Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs: 4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Fecal Microbiota Transplant (FMT)

MAIA Biotechnology

Chronic Pouchitis

phase 1 small molecule active

1 trial
Fecal Microbiota Transplantation

Finch Therapeutics Group

Enterobacteriaceae Infections

phase 1 mab terminated

1 trial
Fenfluramine

BRIGHT MINDS BIOSCIENCES INC.

Cocaine-Related Disorders

phase 1 small molecule terminated

1 trial
Ferric Carboxymaltose Injection

The First People's Hospital of Lianyungang

Healthy Adult

phase 1 small molecule completed

1 trial
Ferumoxytol

LIPELLA PHARMACEUTICALS INC.

IC - Interstitial Cystitis

phase 1 small molecule completed

1 trial
Fexofenadine

LEXICON PHARMACEUTICALS, INC.

Drug Interactions

phase 1 small molecule completed

1 trial
Fexofenadine 180 mg tablets

Teva Pharma GmbH

Healthy

phase 1 small molecule completed

2 trials
Fexofenadine Hydrochloride without sodium lauryl sulfate

BRIGHT MINDS BIOSCIENCES INC.

The Impact of Excipients on Drug Absorption

phase 1 small molecule completed

1 trial
Filgotinib

Lakefront Biotherapeutics NV

Bioavailability

phase 1 small molecule completed

1 trial
Filgrastim

Rocket Pharmaceuticals B.V.

Fanconi Anemia

phase 1 mab terminated

1 trial
Fimasartan

BRIGHT MINDS BIOSCIENCES INC.

Hypertension

phase 1 small molecule completed

1 trial
Fimasartan

Yung NA

Hypertension

phase 1 small molecule completed

1 trial
Fimasartan

Yung NA

Essential Hypertension

phase 1 small molecule completed

1 trial
Fimasartan/Atorvastatin Combination Tablet

Yung NA

Hypertension

phase 1 small molecule completed

1 trial
Finasteride 5 mg tablets

Teva Pharma GmbH

Healthy

phase 1 small molecule completed

2 trials
Finlepsin 200 retard, 200 mg, tabletki o przedłużonym uwalnianiu, Orungal, 100 mg, kapsułki, Gemfibrozilo STADA 600 mg comprimidos recubiertos con película EFG, Neurotop retard 300, 300 mg, tabletki o przedłużonym uwalnianiu

Minoryx Therapeutics S.L.

Adrenoleukodystrophy

phase 1 small molecule active

1 trial
Firibastat

Quantum Biopharma

Healthy Males

phase 1 small molecule completed

1 trial
First in human pilot study to assess the safety and efficacy of dendritic cells loaded with frameshift derived neopeptides for the prevention of cancer in Lynch Syndrome carriers

The George Institute

Lynch Syndrome

phase 1 other active

1 trial
First in human study of the infusion of ARI0003 cells in relapsed/refractory to treatment B-cell aggressive lymphoma

The George Institute

Relapsed/refractory B-cell aggressive lymphoma

phase 1 other active

1 trial
First in human, Phase 1a/1b Study of KM-023 in healthy volunteers and Olmsted syndrome patients

Lacuna Pharma Pty Ltd

Olmsted syndrome

phase 1 other active

1 trial
First time in human (FTIH) study to investigate the safety and preliminary activity of GSK5533524 alone or in combination in adult participants with advanced solid tumors

GlaxoSmithKline

Neoplasms

phase 1 other active

1 trial
First-In-Human study evaluating the Safety of administration of ABD-3001 to Patients with Relapsed/Refractory Acute Myeloid Leukemia or High/Very-high Risk Myelodysplastic Syndromes

Advanced Accelerator Applications

Patients with Relapsed/Refractory Acute Myeloid Leukemia or High/Very-high Risk Myelodysplastic Syndromes, Ineligible for Intensiveor New Generation Targeted Therapy

phase 1 other active

1 trial
First-in-Human Study of ALN-SNCA in Adult Participants with Early Parkinson’s Disease (PD)

Lacuna Pharma Pty Ltd

Parkinson's disease

phase 1 other active

1 trial
First-in-Human Study of OKI-219 Alone and in Combination with Other Therapies in Patients with Solid Tumors / Breast Cancer

