Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11696929

    Methods and systems for conserving highly expanded cells

    The Regents of the University of California · Granted Tue Jul 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11696903

    Compounds and methods for scavenging dicarbonyl electrophiles

    THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · Granted Tue Jul 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11696896

    Immunomodulatory nanoparticle treatment of brain injury

    Northwestern University · Granted Tue Jul 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11699503

    Methods of identifying and treating patient populations amenable to cancer immunotherapy

    The Regents of the University of California · Granted Tue Jul 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11701431

    Hydrogel prodrug for treatment

    Viking Scientific, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11702411

    Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors

    Revolution Medicines, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11702419

    Heterocyclic compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11702423

    BRM targeting compounds and associated methods of use

    Prelude Therapeutics, Incorporated · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11702415

    Crystalline hydrate of a JAK inhibitor compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11702701

    Means and methods for staging, typing and treating a cancerous disease

    Universität Regensburg · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11702473

    Site-specific antibody-drug conjugates

    ADC THERAPEUTICS SA · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11702477

    Bi-functional chimeric proteins and uses thereof

    Orionis Biosciences, Inc · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11701307

    Organic-inorganic composite particles, manufacturing method therefor, and cosmetic

    JGC Catalysts and Chemicals Ltd. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11701341

    Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease

    MEREO BIOPHARMA 1 LIMITED · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11701384

    Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments

    The Regents of the University of California · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11701420

    Parenteral norovirus vaccine formulations

    Takeda Vaccines, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11702400

    Salt types, crystal forms, and preparation methods for benzopyrazole compounds as RHO kinase inhibitors

    Medshine Discovery Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11702461

    T-cell modulatory multimeric polypeptides comprising reduced-affinity immunomodulatory polypeptides

    Cue Biopharma, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11702478

    Agonistic CD40 antibodies

    MAB Discovery GmbH · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11702657

    TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma

    The Regents of the University of California · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11702656

    Reprogramming of non-neuronal cells into neurons and methods and compositions to treat neurodegenerative diseases and disorders

    The Regents of the University of California · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11702630

    In vitro methods of differentiating stem cells into neurons and neurons generated using the same

    The Regents of the University of California · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11702453

    Materials and methods for inhibiting flavivirus infection

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11702448

    Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers

    RHYTHM PHARMACEUTICALS, INC. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11702442

    Cyclic dinucleotide compounds as sting agonists

    The Regents of the University of California · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11702417

    Compounds for improving mRNA splicing

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11701427

    Diels-alder conjugation methods

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11702389

    Piperidine derivatives as HDAC1/2 inhibitors

    Regenacy Pharmaceuticals, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11702646

    Methods for modulating RNA splicing

    PTC THERAPEUTICS, INC. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11702480

    Engineered antibodies and uses thereof

    The Regents of the University of California · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11701355

    Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF)

    TENAX THERAPEUTICS, INC. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11702427

    Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11701394

    Compositions and methods for treating cholestatic disease

    Seres Therapeutics, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11701331

    Toxic aldehyde related diseases and treatment

    Aldeyra Therapeutics, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11701338

    Use of gTso thal in manufacturing medicament for promotion of MS-275 to cross blood-brain barrier

    Northwest Institute of Plateau Biology, Chinese Academy of Sciences · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11701433

    Complexes for delivery of antigenic peptides

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11701354

    Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors

    Relay Therapeutics, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11701361

    p110-delta inhibitors treat and prevent autoimmunity while sparing the ability to mount an immune response to exogenous immunogens

    The Regents of the University of Colorado · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11701386

    Cell

    AUTOLUS LIMITED · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11701421

    Compositions and methods for stabilizing flaviviruses with improved formulations

    Takeda Vaccines, Inc. · Granted Tue Jul 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. EP 4210672

    HYALURONSÄURE ODER SALZ DAVON ZUR INHALATION ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN UND INHALATORVORRICHTUNG DAMIT

    ALFASIGMA SPA [IT] · Granted Wed Jul 19 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jul 14 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11708407

    Antigen binding molecule formats

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11707447

    C4-carbonothioate-substituted tryptamine derivatives and methods of using

    Enveric Biosciences Canada Inc. · Granted Tue Jul 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11707459

    Method for treating nervous system injuries using boldine and analogs thereof

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Jul 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11707550

    Polyphosphate-functionalized inorganic nanoparticles as hemostatic compositions and methods of use

    The Regents of the University of California · Granted Tue Jul 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11707457

    IRAK degraders and uses thereof

    Kymera Therapeutics, Inc. · Granted Tue Jul 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11707536

    Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11707510

    Nucleic acid-based botulinum neurotoxin for therapeutic use

    PRECLINICS DISCOVERY GMBH · Granted Tue Jul 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.