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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 51 of 99

  1. Imatinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Solid Tumor Cancer

    phase 1 small molecule active

    1 trial

  2. Imatinib Mesylate

    Inhibikase Therapeutics

    CML

    phase 1 small molecule completed

    1 trial

  3. Imatinib/Acetaminophen

    Novartis Pharmaceuticals

    Chronic Myeloid Leukemia (CML)

    phase 1 small molecule completed

    1 trial

  4. Impact of CardiolRxTM on Recurrent Pericarditis: An open label Pilot Study

    Cardiol Therapeutics

    Recurrent Pericarditis

    phase 1 other active

    1 trial

  5. Implantation

    Hospital Authority, Hong Kong

    Bone Loss

    phase 1 other active

    1 trial

  6. Improving Peptide Receptor Radionuclide Therapy with PARP inhibitors

    Disc Medicine

    locally advanced or metastatic, well-differentiated gastro-enteropancreatic neuroendocrine tumors.

    phase 1 other active

    1 trial

  7. In situ injection of anti-angiogenics in patients with brain arteriovenous malformations not eligible for exclusion treatment: phase I trial (BLITZ)

    Pari Pharma GmbH

    Cardiology and vascular disease

    phase 1 other active

    1 trial

  8. Inactivated Enterovirus Type 71 Vaccine

    Sinovac Research and Development Co.,

    Infection; Viral, Enterovirus

    phase 1 mab completed

    1 trial

  9. Inactive Marijuana (0% THC)

    BRIGHT MINDS BIOSCIENCES INC.

    Marijuana Use Disorder

    phase 1 small molecule completed

    1 trial

  10. Incentives for being tobacco free

    BRIGHT MINDS BIOSCIENCES INC.

    Tobacco Prevention and Cessation

    phase 1 other completed

    1 trial

  11. Indacaterol (QAB149)

    Novartis Pharmaceuticals

    Healthy

    phase 1 small molecule completed

    1 trial

  12. Individualized caffeine cessation instructions

    BRIGHT MINDS BIOSCIENCES INC.

    Self-identified Problematic Caffeine Use

    phase 1 other completed

    1 trial

  13. Infacort

    NEUROCRINE BIOSCIENCES INC

    Healthy Subjects

    phase 1 small molecule completed

    1 trial

  14. Infigratinib

    BridgeBio Oncology Therapeutics

    Glioma

    phase 1 small molecule terminated

    1 trial

  15. Infigratinib

    BridgeBio Oncology Therapeutics

    Bladder Transitional Cell Carcinoma

    phase 1 small molecule terminated

    1 trial

  16. Infigratinib

    BridgeBio Oncology Therapeutics

    Breast Cancer

    phase 1 small molecule terminated

    1 trial

  17. Influenza A/California/04/09

    United Therapeutics Europe Ltd

    Influenza A

    phase 1 mab active

    1 trial

  18. Influenza A/Texas/71/2017 (H3N2)

    United Therapeutics Europe Ltd

    Influenza Viral Infections

    phase 1 mab completed

    1 trial

  19. Infudopa i.v.

    Lxo Ireland Designated Activity Company

    Parkinson Disease

    phase 1 small molecule completed

    1 trial

  20. Insulin Lispro

    HALOZYME THERAPEUTICS, INC.

    Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  21. Insulin Peglispro

    Eli Lilly and Company

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  22. Insulin aspart

    HALOZYME THERAPEUTICS, INC.

    Type 1 Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  23. Insulin degludec injection, RD15003

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Type 2 Diabetes

    phase 1 mab completed

    1 trial

  24. Intercerebral implantation of allogenic CD34+ stem cell

    Hospital Authority, Hong Kong

    Ischemic Stroke

    phase 1 other active

    1 trial

  25. Interferon beta-1a

    BRIGHT MINDS BIOSCIENCES INC.

