Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11628146

    Estrogen receptor ligand treatment for neurodegenerative diseases

    The Regents of the University of California · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11628010

    Selective fat removal using photothermal heating

    The Regents of the University of California · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11629167

    Betulastatin compounds

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11634711

    Methods and compositions for modulating apolipoprotein (a) expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11634691

    Compositions and methods of treatment

    The Regents of the University of California · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11634683

    Non-enzymatic method and milling device

    LIPOREGENA GMBH · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11634507

    Dendritic gold nanoparticles and methods of synthesis

    The Board of Regents of the University of Oklahoma · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11634482

    Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia and cancer

    Julius-Maximilians-Universitat Wurzburg · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11634480

    Human antibodies to GREM1

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11634433

    Macrocycles for use in treating disease

    TURNING POINT THERAPEUTICS, INC. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11634459

    Chimeric reporter West Nile/dengue viruses and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11634447

    Mannose derivatives for treating bacterial infections

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11634424

    Diazaindole derivative and use thereof as CHK1 inhibitor

    Medshine Discovery Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11634404

    Selective D3 dopamine receptor agonists and methods of their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11633511

    Production of immune-response-stimulating aerosols by non-thermal plasma treatment of airborne pathogens

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11633503

    Delivery of oligonucleotide-functionalized nanoparticles

    Northwestern University · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11633501

    Anti-STEAP2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind STEAP2 and CD3, and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11633483

    Modulators of PCSK9 expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11633480

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11633479

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11633496

    Muscle targeting complexes and uses thereof for treating dystrophinopathies

    Dyne Therapeutics, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11633488

    Modified IL-2 polypeptides and uses thereof

    Bright Peak Therapeutics AG · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11633416

    Oral formulations of CD73 compounds

    Arcus Biosciences, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11633405

    Steroid hormone pharmaceutical formulations

    Compass Therapeutics LLC · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11633385

    Combination compositions for treatment of cancer

    RedHill Biopharma Ltd. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11634688

    Methods and compositions for inducing hematopoietic cell differentiation

    Fate Therapeutics, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11634730

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11634540

    Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method

    Nektar Therapeutics · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11634452

    Compounds for treating neurodegenerative disorders

    ETHNODYNE · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11634413

    Neprilysin inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11633471

    Compositions and methods for reducing serum triglycerides

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11634396

    Opioid receptor modulators

    EPIODYNE, INC. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11633498

    Muscle targeting complexes and uses thereof for treating myotonic dystrophy

    Dyne Therapeutics, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11633461

    Enzymes and methods for cleaving n-glycans from glycoproteins

    The Regents of the University of California · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11634418

    Amino acid compounds and methods of use

    Pliant Therapeutics, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11634463

    Methods and compositions for treating hemophilia

    Sangamo Therapeutics, Inc. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11633361

    Soft chew pharmaceutical formulations

    First Time US Generics LLC · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11634443

    Treprostinil prodrugs

    United Therapeutics Corporation · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11633377

    Treatment of circadian rhythm disorders

    VANDA PHARMACEUTICALS INC. · Granted Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 2023130736

    METHODS OF TREATING MIGRAINE

    ALLERGAN PHARMACEUTICALS INT LTD [IE] · Granted Thu Apr 27 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 22 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11638708

    Method of treatment of aggression

    Supernus Pharmaceuticals, Inc. · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11638704

    Bicyclic compounds and their use in the treatment of cancer

    TEMPEST THERAPEUTICS, INC. · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11639347

    Modulators of ATP-binding cassette transporters

    Vertex Pharmaceuticals Incorporated · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11638706

    Methods for treating Huntington's disease

    PTC THERAPEUTICS, INC. · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11638760

    Pyrrolobenzodiazepine antibody conjugates

    Mersana Therapeutics, Inc. · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11638761

    Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy

    Dyne Therapeutics, Inc. · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11639355

    Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors

    Medshine Discovery Inc. · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11640848

    Immunotherapy methods for patients whose tumors carry a high passenger gene mutation burden

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 02 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 27 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.