Monday, July 20, 2026

Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
34

Quick answer

34 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7087591

    21-substituted progesterone derivatives as new antiprogestational agents

    The United States of America, as represented by the Department of Health and Human Services · Granted 2006-08-08T00:00:00.000Z · Expires 2026-08-03T00:00:00.000Z

    granted
  2. US 7122624

    Parathyroid hormone receptor ligands

    The United States of America, as represented by the Department of Health and Human Services · Granted 2006-10-17T00:00:00.000Z · Expires 2026-10-12T00:00:00.000Z

    granted
  3. US 7126008

    Carvedilol

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2006-10-24T00:00:00.000Z · Expires 2026-10-19T00:00:00.000Z

    granted
  4. US 7138137

    Stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2006-11-21T00:00:00.000Z · Expires 2026-11-16T00:00:00.000Z

    granted
  5. US 7148376

    Polymorphic forms of nateglinide

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2006-12-12T00:00:00.000Z · Expires 2026-12-07T00:00:00.000Z

    granted
  6. US 7183272

    Crystal forms of oxcarbazepine and processes for their preparation

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2007-02-27T00:00:00.000Z · Expires 2027-02-22T00:00:00.000Z

    granted
  7. US 7196222

    Sertraline hydrochloride form II and methods for the preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2007-03-27T00:00:00.000Z · Expires 2027-03-22T00:00:00.000Z

    granted
  8. US 7196205

    Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted 2007-03-27T00:00:00.000Z · Expires 2027-03-22T00:00:00.000Z

    granted
  9. US 7199157

    Use of treprostinil to improve kidney functions

    United Therapeutics Corporation · Granted 2007-04-03T00:00:00.000Z · Expires 2027-03-29T00:00:00.000Z

    granted
  10. US 7235691

    Crystalline forms of modafinil

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2007-06-26T00:00:00.000Z · Expires 2027-06-21T00:00:00.000Z

    granted
  11. US 7247751

    Processes for preparing cinacalcet hydrochloride crystal Form I

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2007-07-24T00:00:00.000Z · Expires 2027-07-19T00:00:00.000Z

    granted
  12. US 7256195

    Preparation of risperidone

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2007-08-14T00:00:00.000Z · Expires 2027-08-09T00:00:00.000Z

    granted
  13. US 7262218

    Forms of pravastatin sodium

    TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG · Granted 2007-08-28T00:00:00.000Z · Expires 2027-08-23T00:00:00.000Z

    granted
  14. US 7285668

    Process for the crystallization of (R)- or (S)-lansoprazole

    Takeda Pharmaceutical Company Limited · Granted 2007-10-23T00:00:00.000Z · Expires 2027-10-18T00:00:00.000Z

    granted
  15. US 7288657

    Biphenyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted 2007-10-30T00:00:00.000Z · Expires 2027-10-25T00:00:00.000Z

    granted
  16. US 7300935

    Thienopyrimidine compounds and use thereof

    Takeda Pharmaceutical Company Limited · Granted 2007-11-27T00:00:00.000Z · Expires 2027-11-22T00:00:00.000Z

    granted
  17. US 7319171

    Sertraline hydrochloride form II and methods for the preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-01-15T00:00:00.000Z · Expires 2028-01-10T00:00:00.000Z

    granted
  18. US 7320991

    Analogs of thalidomide as potential angiogenesis inhibitors

    The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · Granted 2008-01-22T00:00:00.000Z · Expires 2028-01-17T00:00:00.000Z

    granted
  19. US 7323459

    Crystal forms, methods for their preparation and method for preparation of olanzapine

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-01-29T00:00:00.000Z · Expires 2028-01-24T00:00:00.000Z

    granted
  20. US 7332472

    Cyclosporine analogue mixtures and their use as immunomodulating agents

    Isotechnika, Inc. · Granted 2008-02-19T00:00:00.000Z · Expires 2028-02-14T00:00:00.000Z

    granted
  21. US 7332612

    Amorphous and crystalline forms of losartan potassium and process for their preparation

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-02-19T00:00:00.000Z · Expires 2028-02-14T00:00:00.000Z

    granted
  22. US 7335799

    Hydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted 2008-02-26T00:00:00.000Z · Expires 2028-02-21T00:00:00.000Z

    granted
  23. US 7348429

    Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted 2008-03-25T00:00:00.000Z · Expires 2028-03-20T00:00:00.000Z

    granted
  24. US 7357945

    Stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-04-15T00:00:00.000Z · Expires 2028-04-10T00:00:00.000Z

    granted
  25. US 7358390

    Polymorphic forms of nateglinide

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-04-15T00:00:00.000Z · Expires 2028-04-10T00:00:00.000Z

    granted
  26. US 7358360

    Risedronate sodium having a very low content of iron

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-04-15T00:00:00.000Z · Expires 2028-04-10T00:00:00.000Z

    granted
  27. US 7358247

    Mycophenolate mofetil impurity

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted 2008-04-15T00:00:00.000Z · Expires 2028-04-10T00:00:00.000Z

    granted
  28. US 7361664

    Vitamin D receptor antagonists and related compositions and methods of use

    The United States of America, as represented by the Department of Health and Human Services · Granted 2008-04-22T00:00:00.000Z · Expires 2028-04-17T00:00:00.000Z

    granted
  29. US 7368468

    Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-05-06T00:00:00.000Z · Expires 2028-05-01T00:00:00.000Z

    granted
  30. US 7368606

    Amorphous cinacalcet hydrochloride and preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-05-06T00:00:00.000Z · Expires 2028-05-01T00:00:00.000Z

    granted
  31. US 7378108

    Percutaneous absorption preparation of compound having angiotensin II antagonistic activity

    Takeda Pharmaceutical Company Limited · Granted 2008-05-27T00:00:00.000Z · Expires 2028-05-22T00:00:00.000Z

    granted
  32. US 7390807

    Crystal forms of lamotrigine and processes for their preparations

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-06-24T00:00:00.000Z · Expires 2028-06-19T00:00:00.000Z

    granted
  33. US 7396542

    Stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-07-08T00:00:00.000Z · Expires 2028-07-03T00:00:00.000Z

    granted
  34. US 7396860

    Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted 2008-07-08T00:00:00.000Z · Expires 2028-07-03T00:00:00.000Z

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.