Advanced and Metastatic Gastric or Gastroesophageal Adenocarcinoma

    phase 1 small molecule terminated

    1 trial

  9. MLN1202

    Takeda

    Healthy Japanese and Caucasian Male Adults

    phase 1 small molecule terminated

    1 trial

  10. MLN2480

    Takeda

    Melanoma

    phase 1 small molecule completed

    1 trial

  11. MLN2480

    Takeda

    Advanced Nonhematologic Malignancies

    phase 1 small molecule completed

    1 trial

  12. MLN3126

    Takeda

    Safety

    phase 1 small molecule terminated

    1 trial

  13. MLN3126

    Takeda

    Healthy Volunteers

    phase 1 small molecule terminated

    1 trial

  14. MLN4924

    Takeda

    Solid Tumors

    phase 1 small molecule completed

    1 trial

  15. MLN4924

    Takeda

    Advanced Solid Tumors

    phase 1 small molecule completed

    1 trial

  16. MLN4924

    Takeda

    Acute Myelogenous Leukemia

    phase 1 small molecule completed

    1 trial

  17. MLN7243

    Takeda

    Advanced Malignant Solid Tumors

    phase 1 small molecule terminated

    1 trial

  18. MMV390048 40 mg

    CNS Pharmaceuticals

    Malaria

    phase 1 small molecule completed

    1 trial

  19. MNPR-101-DFO*-89Zr

    Monopar Therapeutics

    Solid Tumor, Adult

    phase 1 small molecule active

    1 trial

  20. MNPR-101-PCTA-177Lu

    Monopar Therapeutics

    Solid Tumor, Adult

    phase 1 small molecule active

    1 trial

  21. MOR106

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule terminated

    1 trial

  22. MOR106 single ascending doses, intravenous

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule completed

    1 trial

  23. MP-424 (Telaprevir)

    Vertex Pharmaceuticals (Australia) Pty.

    Chronic Hepatitis C

    phase 1 small molecule completed

    1 trial

  24. MP-424(H), PEG-IFN-a-2b, RBV

    Vertex Pharmaceuticals (Australia) Pty.

    Hepatitis C

    phase 1 small molecule completed

    1 trial

  25. MPT0B640

    INTENSITY THERAPEUTICS, INC.

    Advanced Solid Tumor

    phase 1 small molecule terminated

    1 trial

  26. MPT0B640

    INTENSITY THERAPEUTICS, INC.

    Covid19

    phase 1 small molecule terminated

    1 trial

  27. MRG007

    ArriVent BioPharma

    Locally Advanced or Metastatic Solid Tumors

    phase 1 small molecule active

    1 trial

  28. MRT-6160

    Monte Rosa Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  29. MRT-8102

    Monte Rosa Therapeutics

    Healthy Volunteers

    phase 1 small molecule active

    1 trial

  30. MRx-4DP0004

    4D Molecular Therapeutics

    Asthma

    phase 1 small molecule terminated

    1 trial

  31. MRx0029

    4D Molecular Therapeutics

    Idiopathic Parkinson Disease

    phase 1 mab terminated

    1 trial

  32. MRx0518

    4D Molecular Therapeutics

    Pancreatic Cancer

    phase 1 small molecule terminated

    1 trial

  33. MRx0518 Capsules

    4D Molecular Therapeutics

    Melanoma

    phase 1 small molecule active

    1 trial

  34. MSB11455

    Fresenius Kabi Australia Pty Limited

    Healthy

    phase 1 small molecule completed

    1 trial

  35. MSB11456

    Fresenius Kabi Australia Pty Limited

    Healthy

    phase 1 small molecule completed

    1 trial

  36. MSC-derived exosomes

    Regeneron Ireland Designated Activity Company (DAC)

    Long COVID-19 Syndrome

    phase 1 mab active

    1 trial

  37. MSC2156119J

    Merck KGaA, Darmstadt, Germany

    Solid Tumors

    phase 1 small molecule completed

    1 trial

  38. MSCs

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    COVID-19

    phase 1 mab active

    1 trial

  39. MSCs-derived exosomes

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Coronavirus

    phase 1 mab completed

    1 trial

  40. MSD-001

    Lxo Ireland Designated Activity Company

    Mental Health Disorders

    phase 1 small molecule completed

    1 trial

  41. MT-1186

    Tanabe Pharma

    Healthy Adult Subjects

    phase 1 small molecule completed

    1 trial

  42. MT-401-OTS

    Marker Therapeutics

    Acute Myeloid Leukemia, in Relapse

    phase 1 small molecule active

    1 trial

  43. MT-601

    Marker Therapeutics

    Non-Hodgkin Lymphoma, Adult

    phase 1 small molecule active

    1 trial

  44. MT-601 dose 200 million cells

    Marker Therapeutics

    Pancreas Cancer

    phase 1 small molecule active

    1 trial

  45. MT203 80 mg or matching Placebo

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  46. MTL-CEBPA

    Hospital Authority, Hong Kong

    Advanced Hepatocellular Carcinoma

    phase 1 small molecule active

    1 trial

  47. MTX110

    Biodexa Pharmaceuticals Plc

    Recurrent Glioblastoma

    phase 1 small molecule terminated

    1 trial

  48. MUNC13.4-CD34 suspension, MUNC13.4-T3 suspension

    Pari Pharma GmbH

    Familial Hemophagocytic Lymphohistiocytosis (FHL)

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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