Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11534465

    Fecal matter for treatment of autoimmune diseases

    ACADEMISCH MEDISCH CENTRUM · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11534463

    Nucleic acids encoding kynurenine depleting enzymes

    The Board of Regents of the University of Texas System · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11534495

    Tissue factor-targeted antibody-drug conjugate

    SHANGHAI MIRACOGEN INC. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11535648

    Isolated darobactin A analog compounds and compositions thereof

    Northwestern University · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11535675

    Antigen-binding proteins that antagonize leptin receptor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11535677

    Chimeric antigen receptors targeting BCMA and methods of use thereof

    LEGEND BIOTECH USA INC. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11535684

    Chitosan derivatives and methods for preparing the same

    PRIMEX EHF · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11535773

    Coatings containing polymer modified enzyme for stable self-cleaning of organic stains

    Regents of the University of Minnesota · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11535663

    Methods for producing aflibercept in chemically defined media having reduced aflibercept variants

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11535851

    Reagents for treatment of hepatitis B virus (HBV) infection and use thereof

    Benitec IP Holdings Inc. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11535870

    Adeno-associated virus vectors encoding modified G6PC and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11536727

    Therapeutic antibodies against ROR-1 protein and methods for use of same

    The Regents of the University of California · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11533915

    Methods for making and using antimicrobial peptides

    Regents of the University of Minnesota · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11534429

    Small molecule inhibitors of bacterial efflux pumps and methods of using same

    The Regents of the University of Colorado · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11534430

    Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs

    Lutonix, Inc. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11534453

    RNAi therapy for hepatitis B virus infection

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11535658

    Activatable interleukin-2 polypeptides and methods of use thereof

    Werewolf Therapeutics, Inc. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11535650

    Modulation of complement activity

    RA PHARMACEUTICALS, INC. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11534493

    Pharmaceutical compositions of roflumilast in aqueous blends of water-miscible, pharmaceutically acceptable solvents

    ARCUTIS BIOTHERAPEUTICS, INC. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11535651

    Hepatitis B nanoparticle-based vaccine for influenza virus

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11535869

    CD8-specific antibody constructs and compositions thereof

    Sana Biotechnology, Inc. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11534488

    Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability

    VACCINEX, INC. · Granted Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11542320

    Nucleic acids encoding single domain antibodies to chikungunya virus

    The Government of the United States of America, as represented by the Secretary of the Navy · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11541077

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11541045

    Methods of treating cancer with farnesyltransferase inhibitors

    Kura Oncology, Inc. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11541070

    Administration of an anti-activin-A compound to a subject

    Atara Biotherapeutics, Inc. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11541075

    Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid

    ANIKA THERAPEUTICS, INC. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11541086

    Compositions and methods for treating Alzheimer's disease

    Northwestern University · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11542242

    Substituted piperazines as selective HDAC1,2 inhibitors

    Regenacy Pharmaceuticals, Inc. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11542302

    Modulators of melanocortin receptors for the treatment of depression and anxiety

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11542538

    Method for rapid in vitro synthesis of glycoproteins via recombinant production of n-glycosylated proteins in prokaryotic cell lysates

    Northwestern University · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11542275

    Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors

    Aurigene Discovery Technologies Limited · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11542312

    IL-2 superagonists in combination with anti-PD-1 antibodies

    Medicenna Therapeutics Inc. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11541032

    Composition containing sumo inhibitor and application

    CHINA PHARMACEUTICAL UNIVERSITY · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11542248

    Methods and compositions for inhibiting the interaction of menin with MLL proteins

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11542317

    Anti-VEGF protein compositions and methods for producing the same

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11541080

    Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them

    Finch Therapeutics Holdings LLC · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11542326

    Anti-IL-25 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11542504

    Compounds and methods for modulating ATXN1

    Ionis Pharmaceuticals, Inc. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11542410

    Coatings containing enzyme for stable self-cleaning of organic stains

    Regents of the University of Minnesota · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11541002

    Oral film compositions and dosage forms having precise active dissolution profiles

    Aquestive Therapeutics, Inc. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11542304

    Multimeric bicyclic peptide ligands

    BicycleTx Limited · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11542290

    Phenothiazine derivatives and uses thereof

    CAMP4 Therapeutics Corporation · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11542261

    Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors

    The United States of America as Represented by the Secretary, Dept. of Health and Human Services · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11542229

    Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

    The Board of Regents of the University of Texas System · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11542226

    Polyfunctional cannabinoids

    AXIM BIOTECHNOLOGIES. INC. · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11542238

    Pyrimidine cyclohexenyl glucocorticoid receptor modulators

    Corcept Therapeutics Incorporated · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11541177

    Injection spring for aged prefilled syringe and auto injector

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Jan 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.