Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8461298

    Compositions and methods for modification of biomolecules

    The Regents of the University of California · Granted Tue Jun 11 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8460693

    Intraluminal device with a coating containing synthetic fish oil and a therapeutic agent

    ATRIUM MEDICAL CORPORATION · Granted Tue Jun 11 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8461339

    Pharmaceutical compounds

    SENTINEL ONCOLOGY LIMITED · Granted Tue Jun 11 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8460651

    Methods of treating amyotrophic lateral sclerosis (ALS)

    The Regents of the University of California · Granted Tue Jun 11 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8460643

    Formulation for prophylaxis of oral cavity diseases

    OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU “WELDUP” · Granted Tue Jun 11 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8460713

    Administration of cells and cellular extracts for rejuvenation

    REGENICS AS · Granted Tue Jun 11 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8466288

    Isoindolinone inhibitors of phosphatidylinositol 3-kinase

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8465767

    Oral administration form for pyridin-2-ylmethylsulfinyl-1H benzimidazoles

    TAKEDA GMBH · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8465917

    Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells

    The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8465737

    Three-dimensional structure of complement receptor type 2 and uses thereof

    The Regents of the University of Colorado · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8466290

    STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient

    Pharmadesign, Inc. · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8465746

    Compositions and methods for treatment, research and therapeutic applications for malaria

    Northwestern University · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8465743

    Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8466282

    Heterocyclic compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8466267

    Nucleic acid encoding a zinc finger that recognizes the sodium channel Nav 1.8 (PN3) gene

    Sangamo Biosciences, Inc. · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8466276

    Oligomer conjugates of heteropentacyclic nucleosides

    Nektar Therapeutics · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8465755

    Recombinant bacterium capable of eliciting an immune response against enteric pathogens

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8466188

    Use of spiro-oxindole compounds as therapeutic agents

    Xenon Pharmaceuticals Inc. · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8466154

    Methods and compositions related to wrapping of dehydrons

    The Board of Regents of the University of Texas System · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8465749

    Polysaccharide-protein conjugate vaccines

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jun 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. WO 2013088335

    FORME CRISTALLINE DE CABAZITAXEL ET PROCÉDÉ POUR PRÉPARER CELLE-CI

    AVENTIS PHARMA SA [FR] · Granted Thu Jun 20 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 15 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8470789

    Method for inducing and accelerating cells

    DCPRIME B.V. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8470837

    MAPK/ERK kinase inhibitors

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8470326

    Monoclonal antibody therapy for pancreas cancer

    PRECISION BIOLOGICS, INC. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8471014

    Process of making gyrase and topoisomerase IV inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8471040

    Serotonin reuptake inhibitors

    Theravance, Inc. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8470528

    Methods and compositions related to adenoassociated virus-phage particles

    The Board of Regents of the University of Texas System · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8470364

    Once daily formulations of tetracyclines

    Supernus Pharmaceuticals, Inc. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8470545

    Methods of modulating cold sensory perception via a cold- and menthol-sensitive receptor (CMR1)

    The Regents of the University of California · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8470301

    Particulate materials

    Nektar Therapeutics · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8470988

    Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8471029

    Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8470976

    Methods and compositions for targeting macromolecules into the nucleus

    The Board of Regents of the University of Texas System · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8470888

    Botryllamides and method of inhibiting PGP in a mammal afflicted with cancer

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8470872

    Compounds with activity at estrogen receptors

    ACADIA Pharmaceuticals Inc. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8470859

    Iminopyridine derivative and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8470816

    Nitrogen-containing heterocyclic compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8470799

    Compositions and methods for inhibiting expression of the HAMP gene

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8470344

    Aqueous dispersions and solutions of difficult to dissolve materials and methods of their preparation

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8470520

    Decellularization and recellularization of organs and tissues

    Regents of the University of Minnesota · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8470342

    Methods of altering an immune response induced by CpG oligodeoxynucleotides

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8470324

    Fusion polypeptides capable of activating receptors

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8470312

    Abrogating proinflammatory cytokine production during oncolytic reovirus therapy

    ONCOLYTICS BIOTECH INC. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8469899

    Management of gastro-intestinal disorders

    EXALENZ BIOSCIENCE LTD. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8470296

    Intracorporeal medicaments for high energy phototherapeutic treatment of disease

    Provectus Pharmatech, Inc. · Granted Tue Jun 25 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. CA 2858984

    UTILISATION D'UN C1-INHIBITEUR DESTINE AU TRAITEMENT D'UN OEDEME SECONDAIRE DU SYSTEME NERVEUX CENTRAL

    CSL BEHRING GMBH [DE] · Granted Thu Jun 27 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 22 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8475792

    Molecules with extended half-lives, compositions and uses thereof

    Board of Regents, The Texas University System · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8476229

    Blood sugar-modulating polypeptides

    China Medical University · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.