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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 64 of 99

  1. OPB-51602

    Hospital Authority, Hong Kong

    Nasopharyngeal Carcinoma

    phase 1 small molecule terminated

    1 trial

  2. OPC-108459

    Otsuka Beijing Research Institute

    Atrial Fibrillation

    phase 1 small molecule completed

    1 trial

  3. OPC1

    Lineage Cell Therapeutics

    Spinal Cord Injury Cervical

    phase 1 mab active

    1 trial

  4. OPRX-106

    Protalix BioTherapeutics

    Human Volunteer

    phase 1 small molecule completed

    1 trial

  5. ORG-129

    Agomab Therapeutics NV

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  6. ORIC-101

    Topiloric/Uriadec

    Prostatic Neoplasms

    phase 1 small molecule terminated

    1 trial

  7. ORIC-101

    Topiloric/Uriadec

    Solid Tumor

    phase 1 small molecule terminated

    1 trial

  8. ORIC-101

    Topiloric/Uriadec

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  9. ORIC-114

    Topiloric/Uriadec

    Food Effect in Healthy Participants

    phase 1 small molecule completed

    1 trial

  10. ORIC-114 Dose 1 + amivantamab

    Topiloric/Uriadec

    Solid Tumors

    phase 1 small molecule active

    1 trial

  11. ORIC-533

    Topiloric/Uriadec

    Relapsed or Refractory Multiple Myeloma

    phase 1 small molecule completed

    1 trial

  12. ORIC-944

    Topiloric/Uriadec

    Metastatic Prostate Cancer

    phase 1 small molecule active

    1 trial

  13. ORKA-001

    Oruka Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  14. ORKA-002

    Oruka Therapeutics

    Healthy Volunteers

    phase 1 small molecule active

    1 trial

  15. OROS-MPH

    BRIGHT MINDS BIOSCIENCES INC.

    Methamphetamine Dependence

    phase 1 small molecule completed

    1 trial

  16. ORX142 Tablets

    Centessa Pharmaceuticals plc

    Excessive Daytime Sleepiness

    phase 1 small molecule active

    1 trial

  17. ORX489 Tablets

    Centessa Pharmaceuticals plc

    Healthy Adult Male and Female Volunteers

    phase 1 small molecule active

    1 trial

  18. Obatoclax mesylate (GX15-070MS)

    Teva Pharma GmbH

    Hematological Malignancies

    phase 1 small molecule completed

    1 trial

  19. Obecabtagene autoleucel (obe-cel)

    Autolus GmbH

    Progressive Multiple Sclerosis

    phase 1 mab active

    1 trial

  20. Obecabtagene autoleucel (obe-cel)

    Autolus GmbH

    Systemic Lupus Erythematosus

    phase 1 mab active

    1 trial

  21. Octreotide

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Enterocutaneous Fistulas

    phase 1 small molecule completed

    1 trial

  22. Odronextamab

    Regeneron UK Limited

    B-cell Non-Hodgkins Lymphoma (B-NHL)

    phase 1 small molecule active

    1 trial

  23. Odronextamab multiple dose levels

    Regeneron UK Limited

    Non-Hodgkin Lymphoma

    phase 1 small molecule completed

    1 trial

  24. Olanzapine

    CORCEPT THERAPEUTICS INC

    Antipsychotic-induced Weight Gain

    phase 1 small molecule completed

    1 trial

  25. Olanzapine Extended Release

    Teva Pharma GmbH

    Schizophrenia, Schizoaffective Disorder

    phase 1 small molecule completed

    1 trial

  26. Olaparib tablets, 150 mg

    Sandoz Pty Ltd

    Ovarian Cancer

    phase 1 small molecule completed

    1 trial

  27. Olaratumab

    Eli Lilly and Company

    Malignancy

    phase 1 mab completed

    1 trial

  28. Olezarsen

    IONIS PHARMACEUTICALS INC

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  29. Olfactory ensheathing cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Infarction, Middle Cerebral Artery

    phase 1 other active

    1 trial

  30. Olinciguat

    Cyclerion Therapeutics

    Healthy

    phase 1 small molecule completed

    1 trial

  31. Ologen Collagen Matrix

    AEON Biopharma

    Congenital Glaucoma

    phase 1 other active

    1 trial

  32. Olomorasib

    Eli Lilly and Company

    Healthy

    phase 1 small molecule completed

    1 trial

  33. Olutasidenib Investigational Agent Administration

    RIGEL PHARMACEUTICALS INC

    Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

  34. Olverembatinib, APG-2575, Dexamethasone

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Lymphoblastic Leukemia, Acute, Childhood

    phase 1 small molecule active

    1 trial

  35. Omacetaxine

    Teva Pharma GmbH

    Hematologic Tumors

    phase 1 small molecule completed

    1 trial

  36. Omega 3 fatty acid

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Male Infertility Due to Hypospermatogenesis

    phase 1 small molecule active

    1 trial

  37. Omega-3 fatty acids

    NORTHWEST BIOTHERAPEUTICS INC

    Metabolic Syndrome X

    phase 1 other active

    1 trial

  38. Omeprazole 40 MG

    LEXICON PHARMACEUTICALS, INC.

    Drug-drug Interaction

    phase 1 small molecule completed

    1 trial

  39. Omnitram

    BRIGHT MINDS BIOSCIENCES INC.

    Pain

    phase 1 small molecule completed

    1 trial

  40. Onartuzumab

    Hoffmann-La Roche

    Carcinoma, Hepatocellular

    phase 1 small molecule completed

    1 trial

  41. Oncolytic Virus SDJ001

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Malignant Tumor

    phase 1 small molecule active

    1 trial

  42. Ondansetron

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    2 trials

  43. Ondansetron

    HALOZYME THERAPEUTICS, INC.

    Healthy

    phase 1 small molecule completed

    1 trial

  44. Ondansetron (ODFS)

    Aquestive Therapeutics

    Healthy

    phase 1 small molecule completed

    1 trial

  45. Ondansetron 8 mg ODFS without water

    Aquestive Therapeutics

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  46. One dose of investigational vaccine

    Sinovac Research and Development Co.,

    Hepatitis B

    phase 1 mab completed

    1 trial

  47. Ontamalimab

    Takeda

    Steatohepatitis

    phase 1 small molecule terminated

    1 trial

  48. Open label, Phase I study to assess and compare the pharmacokinetic parameters after multiple oral administration of stiripentol 1000 mg in renal impaired patients and matching controls with normal renal function

    Biocodex

    Patients with renal impairement

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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