    Healthy Subjects

    phase 1 mab completed

    1 trial

  26. Interleukin, NK cells

    Hospital Authority, Hong Kong

    Metastatic Nasopharyngeal

    phase 1 small molecule completed

    1 trial

  27. Interleukin-2

    Iovance Biotherapeutics B.V.

    Chronic Graft Versus Host Disease

    phase 1 small molecule active

    1 trial

  28. Interventional, open-label, single-group, long-term follow-up trial of Lu AG22515 in patients with moderate-to-severe Thyroid Eye Disease

    H. Lundbeck A/S

    Active, moderate-to-severe TED

    phase 1 other active

    1 trial

  29. Intralesional Cemiplimab for Adult Patients with Cutaneous Squamous Cell Carcinoma or Basal Cell Carcinoma

    Lacuna Pharma Pty Ltd

    Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma

    phase 1 other active

    1 trial

  30. Intranasal Oxytocin (IN-OXT)

    Tonix Pharmaceuticals Holding

    Vasopressin Deficiency

    phase 1 small molecule active

    1 trial

  31. Intraparenchymal rAAV1 - (mi)RNA HTT

    Voyager Therapeutics

    Huntington Disease

    phase 1 gene therapy terminated

    1 trial

  32. Intraperitoneal infusion of FAST CEA-targeted CAR-T

    Chongqing Precision Biotech Co., Ltd

    Colorectal Cancer

    phase 1 mab active

    2 trials

  33. Intravenous Artesunate

    United Therapeutics Europe Ltd

    Solid Tumors

    phase 1 small molecule completed

    1 trial

  34. Intravenous Vitamin C

    CNS Pharmaceuticals

    Pancreatic Cancer

    phase 1 small molecule completed

    1 trial

  35. Intravenous stem cell transplantation

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Stroke

    phase 1 gene therapy active

    1 trial

  36. Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants

    Lacuna Pharma Pty Ltd

    Geographic Atrophy

    phase 1 other active

    1 trial

  37. Investigating how CagriSema, semaglutide and cagrilintide regulate insulin effects in the body of people with type 2 diabetes.

    NovoThirteen

    Type 2 diabetes

    phase 1 other active

    1 trial

  38. Investigating how NNC0487-0111 regulates insulin in adults with type 2 diabetes

    NovoThirteen

    Type 2 Diabetes

    phase 1 other active

    1 trial

  39. Investigating the pharmacokinetics of petrelintide using different drug product concentrations in participants with a BMI ≥27.0 kg/m2

    Zealand Pharma A/S

    Weight reduction

    phase 1 other active

    1 trial

  40. Investigation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Injections of NNC0582-0001 in Healthy Adults

    NovoThirteen

    Healthy Volunteers

    phase 1 other active

    1 trial

  41. Investigation of pharmacokinetics, safety and tolerability of a single subcutaneous dose of NNC0487-0111 in participants with various degrees of renal impairment and normal renal function.

    NovoThirteen

    Obesity and Diabetes mellitus Typ 2

    phase 1 other active

    1 trial

  42. Investigational 13-valent Pneumococcal Polysaccharide Conjugate Vaccine

    Sinovac Research and Development Co.,

    Pneumococcal Infections

    phase 1 mab completed

    1 trial

  43. Investigator-Selected Standard PD-1/PD-L1 Inhibitor-Based Therapy

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Solid Tumors

    phase 1 small molecule active

    1 trial

  44. Invivo CAR-T

    Chongqing Precision Biotech Co., Ltd

    B-Acute Lymphoblastic Leukemia

    phase 1 mab active

    1 trial

  45. Ionis AGT-LRx

    IONIS PHARMACEUTICALS INC

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  46. Iopofosine I 131

    Cellectar Biosciences

    Breast Cancer

    phase 1 small molecule active

    1 trial

  47. Ipatasertib

    Hoffmann-La Roche

    Breast Cancer

    phase 1 small molecule terminated

    1 trial

  48. Ipilimumab

    VACCINEX, INC.

    Pathologic Stage IIIB Cutaneous Melanoma AJCC v8

    phase 1 mab active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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