Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11219631

    Foamable compositions, breakable foams and their uses

    Vyne Pharmaceuticals Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11220575

    Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method

    Nektar Therapeutics · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11219673

    Compositions and methods for delivery of biomacromolecule agents

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11220488

    Crystalline polymorph of Ponesimod

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11219695

    Methods and compositions for the treatment of Fabry disease

    Sangamo Therapeutics, Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11220479

    Glucosylceramide synthase inhibitors and therapeutic methods using the same

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11220524

    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)

    Prelude Therapeutics, Incorporated · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11219633

    Nucleobase analogue derivatives and their applications

    The Board of Regents of the University of Texas System · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11219621

    Methods for treating immunodeficiency disease

    X4 Pharmaceuticals, Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11219643

    Compositions for cellular restoration and methods of making and using same

    Advanced ReGen Medical Technologies, LLC · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11219697

    Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration

    The Regents of the University of California · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11219626

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11220535

    Anti-BCMA chimeric antigen receptors

    Cartesian Therapeutics, Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11220670

    Remnant tumor infiltrating lymphocytes and methods of preparing and using the same

    Iovance Biotherapeutics, Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11220486

    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11219604

    Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith

    Eupraxia Pharmaceuticals USA LLC · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11219636

    Compositions and methods for treating cancer

    The Medical Research, Infrastructure and Health Services Fund of the Tel-Aviv Medical Center · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11220509

    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors

    Mirati Therapeutics, Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11220501

    Solid forms of {6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl} methanol, a SHP2 inhibitor

    Revolution Medicines, Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11220496

    Compounds and method for treating autoimmune diseases

    Rigel Pharmaceuticals, Inc. · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11220477

    Modulators of the eIF2alpha pathway

    The Regents of the University of California · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11219614

    Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound

    Galera Labs, LLC · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11219552

    Intraocular filter device and methods of using same

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11219692

    Porphyrin modified telodendrimers

    The Regents of the University of California · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11219608

    Triple combination formulation for treatment of chronic pain

    Northwestern University · Granted Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11224584

    Sleep apnea treatment

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11224645

    Glycoconjugate vaccine for leishmaniasis

    The Board of Regents of the University of Texas System · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11224630

    Medicinal composition for protection of joints, method for producing the same and use thereof

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11224595

    Subcutaneous delivery of poly(oxazoline) polymer conjugates

    Serina Therapeutics, Inc. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11225483

    Substituted fused pyrrolo-diazepinones and uses thereof

    Northwestern University · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11224659

    Solid solution compositions and use in severe pain

    Infirst Healthcare Limited · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11224577

    Treating infection by a platelet-targeting microbe using nanoparticles

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11224626

    Methods of identifying bacteriophages that can infect and kill host-adapted infectious pathogenic bacteria

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11225650

    Methods of using FIX polypeptides

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11225469

    Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11225662

    Peptide oligonucleotide conjugates

    Sarepta Therapeutics, Inc. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11224655

    Targeting microbubbles

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11224656

    Scintillator nanocrystal-containing compositions and methods for their use

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11225506

    Cell penetrating peptides and methods of making and using thereof

    Entrada Therapeutics, Inc. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11225641

    Probiotic Bifidobacterium strain

    PrecisionBiotics Group Limited · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11224647

    Safe potent single platform vaccine against Tier 1 select agents and other pathogens

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11224624

    Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11225477

    Inhibitors of influenza virus replication, application methods and uses thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11225514

    Nanobodies against cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif)

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11224646

    Intranasal delivery of a cyclic-di-nucleotide adjuvanted vaccine for tuberculosis

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11225460

    Pyrrolidineamide derivatives and uses thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11225525

    Antibodies for botulinum neurotoxins

    The Regents of the University of California · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11225648

    Modified DNase and uses thereof

    Protalix Ltd. · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.