Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2040

Annual patent cliff calendar for 2040 — US pharmaceutical patents by expiration date.

Patents
1,866

Quick answer

1,866 indexed pharmaceutical patents have expiration dates in 2040. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10668050

    Compositions, methods and kits for treating diarrhea-predominant irritable bowel syndrome

    RedHill Biopharma Ltd. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 10668114

    Use of gram negative species to treat atopic dermatitis

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 10668170

    Modified RNAi agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 10669242

    Clostridium difficile toxin inhibitors

    VENENUM BIODESIGN, LLC · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 10668279

    Miniminally invasive dermal electroporation device

    Inovio Pharmaceuticals, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 10669303

    Compositions and methods directed to treating liver fibrosis

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 10668118

    Microbial consortium and uses thereof

    The Regents of the University of California · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 10668260

    Microneedle patch

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 10669320

    Mps1 and KNL1 phosphorylation system

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 10669311

    Targeted delivery system and methods of use therefor

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 10669544

    Therapeutic compositions

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 10669337

    Bispecific anti-CD3 antibodies, bispecific activatable anti-CD3 antibodies, and methods of using the same

    CytomX Therapeutics, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 10668171

    Methods for modulating RNA splicing

    PTC THERAPEUTICS, INC. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 10669312

    Peptide for suppressing osteoclast differentiation and use thereof

    CAREGEN CO., LTD. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 10669560

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 10668127

    Method and composition for synchronizing time of insemination

    United-AH II, LLC · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 10669347

    Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use

    Sutro Biopharma, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 10669298

    Mannose derivatives for treating bacterial infections

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 10668129

    Synergistic combination of neuronal viability factors and uses thereof

    The Regents of the University of California · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 10668107

    Methods of transdifferentiation and methods of use thereof

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 10668049

    Methods of treating cognitive decline with transforming growth factor beta inhibitors

    The Regents of the University of California · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 10668015

    Unit aerosol doses for anticoagulation

    The Regents of the University of California · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 10668002

    Anhydrous polysaccharide films

    ReGenesis Group · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 10668055

    Cancer treatment using combinations of ERK and RAF inhibitors

    Biomed Valley Discoveries, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 10668062

    Oxabicycloheptanes and oxabicycloheptenes for the treatment of diabetes

    Lixte Biotechnology, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 10668161

    Therapeutic hyperbranched polyglycerol encapsulated biomolecules

    The Regents of the University of California · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 10669339

    Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof

    CytomX Therapeutics, Inc. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 10667994

    Bioactive dental restorative material with remineralization properties

    The Regents of the University of California · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 10668021

    Metformin hydrochloride osmotic pump tablet and preparation method therefor

    ELITE PHARMA TECHNOLOGY (SHANGHAI) CO., LTD. · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 10669516

    Methods and apparatus for conditioning cell populations for cell therapies

    The Board of Regents of the University of Texas System · Granted Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. CA 3121191

    CAS9 DE CODAGE D'ARNM OPTIMISE DESTINE A ETRE UTILISE DANS DES LNP

    CRISPR THERAPEUTICS AG [CH] · Granted Thu Jun 04 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 30 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 10675308

    Chinese medicine extract and preparation method and application thereof

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 10675246

    Orally administrable compositions comprising calcium

    CEROLIFE LLC · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 10675245

    Sustained release formulation of a non-steroidal anti-inflammatory drug

    Pacira Pharmaceuticals, Inc. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 10676530

    Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an antibody to IL-4 receptor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 10675358

    Antibody adjuvant conjugates

    Bolt Biotherapeutics, Inc. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 10676474

    1,6-naphthyridine derivatives as CDK4/6 inhibitor

    Medshine Discovery Inc. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 10675341

    Parenteral norovirus vaccine formulations

    Takeda Vaccines, Inc. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 10675304

    Combination immunotherapies for treatment of cancer

    PrimeVax Immuno-Oncology · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 10675288

    Natural combination hormone replacement formulations and therapies

    Compass Therapeutics LLC · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 10675258

    Method of using gamma-hydroxybutyrate compositions for the treatment of disorders

    Jazz Pharmaceuticals Ireland Limited · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 10675272

    Compositions for an orally active 1,2,4-oxadiazole for the treatment of disease

    PTC THERAPEUTICS, INC. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 10674901

    Minimally-invasive measurement of esophageal inflammation

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 10675273

    Benzothiazole amphiphiles

    The Regents of the University of California · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 10675271

    Clonidine and/or clonidine derivatives for use in the prevention and/or treatment of adverse side effects of chemotherapy

    Monopar Therapeutics Inc. · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 10675283

    Compositions and methods for white to beige adipogenesis

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 10677801

    Diagnosis and treatment of breast cancer

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 10675267

    Methods for detection and eradication of myeloid leukemia stem cells

    The Regents of the University of California · Granted Tue Jun 09 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2040?

1,866 published patents in our USPTO index have expiration dates falling in calendar year 2040.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.