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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

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  1. Losartan potassium 50mg

    United Therapeutics Europe Ltd

    Emotional Processing

    phase 1 small molecule active

    1 trial

  2. Losartan potassium/Hydrochlorothiazide

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  3. Losmapimod 15 mg oral tablet

    Fulcrum Therapeutics

    Healthy Adult Subjects

    phase 1 small molecule completed

    1 trial

  4. Low Density Lipoprotein Receptor mRNA Exosomes

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Familial Hypercholesterolemia

    phase 1 mab active

    1 trial

  5. Low Dose MSH2-/- tumor cell vaccine

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    pMMR/MSS Advanced Colorectal Cancer

    phase 1 mab active

    1 trial

  6. Low Dose REN001

    OnKure Therapeutics

    Fatty Acid Oxidation Disorders

    phase 1 small molecule completed

    1 trial

  7. Low Level Laser Therapy

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Orthodontic Appliance Complication

    phase 1 other completed

    1 trial

  8. Low dose ET019002- T Cells

    The First People's Hospital of Lianyungang

    B-Cell Malignancies

    phase 1 mab active

    1 trial

  9. Low-dose RSV mRNA vaccine

    Sinovac Research and Development Co.,

    RSV

    phase 1 mab active

    1 trial

  10. Lu AF28996

    H. Lundbeck A/S

    Parkinson Disease

    phase 1 small molecule active

    1 trial

  11. Lu AF28996 in Patients With Parkinson's Disease

    H. Lundbeck A/S

    Parkinson's Disease

    phase 1 other active

    1 trial

  12. Lubiprostone

    Takeda

    Chronic Constipation, Methanogenesis

    phase 1 small molecule completed

    1 trial

  13. Lubiprostone

    Takeda

    Other Constipation

    phase 1 small molecule completed

    1 trial

  14. Lucid-21-302

    Quantum Biopharma

    Heathy Participants

    phase 1 small molecule completed

    1 trial

  15. Lucid-21-302

    Quantum Biopharma

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  16. Lumason Contrast-Enhanced Ultrasound

    United Therapeutics Europe Ltd

    Kidney Transplantation

    phase 1 small molecule terminated

    1 trial

  17. Lumason® contrast agent

    United Therapeutics Europe Ltd

    Mitochondrial Myopathies

    phase 1 small molecule active

    1 trial

  18. Lurbinectedin

    Jazz Pharmaceuticals Ireland Limited

    Extensive Stage Lung Small Cell Carcinoma

    phase 1 small molecule active

    1 trial

  19. Lynparza 100 mg film-coated tablets, AZD2281, AZD2281, AZD2281

    AstraZeneca AB

    solid tumors

    phase 1 small molecule active

    1 trial

  20. Lysogenic HSV virus.

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    HNSCC

    phase 1 mab active

    1 trial

  21. M1774 (oral ATR inhibitor) in Combination with PLX038 (Topo1 inhibitor) with dose expansion cohorts in patients with advanced solid tumors

    The George Institute

    Patients with pretreated, metastatic or locally advanced cancer for the dose escalation part and dose expansion cohorts in patients with advanced triple-negative breast cancers and advanced cancers with ATM mutation.

    phase 1 other active

    1 trial

  22. M9466 Alone or in Combination in Advanced Solid Tumors (DDRiver 501)

    Merck Sharp and Dohme

    Advanced solid tumors

    phase 1 other active

    1 trial

  23. M9466 in Combination with Topoisomerase 1 Inhibitors-based Regimens in Advanced Solid Tumors and Colorectal Cancer (DDRiver 511)

    Merck Sharp and Dohme

    Advanced solid tumors and colorectal cancer

    phase 1 other active

    1 trial

  24. MARVEL algorithm

    Rhythm Pharmaceuticals Netherlands B.V.

    Atrioventricular Conduction Block

    phase 1 other completed

    1 trial

  25. MB02-SP

    Mabxience Research SL

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  26. MBG453

    Novartis Pharmaceuticals

    Myelodysplastic Syndromes

    phase 1 small molecule terminated

    1 trial

  27. MBX 1416 (Part A)

    MBX Biosciences

    Postbariatric Hypoglycemia

    phase 1 small molecule completed

    1 trial

  28. MBX 2109

    MBX Biosciences

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  29. MBX 2109 (Part A)

    MBX Biosciences

    Healthy

    phase 1 small molecule completed

    1 trial

  30. MBX 4291

    MBX Biosciences

    Obesity

    phase 1 small molecule active

    1 trial

  31. MC-1-50

    Chongqing Precision Biotech Co., Ltd

    Acute Lymphoblastic Leukemia, in Relapse

    phase 1 mab active

    1 trial

  32. MC-1-50

    Chongqing Precision Biotech Co., Ltd

    Systemic Lupus Erythematosus (SLE)

    phase 1 mab active

    1 trial

  33. MC-1-50

    Chongqing Precision Biotech Co., Ltd

    B Cell Lymphoma

    phase 1 mab active

    1 trial

  34. MCA-derived MSC therapy in renal transplant recipients

    Disc Medicine

    Rejection transplanted kidney, BPAR

    phase 1 other active

    1 trial

  35. MCAM

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Use Disorder

    phase 1 small molecule active

    1 trial

  36. MCI-186

    Tanabe Pharma

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  37. MDGN-002

    Avalo Therapeutics

    Crohn Disease

    phase 1 small molecule terminated

    1 trial

  38. MDMA

    BRIGHT MINDS BIOSCIENCES INC.

    MDMA ('Ecstasy')

    phase 1 small molecule completed

    1 trial

  39. MDMA

    BRIGHT MINDS BIOSCIENCES INC.

    Metabolism

    phase 1 small molecule completed

    1 trial

  40. MEDI1341

    Takeda

    Parkinson's Disease

    phase 1 small molecule completed

    2 trials

  41. METRONIDAZOLE, MOLGRAMOSTIM, Saline Solution Basi 9 mg/ml solution for infusion, FOSFOMYCIN

    Lacuna Pharma Pty Ltd

    peritonitis

    phase 1 small molecule active

    1 trial

  42. MGD020

    United Therapeutics Europe Ltd

    HIV (Human Immunodeficiency Virus)

    phase 1 small molecule active

    1 trial

  43. MGL-3196

    Madrigal Pharmaceuticals EU Limited

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  44. MGL-3196

    Madrigal Pharmaceuticals EU Limited

    Healthy

    phase 1 small molecule completed

    3 trials

  45. MGL-3196 Tablet

    Madrigal Pharmaceuticals EU Limited

    Healthy

    phase 1 small molecule completed

    1 trial

  46. MIRROR; Multispectral and bimodal fluorescent guided surgery (FGS) of high-grade glioma for refining margin assessment: A phase 1 dose finding study using Cetuximab-IRDye800CW- combined with 5-ALA

    Disc Medicine

    Glioblastoma

    phase 1 other active

    1 trial

  47. MK-2420 SAD Study

    Merck Sharp and Dohme

    Rheumatoid arthritis

    phase 1 other active

    1 trial

  48. MK-4318 CIDF Target Engagement Study

    Merck Sharp and Dohme

    Pain

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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