Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8350027

    Dual-acting pyrazole antihypertensive agents

    Theravance, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8349333

    Allergy inhibitor compositions and kits and methods of using the same

    China Agricultural University · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8349353

    Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders

    The Regents of the University of California · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8349892

    Solid formulations of prostacyclin analogs

    United Therapeutics Corporation · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8349308

    Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof

    Mersana Therapeutics, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8348921

    Gels with predetermined conductivity used in electroporation of tissue

    The Regents of the University of California · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8349568

    Method of diagnosing poor survival prognosis colon cancer using let-7g

    The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8349899

    Selective inhibitors of EG5 motors and methods of use

    Arrowhead Center, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8349875

    Dual-acting antihypertensive agents

    Theravance, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8349609

    Differentiation of human embryonic and induced pluripotent stem cells

    UNIVERSITY OF CONNECTICUT · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8349910

    Aldehyde tags, uses thereof in site-specific protein modification

    The Regents of the University of California · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8349810

    Methods for targeted cleavage and recombination of CCR5

    Sangamo Biosciences, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8349586

    Commensal strain of E. coli encoding an HIV GP41 protein

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8350021

    Conserved HBV and HCV sequences useful for gene silencing

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8349888

    Phytoestrogenic isoflavone compositions, their preparation and use thereof for protection against and treatment of radiation injury

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8349848

    Pyrrolo[3,2-D]pyrimidines that are selective antagonists of A2B adenosine receptors

    Dogwood Pharmaceuticals, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8349800

    Von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage

    Nektar Therapeutics · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8349894

    Compositions comprising an o/w emulsion containing conjugated linoleic acid

    Aker Biomarine AS · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8350065

    5,6-dimethyl xanthone-4-acetic acid derivatives and method of preparing the same

    GRANDPHARMA (CHINA) CO., LTD. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8349886

    Nitrogenated 5-membered heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8350077

    Amides of creatine, method of their preparation, and remedy possessing a neuroprotective activity

    Vertex Closed Joint Stock Company · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8349987

    Adhesive formulations

    Covidien LP · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8350079

    Treprostinil formulation

    United Therapeutics Corporation · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8349307

    Polymer conjugates of opioid antagonists

    Nektar Therapeutics · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8349312

    Proline substituted cyclosporin analogues

    Enanta Pharmaceuticals, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8349391

    Radium target and method for producing it

    Actinium Phamaceuticals, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8350042

    Antiviral compounds for the treatment of HCV infection

    The Regents of the University of California · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8349371

    Method for anti-oxidation, inhibiting activity and/or expression of matrix metalloproteinase, and/or inhibiting phosphorylation of mitogen-activated protein kinase using neonauclea reticulata leaf extracts

    China Medical University · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8350126

    Green garlic and methods of production

    Ophios, LLC · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8349838

    Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors

    Rigel Pharmaceuticals, Inc. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8349879

    Tricyclic compound and pharmaceutical use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8349355

    Formulations of lipoic acid and hyaluroinc acid and/or the derivatives thereof in the pharmaceutical and cosmetic fields

    Anika Therapeutics S.r.l. · Granted Tue Jan 08 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. AU 2011260615

    Oral dosage forms of bendamustine

    ASTELLAS DEUTSCHLAND GMBH [CH] · Granted Thu Jan 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jan 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. AU 2011260614

    Oral dosage forms of bendamustine and therapeutic use thereof

    ASTELLAS DEUTSCHLAND GMBH [CH] · Granted Thu Jan 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jan 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8354383

    6,11-bridged biaryl macrolides

    Enanta Pharmaceuticals, Inc. · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8354103

    Human antibodies to human angiopoietin-like protein 4

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8354549

    Method for preparing a polymer conjugate

    Nektar Therapeutics · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8354115

    CD40 ligand adjuvant for respiratory syncytial virus

    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8354538

    Small-molecule inhibitors of the androgen receptor

    The Regents of the University of California · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8354436

    IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation

    4SC DISCOVERY GMBH · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8354240

    VMP-like sequences of pathogenic Borrelia

    The Board of Regents of the University of Texas System · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8354446

    Selective androgen receptor modulators (SARMs) and uses thereof

    Ligand Pharmaceuticals Incorporated · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8354450

    Creatine oral supplementation using creatine hydrochloride salt

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8354419

    Benzimidazole analogues for the treatment or prevention of flavivirus infections

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8354390

    Compositions and methods for inhibiting expression of a gene from the ebola virus

    The United States of America as represented by the Secretary of the Army · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8354427

    Modulators of ATP-binding cassette transporters

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8354477

    Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules

    Nektar Therapeutics · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8354411

    1-phenyl-3-pyrazolylpyridazin-4(1H)-one compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 15 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.