Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11673954

    Single-domain antibodies and variants thereof against PD-L1

    Nanjing Legend Biotech Co., Ltd · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 11673953

    DLL3 targeting chimeric antigen receptors and binding agents

    Allogene Therapeutics, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 11673902

    Isoindolinone and indazole compounds for the degradation of EGFR

    C4 THERAPEUTICS, INC. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 11673887

    N-acyl amino acid compounds and methods of use

    Pliant Therapeutics, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 11673899

    Crystal form of thieno[2,3-c]pyridazine-4(1H)-one compound, preparation method therefor and use thereof

    Medshine Discovery Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 11673898

    Substituted inhibitors of menin-MLL and methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 11673896

    Pyridine compounds as allosteric SHP2 inhibitors

    Revolution Medicines, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 11673866

    Estrogen receptor beta ligands for the prevention and treatment of multiple sclerosis (MS) and other demyelinating, inflammatory and neurodegenerative diseases

    The Regents of the University of California · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 11673860

    Crystalline siponimod fumaric acid and polymorphs thereof

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 11673864

    Pyridone amides as modulators of sodium channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 11673867

    Sulfonamide derivative or pharmaceutically acceptable acid-addition salt

    The Board of Regents of the University of Texas System · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 11673873

    Apelin receptor agonists and methods of use thereof

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 11672871

    Peptide oligonucleotide conjugates

    Sarepta Therapeutics, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 11672863

    Enhanced solubility drug-containing formulations

    United Therapeutics Corporation · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 11672832

    Development of amnion-like tissue from human pluripotent stem cells

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 11672811

    Materials and methods for suppressing and/or treating bone related diseases and symptoms

    The United States of America as Represented by the Department of Veteranas Affairs · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 11672794

    Therapeutic targeting of the BAP1 complex in cancer

    Northwestern University · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 11672793

    Compositions of CXCR4 inhibitors and methods of preparation and use

    X4 Pharmaceuticals, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 11672791

    Tyrosine kinase inhibitors

    Rigel Pharmaceuticals, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 11672775

    Treprostinil prodrugs

    United Therapeutics Corporation · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 11672776

    Multi-arm polymeric alkanoate conjugates

    Nektar Therapeutics · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 11672762

    Onapristone extended-release compositions and methods

    CONTEXT BIOPHARMA, INC. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 11679158

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. KR 20230088753

    파킨슨병 치료를 위한 오피카폰 및 레보도파

    BIAL PORTELA & CA SA [PT] · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 11679151

    Stabilized influenza hemagglutinin stem region trimers and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 11679157

    Controlled release mucoadhesive systems

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 11680105

    Antibody fragments for detecting cancer and methods of use

    Regents of the University of Minnesota · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 11679121

    Morpholino oligonucleotides useful in cancer treatment

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 11679130

    Genetically engineered t cells with Regnase-1 and/or TGFBRII disruption have improved functionality and persistence

    CRISPR THERAPEUTICS AG · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 11679075

    Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 11680062

    3,4-methylenedioxyphenylimidazolylethanonexime ether derivative, preparation method and use thereof, and drug for the treatment of Alzheimer's disease

    Northwest A & F University · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 11679101

    Anhydrous compositions of mTOR inhibitors and methods of use

    PALVELLA THERAPEUTICS, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 11679100

    Methods of enhancing immunity

    The Regents of the University of California · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 11679150

    Mycoplasma bovis vaccine product

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 11680254

    Engineered meganucleases specific for recognition sequences in the PCSK9 gene

    Precision BioSciences, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 11680249

    Adeno-associated virus capsid variants and methods of use thereof

    The Regents of the University of California · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 11680244

    Method for generating human dendritic cells for immunotherapy

    The Regents of the University of California · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 11680079

    Nucleic acid aptamers to treat histone-induced disease states

    The United States Government as Represented by The Department of Veteran Affairs · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 11680093

    Monoclonal antibodies that specifically bind to matrilin 3 and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 11680090

    Interleukin-2 fusion proteins and uses thereof

    Medicenna Therapeutics Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 11680070

    Thieno[2,3-c]pyridazin-4(1H)-one derivative and application thereof

    Medshine Discovery Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 11680067

    Small molecules for the treatment of primary cancer and cancer metastasis

    The Board of Regents of the University of Texas System · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 11680036

    Methods for making and using endoxifen

    ATOSSA THERAPEUTICS, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 11680034

    Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

    PTC THERAPEUTICS, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 11679161

    Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy

    Dyne Therapeutics, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 11679159

    Compositions for transfecting resistant cell types

    Precision Nanosystems ULC · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 11679143

    FGF21 variant, fusion protein and application thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 11679131

    Genetically engineered T cells with regnase-1 and/or TGFBRII disruption have improved functionality and persistence

    CRISPR THERAPEUTICS AG · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.