OnKure Therapeutics

Advanced Solid Tumors, Advanced Breast Cancer

phase 1 other active

1 trial
First-in-Human Study of RO7812653

Hoffmann-La Roche

Early Symptomatic Alzheimer’s Disease (eAD), (Mild Cognitive Impairment due to AD, or probable AD dementia)

phase 1 other active

1 trial
First-in-Human Trial of DS3610a in Participants with Advanced Solid Tumors

Daiichi Sankyo

Advanced Solid Tumors

phase 1 other active

1 trial
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants with Atopic Dermatitis

Lacuna Pharma Pty Ltd

Atopic Dermatits

phase 1 other active

1 trial
First-in-Human trial of DS9051b in participants with advanced solid tumors

Daiichi Sankyo

Advanced or Metastatic Adrenocortical Carcinoma (ACC), Metastatic Castration-resistant Prostate Cancer (CRPC)

phase 1 other active

1 trial
First-in-human (FIH) Study of DS-1471a in Subjects with Advanced Solid Tumors

Daiichi Sankyo

Advanced Solid Tumors

phase 1 other active

1 trial
First-in-human (FIH) Trial of GEN3018 in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-risk Myelodysplastic Syndrome (HR-MDS)

Genmab A/S

Relapsed or Refractory Acute Myeloid Leukemia or Higher-Risk Myelodysplastic Syndrome

phase 1 other active

1 trial
First-in-human Phase 1 Study to Assess the Safety, Tolerability, and Immunogenicity of the Adjuvanted Universal Influenza Vaccine “fH1/DSP-0546LP” in Healthy Adults

Lacuna Pharma Pty Ltd

Influenza

phase 1 other active

1 trial
First-in-human Study to Test Safety and Anti-tumor Activity of a Novel Drug for Patients with Advanced Solid Tumor Harboring Genetic Alterations in MET

Turn Therapeutics

Phase 1: Advanced solid tumors harboring genetic alterations in MET

phase 1 other active

1 trial
First-in-human Trial of DS-2243a in Participants with Advanced Solid Tumors

Daiichi Sankyo

Advanced Solid Tumor

phase 1 other active

1 trial
First-in-human study of 225Ac-PSMA-Trillium (BAY 3563254) in participants with advanced metastatic castration-resistant prostate cancer (mCRPC)

Bayer Australia Ltd

Advanced metastatic castration-resistant prostate cancer with prostate specific membrane antigen (PSMA) expression

phase 1 other active

1 trial
First-line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects with Extensive Stage Small Cell Lung Cancer (ES SCLC) (DeLLphi-303)

Amgen

Extensive Stage Small cell lung cancer (ES-SCLC)

phase 1 other active

1 trial
Fixed dose combination Ciprofloxacin/Celecoxib

NeuroSense Therapeutics

ALS (Amyotrophic Lateral Sclerosis)

phase 1 small molecule completed

1 trial
Fluconazole

ENANTA PHARMACEUTICALS INC

NASH - Nonalcoholic Steatohepatitis

phase 1 small molecule completed

1 trial
Fludarabine

Zafatek

Hematologic Malignancies

phase 1 small molecule completed

1 trial
Fluoxetine Hydrochloride

Teva Pharma GmbH

Healthy

phase 1 small molecule completed

2 trials
Fluticasone Propionate MDPI

Teva Pharma GmbH

Asthma

phase 1 small molecule completed

1 trial
Folic Acid 5 MG

The University of Hong Kong

Acute Kidney Injury

phase 1 small molecule active

1 trial
Follicle Stimulating Hormone Receptor T Cells

Anixa Biosciences Inc

Ovarian Cancer

phase 1 small molecule active

1 trial
Food effect and single- and multiple-ascending dose clinical trial of DF2755A in healthy participants

Dompe' Farmaceutici S.p.A.

