Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11273214

    Recombinant chimeric bovine/human parainfluenza virus 3 expressing RSV G and its use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11274123

    1,2,4-oxadiazole compounds as inhibitors of CD47 signalling

    Aurigene Discovery Technologies Limited · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11274077

    4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

    The United States of America Department of Health · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11274342

    Systems and methods for sequencing T cell receptors and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11274305

    Compositions and methods for in vivo excision of HIV-1 proviral DNA

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11273180

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11273131

    Pharmaceutical compositions with enhanced permeation

    Aquestive Therapeutics, Inc. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11273181

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11274163

    Ultra-stable protein ionic liquids

    United States of America as represented by the Secretary of the Air Force · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11274294

    TAL effector-mediated DNA modification

    Regents of the University of Minnesota · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11275080

    Methods for stratifying non-responders to therapies that block PD1/PDL1 axis

    The Regents of the University of California · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11274282

    Vesicular stomatitis vectors encoding Crimean-Congo hemorrhagic fever antigen

    The Board of Regents of the University of Texas System · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11273191

    Administering compositions for improved immune system functioning

    Script Essentials, LLC · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11274130

    HV1 modulators and uses

    The Regents of the University of California · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11274285

    Engineered meganucleases specific for recognition sequences in the Hepatitis B virus genome

    Precision BioSciences, Inc. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11274303

    Olmalinc as a diagnostic and therapeutic target for NAFLD, NASH, metabolic syndrome, and hepatic fibrosis

    The United States Government represented by the Department of Veterans Affairs · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11274149

    Anti-CD100 antibodies and methods for using the same

    VACCINEX, INC. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11273226

    Hydrogel prodrug for treatment

    Viking Scientific, Inc. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11273182

    Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in Crohn's disease

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11273150

    Compositions and methods for the treatment of presbyopia

    Lenz Therapeutics, Inc. · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11274318

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11273132

    Topical dapsone and dapsone/adapalene compositions and methods for use thereof

    ALMIRALL, LLC · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11273127

    Compositions, methods and uses for thermally stable multi-targeted antigens

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11273167

    Compositions and methods for modulating ABHD2 activity

    The Regents of the University of California · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11273431

    Biologically applicable water-soluble heterogeneous catalysts for para-hydrogen induced polarization

    The Regents of the University of California · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11274101

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. WO 2022053188

    NOUVELLES SÉQUENCES D'ADN ENCODANT DES ANTICORPS HUMAINS SCFV À ACTIVITÉ NEUTRALISANTE CONTRE LE SARS-CORONAVIRUS-2 ET LEURS UTILISATIONS

    ALFASIGMA SPA [IT] · Granted Thu Mar 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. WO 2022053708

    COMBINAISONS PHARMACEUTIQUES DESTINÉES À ÊTRE UTILISÉES POUR LE TRAITEMENT D'UN ADÉNOCARCINOME GASTRIQUE

    BASILEA PHARM INT AG [CH] · Granted Thu Mar 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11278529

    Methods for treating aggression associated with Alzheimer's disease

    OVID THERAPEUTICS INC. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11279701

    Immunomodulators and immunomodulator conjugates

    Regents of the University of Minnesota · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11278535

    Compounds and their methods of use

    PRAXIS PRECISION MEDICINES, INC. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11278592

    Methods and compositions for TUSC2 immunotherapy

    The Board of Regents of the University of Texas System · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11278521

    GAS5 binding compounds, formulations, and uses thereof

    THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSEL—PSG IV (024) · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11278573

    Methods and compositions to facilitate repair of avascular tissue

    Regenexx, LLC · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11278559

    Prodrug compounds and their uses

    Ligand Pharmaceuticals Incorporated · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11278626

    Compositions of polymeric nanowires and methods of making and using thereof

    The Regents of the University of California · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11278494

    Manufacturing of bupivacaine multivesicular liposomes

    Pacira Pharmaceuticals, Inc. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11279933

    Antisense oligonucleotides for the treatment of leber congenital amaurosis

    Stichting Radboud universitair medisch centrum · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11278554

    Compositions and methods for modification of biomolecules

    The Regents of the University of California · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11279686

    Nrf2 activating compounds and uses thereof

    Rigel Pharmaceuticals, Inc. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11278619

    DNA antibody constructs and method of using same

    Inovio Pharmaceuticals, Inc. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11278632

    Engineered nucleases useful for treatment of hemophilia A

    Precision BioSciences, Inc. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11279713

    Heterocyclic compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11279703

    Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof

    APTOSE BIOSCIENCES INC. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11278572

    Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11278493

    Ophthalmic formulations providing durable ocular lubrication

    ETERNATEAR, INC. · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11279922

    Delivery of therapeutic agents by a collagen binding protein

    Montefiore Medical Center · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11279763

    Integrin alpha 9 blockade suppresses lymphatic valve formation and promotes transplant survival

    The Regents of the University of California · Granted Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.