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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. administration of UI058

    United Therapeutics Europe Ltd

    GERD

    phase 1 small molecule completed

    1 trial

  2. administration of UI068

    United Therapeutics Europe Ltd

    Diabetes Mellitus, Type 2

    phase 1 small molecule completed

    1 trial

  3. aerosol inhaled amikacin

    The First People's Hospital of Lianyungang

    Chronic Obstructive Pulmonary Disease (COPD)

    phase 1 small molecule completed

    1 trial

  4. aflibercept

    Regeneron UK Limited

    Lymphoma, Non-Hodgkin

    phase 1 small molecule completed

    1 trial

  5. aflibercept (AVE0005)

    Regeneron UK Limited

    Cancer

    phase 1 small molecule completed

    1 trial

  6. aflibercept (AVE0005)

    Regeneron UK Limited

    Neoplasms

    phase 1 small molecule completed

    2 trials

  7. agenT-797

    MiNK Therapeutics

    Relapsed/Refractory Multiple Myeloma

    phase 1 small molecule completed

    1 trial

  8. agenT-797

    MiNK Therapeutics

    Respiratory Distress Syndrome, Adult

    phase 1 small molecule completed

    1 trial

  9. agenT-797

    MiNK Therapeutics

    Tumor, Solid

    phase 1 small molecule completed

    1 trial

  10. alisertib

    Takeda

    Acinar Cell Adenocarcinoma of the Pancreas

    phase 1 small molecule completed

    1 trial

  11. alisertib

    Takeda

    Advanced Malignancies

    phase 1 small molecule completed

    2 trials

  12. alpha receptor antagonist

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Prostatic Hypertrophy, Benign

    phase 1 small molecule active

    1 trial

  13. amifostine

    Ultragenyx UK Limited

    Fanconi's Anemia

    phase 1 small molecule active

    1 trial

  14. amilo-5MER

    Galmed Pharmaceuticals

    Inflammatory Disease

    phase 1 small molecule completed

    1 trial

  15. amoxicillin-clavulanic acid

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  16. an inactivated whole virion H5N1 vaccine, adjuvanted

    Sinovac Research and Development Co.,

    Influenza

    phase 1 mab completed

    1 trial

  17. anle138b (TEV-56286)

    Teva Pharma GmbH

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  18. anti CD19 CAR NK cells

    The First People's Hospital of Lianyungang

    Antisynthetase Syndrome

    phase 1 mab active

    1 trial

  19. anti-BCMA/CD70-CAR-T cells

    Chongqing Precision Biotech Co., Ltd

    CAR T Cell Therapy

    phase 1 mab active

    1 trial

  20. anti-CD123 CAR-T treatment

    Nanjing Legend Biotech Co.

    Acute Leukemia

    phase 1 small molecule terminated

    1 trial

  21. anti-CD19 CAR NK

    Chongqing Precision Biotech Co., Ltd

    NHL

    phase 1 mab active

    1 trial

  22. anti-CD19 CAR-T

    The First People's Hospital of Lianyungang

    B-cell Adult Acute Lymphoblastic Leukemia

    phase 1 mab active

    1 trial

  23. anti-CD19 allo-CAR-T cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Relapsed Adult ALL

    phase 1 mab active

    1 trial

  24. anti-CD19-CAR T-cells, or anti-CD30-CAR T-cells, or anti-CD20/CD30-CAR T-cells

    The First People's Hospital of Lianyungang

    Relapsed/refractory Lymphoma

    phase 1 mab active

    1 trial

  25. anti-CD19-CAR-T cells

    Chongqing Precision Biotech Co., Ltd

    Systemic Lupus Erythematosus

    phase 1 mab active

    1 trial

  26. anti-EGFR monoclonal antibody

    Dragonboat Biopharmaceutical Company Limited

    Healthy Volunteers

    phase 1 small molecule active

    1 trial

  27. anti-thymocyte globulin

    Ultragenyx UK Limited

    Multiple Sclerosis

    phase 1 small molecule completed

    1 trial

  28. anti-thymocyte globulin

    Ultragenyx UK Limited

    Systemic Lupus Erythematosus

    phase 1 small molecule active

    1 trial

  29. ateganosine

    MAIA Biotechnology

    Resectable Hepatocellular Carcinoma

    phase 1 small molecule active

    1 trial

  30. atorvastatin

    Hoffmann-La Roche

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  31. autologous ET1402L1-CART cells

    AEON Biopharma

    Hepatocellular Carcinoma

    phase 1 mab terminated

    1 trial

  32. autologous FL-33 CAR T therapy

    Universal Integrated

    Refractory/Relapsed Acute Myeloid Leukaemia

    phase 1 small molecule active

    1 trial

  33. autologous cell-based delivery

    Regeneron Ireland Designated Activity Company (DAC)

    Hypoplastic Left Heart Syndrome

    phase 1 mab completed

    1 trial

  34. autologous decidual-like NK cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Abortion, Habitual

    phase 1 mab active

    1 trial

  35. avoralstat

    Biocryst

    Diabetic Macular Edema (DME)

    phase 1 small molecule terminated

    1 trial

  36. balapiravir [RO4588161]

    Hoffmann-La Roche

    Dengue

    phase 1 small molecule completed

    1 trial

  37. bbT369

    Regeneron UK Limited

    Diffuse Large B Cell Lymphoma (DLBCL)

    phase 1 mab terminated

    1 trial

  38. belapectin

    GALECTIN THERAPEUTICS INC

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  39. bendamustine

    Teva Pharma GmbH

    Malignancy

    phase 1 small molecule completed

    1 trial

  40. blinatumomab and auto-HSCT "sandwich " strategy

    The First People's Hospital of Lianyungang

    B-cell Acute Lymphoblastic Leukemia

    phase 1 other active

    1 trial

  41. bronchial basal cells

    The First People's Hospital of Lianyungang

    Chronic Respiratory Disease

    phase 1 mab active

    1 trial

  42. brontictuzumab

    Mereo BioPharma Group plc

    Metastatic Colorectal Cancer

    phase 1 small molecule completed

    1 trial

  43. buprenorphine

    BRIGHT MINDS BIOSCIENCES INC.

    Neonatal Abstinence Syndrome

    phase 1 small molecule completed

    1 trial

  44. cNP8

    United Therapeutics Europe Ltd

    Burns

    phase 1 small molecule completed

    1 trial

  45. cannabis

    BRIGHT MINDS BIOSCIENCES INC.

    Behavioral Pharmacology of Cannabis

    phase 1 small molecule completed

    1 trial

  46. casdatifan

    Arcus Biosciences

    Clear Cell Renal Cell Carcinoma

    phase 1 small molecule active

    1 trial

  47. cefprozil

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  48. cemiplimab

    Regeneron UK Limited

    Relapsed/Refractory Aggressive B-Cell Lymphoma

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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