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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. hypo-fractionated SRS

    United Therapeutics Europe Ltd

    Metastatic Cancer

    phase 1 other completed

    1 trial

  2. iC9.GD2.CAR.IL-15 T Infusion

    United Therapeutics Europe Ltd

    Lung Cancer

    phase 1 mab active

    1 trial

  3. iC9.GD2.CAR.IL-15 T-cells

    United Therapeutics Europe Ltd

    Neuroblastoma

    phase 1 mab active

    1 trial

  4. iNexin™ (0.08% aCT1)

    United Therapeutics Europe Ltd

    Dry Eye Disease

    phase 1 small molecule completed

    1 trial

  5. iTBS to the left dlPFC

    BRIGHT MINDS BIOSCIENCES INC.

    Chronic Pain

    phase 1 other completed

    1 trial

  6. idronoxil

    KAZIA THERAPEUTICS LTD

    Unspecified Adult Solid Tumor, Protocol Specific

    phase 1 small molecule completed

    1 trial

  7. illuccix 68Ga-PSMA-11 Total Body PET-CT

    Telix Innovations

    Metastatic Castration-resistant Prostate Cancer

    phase 1 small molecule active

    1 trial

  8. iloperidone (oral tablet)

    Vanda Pharmaceuticals Netherlands B.V.

    Safety and Tolerability of Iloperidone

    phase 1 small molecule completed

    1 trial

  9. imatinib mesylate

    Children's Hospital of Fudan University

    Leukemia

    phase 1 small molecule completed

    1 trial

  10. immediate release guanfacine hydrochloride

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  11. indibulin

    Alaunos Therapeutics

    Solid Tumors

    phase 1 small molecule active

    2 trials

  12. indibulin

    Alaunos Therapeutics

    Advanced Cancer

    phase 1 small molecule completed

    1 trial

  13. interceptive orthodontic treatments

    NORTHWEST BIOTHERAPEUTICS INC

    Malocclusion

    phase 1 other active

    1 trial

  14. interleukin-4 PE38KDEL cytotoxin

    NEUROCRINE BIOSCIENCES INC

    Breast Cancer

    phase 1 mab completed

    1 trial

  15. intraconazole

    ENANTA PHARMACEUTICALS INC

    NASH - Nonalcoholic Steatohepatitis

    phase 1 small molecule completed

    1 trial

  16. iridoid enriched mixed fruit beverage

    International Peace Maternity and Child Health Hospital

    Oxidative Stress

    phase 1 other completed

    1 trial

  17. itraconazole

    Agios Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  18. ivosidenib (AG-120)

    Agios Netherlands B.V.

    Healthy

    phase 1 small molecule completed

    1 trial

  19. ketamine

    Summit Therapeutics

    Multiple Sclerosis

    phase 1 small molecule completed

    1 trial

  20. l-THP (l-tetrahydropalmatine)

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Use

    phase 1 small molecule completed

    1 trial

  21. laquinimod

    Teva Pharma GmbH

    Pharmacokinetics

    phase 1 small molecule completed

    1 trial

  22. limonene containing massage oil

    United Therapeutics Europe Ltd

    Breast Cancer

    phase 1 other completed

    1 trial

  23. linvoseltamab

    Regeneron UK Limited

    Food Allergy

    phase 1 small molecule active

    1 trial

  24. lipegfilgrastim

    Teva Pharma GmbH

    Pharmacokinetics

    phase 1 small molecule completed

    1 trial

  25. liposomal cytarabine

    Pacira Ireland Limited

    Brain and Central Nervous System Tumors

    phase 1 small molecule active

    1 trial

  26. locally manufactured adoptive cellular therapy (ACT) product

    Iovance Biotherapeutics B.V.

    Malignant Pleural Effusion

    phase 1 mab active

    1 trial

  27. lofexidine HCl

    BRIGHT MINDS BIOSCIENCES INC.

    Renally Impaired Subjects

    phase 1 small molecule completed

    1 trial

  28. lumacaftor 200 mg q12h + ivacaftor 250 mg q12h

    Vertex Pharmaceuticals (Australia) Pty.

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  29. lumbar puncture

    Takeda

    Crohn's Disease

    phase 1 small molecule completed

    1 trial

  30. mHealth application (custom)

    BRIGHT MINDS BIOSCIENCES INC.

    Cognitive Function Abnormal

    phase 1 other completed

    1 trial

  31. mPEG-r-crisantaspase

    Jazz Pharmaceuticals Ireland Limited

    Hematologic Malignancies

    phase 1 mab completed

    1 trial

  32. medroxyprogesterone acetate

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  33. mesenchymal stem cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Peripheral Vascular Disease

    phase 1 mab active

    1 trial

  34. metformin hydrochloride 500 mg tablet

    PMV Pharmaceuticals

    TP53 Y220C Mutation

    phase 1 small molecule active

    1 trial

  35. metyrapone & oxazepam

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Use Disorder

    phase 1 small molecule completed

    1 trial

  36. mifepristone + fluvastatin

    CORCEPT THERAPEUTICS INC

    Healthy Subjects

    phase 1 small molecule completed

    1 trial

  37. milatuzumab

    United Therapeutics Europe Ltd

    Lupus Erythematosus, Cutaneous

    phase 1 small molecule completed

    1 trial

  38. mipomersen

    IONIS PHARMACEUTICALS INC

    Healthy Volunteer

    phase 1 small molecule completed

    3 trials

  39. mipomersen sodium

    IONIS PHARMACEUTICALS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  40. mitoxantrone hydrochloride

    Karyopharm Therapeutics Inc

    Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities

    phase 1 small molecule completed

    1 trial

  41. mitragynine

    BRIGHT MINDS BIOSCIENCES INC.

    Safety and Tolerability in Healthy Subjects

    phase 1 small molecule active

    1 trial

  42. monoclonal antibody M-T412

    Ultragenyx UK Limited

    Multiple Sclerosis

    phase 1 small molecule completed

    1 trial

  43. namilumab (MT203)

    Takeda

    Rheumatoid Arthritis

    phase 1 small molecule completed

    1 trial

  44. narfurine hydrochloride orally disintegrating tablets

    The First People's Hospital of Lianyungang

    Improvement of Pruritus in Hemodialysis Patients

    phase 1 small molecule active

    1 trial

  45. neratinib

    PUMA BIOTECHNOLOGY, INC.

    Healthy

    phase 1 small molecule completed

    5 trials

  46. neratinib

    PUMA BIOTECHNOLOGY, INC.

    Tumors

    phase 1 small molecule completed

    1 trial

  47. nesvacumab (REGN910/ SAR307746)

    Regeneron UK Limited

    Solid Tumors

    phase 1 small molecule completed

    2 trials

  48. new formulations of 611

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Atopic Dermatitis

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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