Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8445044

    Food thickening agent, method for producing food thickening agent

    Kent Precision Foods Group, Inc. · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8445665

    Therapeutic compositions

    Alnylam Pharmaceuticals, Inc. · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8445254

    Regulated expression of antigen and/or regulated attentuation to enhance vaccine immunogenicity and/or safety

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8445245

    Mutant MT-SP1 proteases with altered substrate specificity or activity

    Catalyst Biosciences, Inc. · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8445473

    Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8445501

    Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines

    TAKEDA GMBH · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8445541

    Methods for concomitant administration of colchicine and a second active agent

    Takeda Pharmaceuticals U.S.A., Inc. · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8444996

    Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8445507

    Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases

    The Regents of the University of California · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8445696

    Synthetic methods for spiro-oxindole compounds

    Xenon Pharmaceuticals Inc. · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8445632

    Selective poly-N-substituted glycine antibiotics

    The Regents of the University of California · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8445658

    Proteins with repetitive bacterial-Ig-like (Big) domains present in Leptospira species

    THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8445694

    Hydrazonopyrazole derivatives and their use as therapeutics

    Dermira (Canada), Inc. · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8445681

    Azaindazoles useful as inhibitors of kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8445509

    Fused heterocyclic derivatives and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8445445

    Method of promoting hair growth using FGFR4 extracellular domains

    Five Prime Therapeutics, Inc. · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8445216

    Antibodies and immunotoxins that target human glycoprotein NMB

    The United States of America as Represented by the Secretary of Health and Human Services, National Institutes of Health · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8444991

    Method of preparing an immunologically-active adjuvant-bound dried vaccine composition

    The Regents of the University of Colorado, a Body Corporate · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8445021

    Functionalized magnetic nanoparticles and methods of use thereof

    The Regents of the University of California · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8445588

    Hydrophilic copolymers and assemblies containing the same

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 21 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 16 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8450285

    Immunoregulatory peptides and methods of use

    Compass Therapeutics LLC · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8449872

    Polymer conjugates of nesiritide peptides

    Nektar Therapeutics · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8449875

    Targeting pseudotyped retroviral vectors

    The Regents of the University of California · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8450481

    Compounds for inhibiting protein aggregation, and methods for making and using them

    The Regents of the University of California · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8449884

    Clotting factor-fc chimeric proteins to treat hemophilia

    Syntonix Pharmaceuticals, Inc. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8449909

    Abuse-deterrent drug formulations

    Collegium Pharmaceutical, Inc. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8450337

    Methods of treating skin disorders with caffeic acid analogs

    Moleculin, LLC · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8449876

    Human lysosomal proteins from plant cell culture

    Protalix Ltd. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8450325

    Methods for reducing the recurrence of cardiac arrhythmia

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8450323

    Substituted derivatives of pyrido[3,2-e][1,4]thiazino[4,3-a]pyrazine and pyrido[3,2-e][1,4]oxazino[4,3-a]pyrazine

    Takeda Pharmaceutical Company Limited · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8450062

    SOCS-3 promoter methylation in cancer

    The Regents of the University of California · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8450299

    Methods of hormonal treatment utilizing ascending-dose extended cycle regimens

    Teva Womans's Health, Inc. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8449911

    Drug composition having active ingredient adhered at high concentration to spherical core

    Takeda Pharmaceutical Company Limited · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8450278

    MUC18 targeting peptides

    The Board of Regents of the University of Texas System · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8450339

    Compositions for treatment of common cold

    Takeda Pharma A/S · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8450341

    Substituted indolin-2-one derivatives and their use as P38 mitogen-activated kinase inhibitors

    Almirall, S.A. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8450489

    Azaindoles useful as inhibitors of janus kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8450358

    Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents

    Xenon Pharmaceuticals Inc. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8450332

    LIMK2 inhibitors, compositions comprising them, and methods of their use

    LEXICON PHARMACEUTICALS, INC. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8450321

    6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor

    GILEAD CONNECTICUT, INC. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8450055

    Malaria antigen screening method

    United States of America as represented by the Secretary of the Air Force · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8449890

    Neprilysin inhibitors

    Theravance, Inc. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8449877

    Pharmaceutically purified intact bacterial minicells

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8450271

    Peptide-based scaffolds for cartilage regeneration and methods for their use

    Northwestern University · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8450070

    Method for screening of cell-protecting agent

    Takeda Pharmaceutical Company Limited · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8450345

    Iminosugars and methods of treating viral diseases

    United Therapeutics Corporation · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8450379

    Methods for treating migraine

    Corcept Therapeutics Incorporated · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8450362

    Amidine-containing compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue May 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.