interstitial cystitis/bladder pain syndrome

phase 1 other active

1 trial
Fospropofol disodium

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Drug Safety

phase 1 small molecule completed

1 trial
Fospropofol disodium

Hospital Authority, Hong Kong

Drug Safety

phase 1 small molecule completed

1 trial
Fostamatinib

RIGEL PHARMACEUTICALS INC

Chronic Graft Versus Host Disease

phase 1 small molecule active

1 trial
Fostamatinib 100 mg bid and Paclitaxel

RIGEL PHARMACEUTICALS INC

Ovarian Cancer

phase 1 small molecule completed

1 trial
Fostamatinib in combination with chemotherapy (gemcitabine and nab-paclitaxel)

RIGEL PHARMACEUTICALS INC

Pancreatic Ductal Adenocarcinoma (PDAC)

phase 1 other active

1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

Quick answer

Top sponsors

Fecal Microbiota Transplant (FMT)

Fecal Microbiota Transplantation

Fenfluramine

Ferric Carboxymaltose Injection

Ferumoxytol

Fexofenadine

Fexofenadine 180 mg tablets

Fexofenadine Hydrochloride without sodium lauryl sulfate

Filgotinib

Filgrastim

Fimasartan

Fimasartan

Fimasartan

Fimasartan/Atorvastatin Combination Tablet

Finasteride 5 mg tablets

Finlepsin 200 retard, 200 mg, tabletki o przedłużonym uwalnianiu, Orungal, 100 mg, kapsułki, Gemfibrozilo STADA 600 mg comprimidos recubiertos con película EFG, Neurotop retard 300, 300 mg, tabletki o przedłużonym uwalnianiu

Firibastat

First in human pilot study to assess the safety and efficacy of dendritic cells loaded with frameshift derived neopeptides for the prevention of cancer in Lynch Syndrome carriers

First in human study of the infusion of ARI0003 cells in relapsed/refractory to treatment B-cell aggressive lymphoma

First in human, Phase 1a/1b Study of KM-023 in healthy volunteers and Olmsted syndrome patients

First time in human (FTIH) study to investigate the safety and preliminary activity of GSK5533524 alone or in combination in adult participants with advanced solid tumors

First-In-Human study evaluating the Safety of administration of ABD-3001 to Patients with Relapsed/Refractory Acute Myeloid Leukemia or High/Very-high Risk Myelodysplastic Syndromes

First-in-Human Study of ALN-SNCA in Adult Participants with Early Parkinson’s Disease (PD)

First-in-Human Study of OKI-219 Alone and in Combination with Other Therapies in Patients with Solid Tumors / Breast Cancer

First-in-Human Study of RO7812653

First-in-Human Trial of DS3610a in Participants with Advanced Solid Tumors

First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants with Atopic Dermatitis

First-in-Human trial of DS9051b in participants with advanced solid tumors

First-in-human (FIH) Study of DS-1471a in Subjects with Advanced Solid Tumors

First-in-human (FIH) Trial of GEN3018 in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-risk Myelodysplastic Syndrome (HR-MDS)

First-in-human Phase 1 Study to Assess the Safety, Tolerability, and Immunogenicity of the Adjuvanted Universal Influenza Vaccine “fH1/DSP-0546LP” in Healthy Adults

First-in-human Study to Test Safety and Anti-tumor Activity of a Novel Drug for Patients with Advanced Solid Tumor Harboring Genetic Alterations in MET

First-in-human Trial of DS-2243a in Participants with Advanced Solid Tumors

First-in-human study of 225Ac-PSMA-Trillium (BAY 3563254) in participants with advanced metastatic castration-resistant prostate cancer (mCRPC)

First-line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects with Extensive Stage Small Cell Lung Cancer (ES SCLC) (DeLLphi-303)

Fixed dose combination Ciprofloxacin/Celecoxib

Fluconazole

Fludarabine

Fluoxetine Hydrochloride

Fluticasone Propionate MDPI

Folic Acid 5 MG

Follicle Stimulating Hormone Receptor T Cells

Food effect and single- and multiple-ascending dose clinical trial of DF2755A in healthy participants

Fospropofol disodium

Fospropofol disodium

Fostamatinib

Fostamatinib 100 mg bid and Paclitaxel

Fostamatinib in combination with chemotherapy (gemcitabine and nab-paclitaxel)

Frequently asked questions

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