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Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

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  1. PDR001

    Novartis Pharmaceuticals

    Non-small Cell Lung Cancer

    phase 1 small molecule terminated

    1 trial

  2. PEG-IFN alfa-2a BA-free formulation (Test)

    Hoffmann-La Roche

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  3. PEGCETACOPLAN (APL-2)

    Apellis Europe B.V.

    Geographic Atrophy

    phase 1 small molecule completed

    1 trial

  4. PEGPH20

    HALOZYME THERAPEUTICS, INC.

    Solid Tumor

    phase 1 small molecule completed

    2 trials

  5. PEGPH20

    HALOZYME THERAPEUTICS, INC.

    NSCLC

    phase 1 small molecule completed

    1 trial

  6. PEGPH20

    HALOZYME THERAPEUTICS, INC.

    Cholangiocarcinoma Non-resectable

    phase 1 small molecule terminated

    1 trial

  7. PEGylated recombinant candida urate oxidase

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Gout

    phase 1 small molecule active

    1 trial

  8. PEGylated recombinant human hyaluronidase PH20

    HALOZYME THERAPEUTICS, INC.

    Non-small Cell Lung Cancer

    phase 1 small molecule terminated

    1 trial

  9. PEGylated recombinant human interferon alpha-2b injection

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Hepatitis B, Chronic

    phase 1 small molecule active

    1 trial

  10. PENNVAX-B

    INOVIO PHARMACEUTICALS, INC.

    HIV-1 Infection

    phase 1 mab completed

    1 trial

  11. PET study of changes in [11C]AZ14132516 uptake following administration of multiple AZD7798 doses to patients with Crohn’s disease.

    AstraZeneca AB

    Crohn's disease

    phase 1 other active

    1 trial

  12. PET-imaging of two Vartumabs (F8scFv and C9scFv) in patients with solid tumors – a Phase 0 basket trial

    Lacuna Pharma Pty Ltd

    Multiple solid tumors including: colorectal carcinoma (CRC), pancreatic carcinoma, oesophageal or gastric carcinoma, head and neck squamous cell carcinoma (HNSCC), chondrosarcoma or osteosarcoma, bladder carcinoma, lung carcinoma and glioblastoma.

    phase 1 other active

    1 trial

  13. PF-03715455

    Pfizer

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  14. PF-05190457

    Pfizer

    Diabetes Mellitus, Type 2

    phase 1 small molecule completed

    1 trial

  15. PF-05280602

    CATALYST PHARMACEUTICALS, INC.

    Hemophilia A

    phase 1 mab completed

    1 trial

  16. PF-07038124 or vehicle

    Pfizer

    Healthy

    phase 1 small molecule completed

    1 trial

  17. PF-07868489 Placebo, PF-07868489

    Pfizer Australia Pty Ltd

    Pulmonary Arterial Hypertension

    phase 1 small molecule active

    1 trial

  18. PF614

    Ensysce Biosciences

    Healthy

    phase 1 small molecule completed

    1 trial

  19. PF614

    Ensysce Biosciences

    Recreational Drug Use

    phase 1 small molecule completed

    2 trials

  20. PF614

    Ensysce Biosciences

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  21. PF614 capsule

    Ensysce Biosciences

    Pharmacokinetics

    phase 1 small molecule active

    1 trial

  22. PF614 solution

    BRIGHT MINDS BIOSCIENCES INC.

    Pharmacokinetics

    phase 1 small molecule completed

    1 trial

  23. PG-033

    Prime Medicine

    Lichen Simplex Chronicus

    phase 1 small molecule active

    1 trial

  24. PH-762

    Phio Pharmaceuticals

    Squamous Cell Carcinoma of the Skin

    phase 1 small molecule active

    1 trial

  25. PHARMACOKINETICS OF PETRELINTIDE FOLLOWING ADMINISTRATION TO PARTICIPANTS WITH IMPAIRED HEPATIC FUNCTION

    Zealand Pharma A/S

    Healthy / hepatic impaired volunteers only study to assess PK parameters

    phase 1 other active

    1 trial

  26. PHASE I STUDY TO DETERMINE THE MAXIMUM TOLERATED DOSE FOR TRICHOSTATIN A IN SUBJECTS WITH RELAPSED OR REFRACTORY HEMATOLOGIC MALIGNANCIES

    Lacuna Pharma Pty Ltd

    relapsed/refractory hematologic malignancies

    phase 1 other active

    1 trial

  27. PIC1 Injection

    Chongqing Precision Biotech Co., Ltd

    Non-Hodgkin Lymphoma

    phase 1 mab active

    1 trial

  28. PIPE-307

    Contineum Therapeutics

    Multiple Sclerosis

    phase 1 small molecule completed

    2 trials

  29. PIPE-791

    Contineum Therapeutics

    Idiopathic Pulmonary Fibrosis (IPF)

    phase 1 small molecule completed

    1 trial

  30. PIPE-791

    Contineum Therapeutics

    Multiple Sclerosis

    phase 1 small molecule completed

    1 trial

  31. PIPE-791

    Contineum Therapeutics

    Chronic Osteoarthritis Pain

    phase 1 small molecule completed

    1 trial

  32. PIVEKIMAB SUNIRINE

    AbbVie Deutschland GmbH & Co. KG

    Relapsed or Refractory Acute Myeloid Leukemia; Acute Myeloid Leukemia, Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

  33. PL2200 fasted

    Protalix BioTherapeutics

    Healthy

    phase 1 small molecule completed

    1 trial

  34. PLN-101095

    PLIANT THERAPEUTICS, INC.

    Advanced or Metastatic Solid Tumor

    phase 1 small molecule active

    1 trial

  35. PLX-PAD

    United Therapeutics Europe Ltd

    Pulmonary Arterial Hypertension

    phase 1 small molecule terminated

    1 trial

  36. PMV via Puffhaler® device

    Serum Life Science Europe GmbH

    Prophylaxis for the Measles Infection

    phase 1 mab completed

    1 trial

  37. PN-232

    Protagonist Therapeutics, Inc

    Healthy Subjects

    phase 1 small molecule completed

    1 trial

  38. PN-235

    Protagonist Therapeutics, Inc

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  39. PN-881 Oral Solution

    Protagonist Therapeutics, Inc

    Healthy Volunteer

    phase 1 small molecule active

    1 trial

  40. PNEUMOSTEM®

    Samsung Bioepis NL B.V.

    Pulmonary Arterial Hypertension (PAH)

    phase 1 mab active

    1 trial

  41. PNT001

    United Therapeutics Europe Ltd

    Traumatic Brain Injury

    phase 1 mab terminated

    1 trial

  42. PRA

    CNS Pharmaceuticals

    Pharmacokinetics

    phase 1 small molecule completed

    1 trial

  43. PRAX-628

    Chongqing Precision Biotech Co., Ltd

    Healthy

    phase 1 small molecule active

    1 trial

  44. PRG-1801

    Hospital Authority, Hong Kong

    Immune Thrombocytopenia

    phase 1 small molecule active

    1 trial

  45. PRG2302

    The First People's Hospital of Lianyungang

    Acute Lymphoblastic Leukemia

    phase 1 small molecule active

    1 trial

  46. PRO 2000/5 Gel (P)

    BRIGHT MINDS BIOSCIENCES INC.

    HIV Infections

    phase 1 small molecule completed

    1 trial

  47. PRO-040201

    Arbutus Biopharma Corp

    Hypercholesterolemia

    phase 1 small molecule terminated

    1 trial

  48. PROT-CL-NP101-015.01

    Teva Pharma GmbH

    Acute Migraine

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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