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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 50 of 99

  1. IO-108

    BEONE MEDICINES AUS PTY LTD

    Advanced Solid Tumor

    phase 1 mab completed

    1 trial

  2. IO-202

    BEONE MEDICINES AUS PTY LTD

    Solid Tumor, Adult

    phase 1 mab completed

    1 trial

  3. IO-202

    BEONE MEDICINES AUS PTY LTD

    AML With Monocytic Differentiation

    phase 1 mab completed

    1 trial

  4. ION251

    IONIS PHARMACEUTICALS INC

    Relapsed Multiple Myeloma

    phase 1 small molecule completed

    1 trial

  5. ION269

    IONIS PHARMACEUTICALS INC

    Alzheimer Disease

    phase 1 small molecule terminated

    1 trial

  6. ION356

    IONIS PHARMACEUTICALS INC

    Pelizaeus-Merzbacher Disease

    phase 1 small molecule active

    1 trial

  7. ION464

    IONIS PHARMACEUTICALS INC

    Multiple System Atrophy

    phase 1 small molecule active

    1 trial

  8. ION537

    IONIS PHARMACEUTICALS INC

    Advanced Solid Tumors

    phase 1 small molecule completed

    1 trial

  9. ION547

    IONIS PHARMACEUTICALS INC

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  10. ION904

    IONIS PHARMACEUTICALS INC

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  11. IONIS ANGPTL3-LRx

    IONIS PHARMACEUTICALS INC

    Hypertriglyceridemia

    phase 1 small molecule completed

    1 trial

  12. IONIS FXI-LRx

    IONIS PHARMACEUTICALS INC

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  13. IONIS MAPTRx

    IONIS PHARMACEUTICALS INC

    Mild Alzheimer's Disease

    phase 1 small molecule completed

    1 trial

  14. IONIS TMPRSS6-Lrx

    IONIS PHARMACEUTICALS INC

    Thalassemia

    phase 1 small molecule completed

    1 trial

  15. IONIS-APO(a)-LRx

    IONIS PHARMACEUTICALS INC

    Elevated Lipoprotein(a)

    phase 1 small molecule completed

    1 trial

  16. IONIS-ENaCRx

    IONIS PHARMACEUTICALS INC

    Healthy Subjects

    phase 1 small molecule completed

    1 trial

  17. IOV-2001

    Iovance Biotherapeutics B.V.

    Chronic Lymphocytic Leukemia

    phase 1 mab completed

    1 trial

  18. IP

    Nurix Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  19. IRX4204

    IO Biotech

    Parkinson's Disease

    phase 1 small molecule completed

    1 trial

  20. IRX4204

    IO Biotech

    Lung Cancer, Nonsmall Cell

    phase 1 small molecule terminated

    1 trial

  21. IRX5183

    IO Biotech

    Acute Myeloid Leukemia (AML)

    phase 1 small molecule terminated

    1 trial

  22. ISIS 325568

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  23. ISIS 333611

    IONIS PHARMACEUTICALS INC

    Familial Amyotrophic Lateral Sclerosis

    phase 1 small molecule completed

    1 trial

  24. ISIS 353512

    IONIS PHARMACEUTICALS INC

    Inflammatory Diseases

    phase 1 small molecule completed

    1 trial

  25. ISIS 388626

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  26. ISIS 681257

    IONIS PHARMACEUTICALS INC

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  27. ISU304/CB2679d/Dalcinonacog alfa 75~150 IU/kg

    CATALYST PHARMACEUTICALS, INC.

    Hemophilia B

    phase 1 mab completed

    1 trial

  28. ITI-214 Dose A

    Takeda

    Schizophrenia

    phase 1 small molecule terminated

    1 trial

  29. ITI-333

    BRIGHT MINDS BIOSCIENCES INC.

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  30. ITX 5061

    United Therapeutics Europe Ltd

    Hepatitis C

    phase 1 small molecule completed

    1 trial

  31. IVAC MUTANOME, RBL001/RBL002

    Atrium Therapeutics

    Melanoma

    phase 1 mab completed

    1 trial

  32. IVACFLU

    Repatha

    Influenza

    phase 1 mab completed

    1 trial

  33. IVIb

    CUMBERLAND PHARMACEUTICALS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  34. IW-1701

    Cyclerion Therapeutics

    Healthy

    phase 1 small molecule completed

    2 trials

  35. IW-1973

    Cyclerion Therapeutics

    Healthy

    phase 1 small molecule completed

    2 trials

  36. IW-3300

    IRONWOOD PHARMACEUTICALS INC

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  37. IXAZOMIB

    Takeda

    Advanced Non-hematologic Malignancies

    phase 1 small molecule completed

    1 trial

  38. IXAZOMIB

    Takeda

    Advanced Solid Tumors

    phase 1 small molecule completed

    1 trial

  39. IXP

    Vertex Pharmaceuticals (Australia) Pty.

    Focal Segmental Glomerulosclerosis (FSGS)

    phase 1 small molecule completed

    1 trial

  40. IXP

    Vertex Pharmaceuticals (Australia) Pty.

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  41. Ibudilast 20mg

    BRIGHT MINDS BIOSCIENCES INC.

    Methamphetamine-dependence

    phase 1 small molecule completed

    1 trial

  42. Ibuprofen

    United Therapeutics Europe Ltd

    Tonsillectomy With or Without Adenoidectomy

    phase 1 small molecule terminated

    1 trial

  43. Ibuprofen 800 mg

    United Therapeutics Europe Ltd

    Bone Resorption

    phase 1 small molecule completed

    1 trial

  44. Icatibant (30 mg)

    Takeda

    Hereditary Angioedema (HAE)

    phase 1 small molecule completed

    1 trial

  45. Idefirix 11 mg powder for concentrate for solution for infusion, Delandistrogene moxeparvovec-rokl

    Sarepta Therapeutics

    Duchenne muscular dystrophy (DMD)

    phase 1 small molecule active

    1 trial

  46. Image Guided Dynamic Dosimetry

    United Therapeutics Europe Ltd

    Locally Confined Adenocarcinoma of the Prostate

    phase 1 other completed

    1 trial

  47. Imaging procedure to measure the distribution of a newly developed radiolabeled ligand for the oxytocin receptor

    Tonix Pharmaceuticals Holding

    Pain, Face

    phase 1 small molecule completed

    1 trial

  48. Imatimib Mesylate

    United Therapeutics Europe Ltd

    Lymphangioleiomyomatosis (LAM)

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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