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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7060466

    Methods of producing hyaluronic acid using a recombinant hyaluronan synthase gene

    The Board of Regents of the University of Oklahoma · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7060672

    Cyclosporin analog formulations

    Isotechnika, Inc. · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7060824

    Pyrrolotriazolopyrimidinone derivatives

    Almirall Prodesfarma S.A. · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7060113

    Hair coloring composition and method

    HairMarker LLC · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7060256

    Increased peroxide content tooth bleaching gel

    DISCUS DENTAL, LLC · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7060259

    Hydrolytically degradable carbamate derivatives of poly(ethylene glycol)

    Nektar Therapeutics AL, Corporation · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7060276

    Plasmodium falciparum AMA-1 protein and uses thereof

    The United States of America as represented by the Secretary of the Army · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7060442

    Modulators on Nod2 signaling

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7060689

    Methods and compositions for delivery and retention of active agents to lymph nodes

    The Board of Regents of the University of Texas System · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7060712

    Crystalline form of aryl aniline β2 adrenergic receptor agonist

    Theravance, Inc. · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7060733

    Methods for treating pancreatitis with curcumin compounds and inhibitors of reactive oxygen species

    The Regents of the University of California · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7060686

    Anti-inflammatory compounds derived from Pseudopterogorgia elisabethae

    The Regents of the University of California · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7060688

    Products and methods for controlling the suppression of the neoplastic phenotype

    The Regents of the University of California · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7060703

    Indolinone derivatives

    Theravance, Inc. · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7060827

    Intermediates useful for making 2,4-pyrimidinediamine compounds

    Rigel Pharmaceuticals, Inc. · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7060837

    Method for the purification of lansoprazole

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7061237

    Remote NMR/MRI detection of laser polarized gases

    The Regents of the University of California · Granted Tue Jun 13 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7063840

    TIE-2 ligands, methods of making and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7064106

    Gene and use thereof

    Takeda Chemical Industries Ltd. · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7063847

    Compositions and methods for enhancing immune responses mediated by antigen-presenting cells

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7064112

    Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist

    CAN-FITE BIOPHARMA LTD. · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7064141

    Method for preventing, treating or inhibiting development of simple retinopathy and preproliferative retinopathy

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7064181

    Physiologically active peptide and its use

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7067109

    Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7067318

    Methods for transfecting T cells

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7067482

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7067527

    Thienopyridine derivatives, their production and use

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7067620

    Antibacterial agents

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7067635

    Nucleotide and deduced amino acid sequences of tumor gene Int6

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7067254

    Diagnosis and treatment of inflammation and hyperactive immune conditions

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7067111

    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7067122

    Modified live Edwardsiella tarda vaccine for aquatic animals

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7067256

    Ribozyme mediated inactivation of the androgen receptor

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7067317

    Regulation of angiogenesis with zinc finger proteins

    Sangamo Biosciences, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7067481

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7067483

    Pharmaceutical compositions containing a gycopeptide antibiotic and a cyclodextrin

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7067537

    Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7067546

    Crystal and process for producing the same

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7067633

    Targeting cellular entry, cell survival, and pathogenicity by dynein light chain 1/PIN in human cells

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7067661

    Pyrazolopyrimidines as cyclin dependent kinase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7067653

    Porphyrin Based neuton capture agents for cancer therapy

    The Regents of the University of California · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7070790

    Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7071293

    Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7070959

    Modified chimeric polypeptides with improved pharmacokinetic properties

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7070607

    Bioabsorbable polymeric implants and a method of using the same to create occlusions

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7070805

    Rapidly disintegrable solid preparation

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7070934

    Ligand-controlled regulation of endogenous gene expression

    Sangamo Biosciences, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7070771

    Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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