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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. olaparib

    United Therapeutics Europe Ltd

    Advanced Cancer

    phase 1 small molecule completed

    1 trial

  2. omacetaxine mepesuccinate

    Teva Pharma GmbH

    Hematologic Malignancies

    phase 1 small molecule completed

    1 trial

  3. ombrabulin (AVE8062)

    Sanofi Pasteur

    Neoplasms, Malignant

    phase 1 small molecule completed

    1 trial

  4. oncolytic virus (OVV-01) injection

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Neoplasms

    phase 1 small molecule active

    1 trial

  5. oral naltrexone

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Dependence

    phase 1 small molecule completed

    1 trial

  6. oral palifosfamide tris

    Alaunos Therapeutics

    Advanced Cancer

    phase 1 small molecule on hold

    1 trial

  7. oral treprostinil

    United Therapeutics Europe Ltd

    Raynaud's Phenomenon

    phase 1 small molecule completed

    1 trial

  8. oxytocin

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Healthy

    phase 1 small molecule active

    6 trials

  9. pCAR-19B cells

    Chongqing Precision Biotech Co., Ltd

    Acute Lymphoblastic Leukemia, in Relapse

    phase 1 mab active

    1 trial

  10. pTVG-HP with rhGM-CSF

    United Therapeutics Europe Ltd

    Prostate Cancer

    phase 1 mab completed

    1 trial

  11. paclitaxel cationic liposome for injection

    CSPC Baike (Shandong) Biopharmaceutical Co.,

    Colorectal Liver Metastases

    phase 1 small molecule active

    1 trial

  12. palifosfamide-tris

    Alaunos Therapeutics

    Malignancy

    phase 1 small molecule active

    1 trial

  13. palifosfamide-tris

    Alaunos Therapeutics

    Advanced Solid Tumors

    phase 1 small molecule active

    1 trial

  14. pandemic influenza vaccine (H5N1 strain NIBRG-14)

    Sinovac Research and Development Co.,

    Pandemic Influenza Vaccine

    phase 1 mab completed

    1 trial

  15. patisiran

    Alnylam Netherlands B.V.

    Polyneuropathies

    phase 1 small molecule completed

    1 trial

  16. patisiran (ALN-TTR02)

    Alnylam Netherlands B.V.

    Transthyretin (TTR)-Mediated Amyloidosis

    phase 1 small molecule completed

    1 trial

  17. pd-1 and DC-NK cells

    The First People's Hospital of Lianyungang

    Solid Tumor

    phase 1 small molecule active

    1 trial

  18. pd-1 and dc-cik cells

    The First People's Hospital of Lianyungang

    Solid Tumor

    phase 1 small molecule active

    1 trial

  19. peficitinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  20. placebo

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule completed

    1 trial

  21. placebo

    Innovent Biologics (Suzhou) Co.

    Healthy

    phase 1 mab completed

    1 trial

  22. placebo control

    Takeda

    Hemophilia

    phase 1 small molecule terminated

    1 trial

  23. pomalidomide

    Celgene Europe Limited

    Multiple Myeloma in Relapse

    phase 1 small molecule completed

    1 trial

  24. pravastatin

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  25. pravastatin sodium

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  26. prophylactic 4SCAR19 cells

    The First People's Hospital of Lianyungang

    B Acute Lymphoblastic Leukemia

    phase 1 gene therapy active

    1 trial

  27. pyroglutamate rongliflozin capsules

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Type 2 Diabetes

    phase 1 small molecule completed

    1 trial

  28. pyroglutamate rongliflozin capsules

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Diabetes Mellitus, Type 2

    phase 1 small molecule completed

    1 trial

  29. questionnaires

    Cardiff Oncology

    Anxiety

    phase 1 other active

    1 trial

  30. quitSTART Mobile Application

    BRIGHT MINDS BIOSCIENCES INC.

    Nicotine Vaping

    phase 1 other active

    1 trial

  31. rAAVrh74.MHCK7.DYSF.DV

    Sarepta Therapeutics

    Dysferlinopathy

    phase 1 small molecule completed

    1 trial

  32. rHuPH20

    HALOZYME THERAPEUTICS, INC.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  33. rHuPH20

    HALOZYME THERAPEUTICS, INC.

    Risk Factors for or a Diagnosis of Osteoporosis

    phase 1 small molecule completed

    1 trial

  34. rQNestin

    Candel Therapeutics

    Malignant Glioma of Brain

    phase 1 small molecule active

    1 trial

  35. rSIFN-co

    Sichuan Provincial People's Hospital

    Carcinoma, Non-Small-Cell Lung

    phase 1 small molecule completed

    1 trial

  36. radioactive substance

    BRIGHT MINDS BIOSCIENCES INC.

    Amphetamine-Related Disorders

    phase 1 other active

    1 trial

  37. randomized, double-blinded, placebo-controlled

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Prevention of COVID-19 Caused by SARS-CoV-2

    phase 1 mab active

    1 trial

  38. recombinant adenovirus containing the ornithine transcarbamylase gene

    Ultragenyx UK Limited

    Ornithine Transcarbamylase Deficiency Disease

    phase 1 gene therapy terminated

    1 trial

  39. recombinant human thrombopoietin injection

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Liver Disease Chronic

    phase 1 small molecule active

    1 trial

  40. removal of omentum

    United Therapeutics Europe Ltd

    Diabetes Mellitus Type 2

    phase 1 other completed

    1 trial

  41. rhASA - Dose Level 1

    Takeda

    Metachromatic Leukodystrophy (MLD)

    phase 1 mab completed

    1 trial

  42. rhPTH(1-84)

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  43. riliprubart

    Vera Therapeutics

    Autoimmune haemolytic anaemia

    phase 1 small molecule active

    1 trial

  44. rilonacept (IL-1 Trap)

    Regeneron UK Limited

    Systemic Juvenile Idiopathic Arthritis

    phase 1 small molecule completed

    1 trial

  45. routine HIV testing

    BRIGHT MINDS BIOSCIENCES INC.

    HIV Infections

    phase 1 other completed

    1 trial

  46. sD-NP-GT8 DNA

    INOVIO PHARMACEUTICALS, INC.

    HIV Infections

    phase 1 mab completed

    1 trial

  47. sabirnetug (ACU193)

    Acumen Pharmaceuticals

    Alzheimer Disease

    phase 1 small molecule completed

    1 trial

  48. salvianolic acid A

    The First People's Hospital of Lianyungang

    Healthy

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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