Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11661612

    DNA-binding proteins and uses thereof

    Sangamo Therapeutics, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11661617

    Processes for the production of tryptamines

    Compass Pathfinder Limited · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11661601

    Methods for modulating FMR1 expression

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11661599

    CRISPR-Cas based system for targeting single-stranded sequences

    The Regents of the University of California · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11661593

    Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof

    Takeda Pharmaceutical Company Limited · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11661461

    Phospho-Rab antibodies, assays and methods of use thereof

    DENALI THERAPEUTICS INC. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11661459

    Artificial cell death polypeptide for chimeric antigen receptor and uses thereof

    Century Therapeutics, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11661439

    Peptide hydrogels and use thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11661411

    Quinoxaline compounds and uses thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11660571

    Microscale device and method for purification of radiopharmaceuticals

    The Regents of the University of California · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11661426

    Imidazole-containing inhibitors of ALK2 kinase

    BioCryst Pharmaceuticals, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11661401

    2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors

    Revolution Medicines, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11660330

    Combination therapy with semaphorin-4D blockade (SEMA4D) and DC1 therapy

    VACCINEX, INC. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11660325

    Compositions and methods of targeting cancer stem cells

    The Board of Regents of the University of Texas System · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11660318

    Use of adipose tissue-derived stromal stem cells in treating fistula

    Takeda Pharmaceutical Company Limited · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11660277

    Use of (S)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid and related compounds, (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and vigabatrin in the treatment of developmental disorders

    OVID THERAPEUTICS INC. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11660295

    Glucocorticoid receptor modulators to treat cervical cancer

    Corcept Therapeutics Incorporated · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11661455

    Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety

    Orionis Biosciences, Inc · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11660274

    Dosage forms and methods for enantiomerically enriched or pure bupropion

    AXSOME THERAPEUTICS, INC. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11660328

    GLP-2 analogs and peptibodies for administration before, during or after surgery

    Takeda Pharmaceutical Company Limited · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11660352

    Dual function antibodies specific to glycosylated PD-L1 and methods of use thereof

    The Board of Regents of the University of Texas System · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11661611

    Genetic modification of cytokine inducible SH2-containing protein (CISH) gene

    Sangamo Therapeutics, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11660327

    Methods and compositions for oral administration of proteins

    Oramed Ltd. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11661606

    Mature plant transfection using carbon nanotubes

    The Regents of the University of California · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11660335

    Vaccines against coronavirus and methods of use

    Inovio Pharmaceuticals, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11660296

    Treatment of chronic cough, breathlessness and dyspnea

    Trevi Therapeutics, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11661441

    Cell-reactive, long-acting, or targeted compstatin analogs and uses thereof

    Apellis Pharmaceuticals, Inc. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11666596

    Nucleotide, polypeptide and applications thereof

    THE FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11667628

    Compounds for imaging tau proteins that accumulate in brain

    National Institutes for Quantum and Radiological Science and Technology · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11667662

    Modulators of 5′-nucleotidase, ecto and the use thereof

    Arcus Biosciences, Inc. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11670409

    Method and apparatus for providing a pharmacokinetic drug dosing regiment

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11667911

    Use of exonucleases to improve CRISPR/CAS-mediated genome editing

    Editas Medicine, Inc. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11667924

    Increasing levels of nicotinic alkaloids in plants

    22ND CENTURY LIMITED, LLC · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11668704

    Degradation preventing means for immunoassay reagent containing insoluble carrier particles

    Fujikura Kasei Co., Ltd. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11667920

    Methods for treating brain injury

    The Regents of the University of California · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11667784

    Copolymers including cinchona alkaloid components and one or more acrylamide or acrylate containing components, complexes containing the same, and methods of using the

    Regents of the University of Minnesota · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11667717

    Antibodies binding to human IL-4R, preparation method therefor and use thereof

    SUNSHINE GUOJIAN PHARMACEUTICAL (SHANGHAI) CO., LTD. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11666653

    Carbohydrate conjugates as delivery agents for oligonucleotides

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11667701

    Anti-PfRH5 antibodies and antigen-binding fragments thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11667687

    Masked activatable interferon constructs

    CytomX Therapeutics, Inc. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11667683

    Articles comprising a silk polypeptide for antigen delivery

    Ludwig-Maximilians-Universitat Munchen · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11667643

    RIP1K inhibitors

    Rigel Pharmaceuticals, Inc. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11667637

    Fused imidazo-piperidine JAK inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11666671

    Spatial mapping of kidney functions

    Northwestern University · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11667611

    Compositions and methods for inhibition of the JAK pathway

    Rigel Pharmaceuticals, Inc. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11667596

    2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating alpha-synucleinopathies, tauopathies, and other disorders

    PTC THERAPEUTICS, INC. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11666666

    Methods and compositions for modifying a mutant dystrophin gene in a cell's genome

    The Regents of the University of California · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11666658

    Rifamycin analogs and antibody-drug conjugates thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.