Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11241415

    N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the κ opioid receptor

    Nektar Therapeutics · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11241445

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Compass Therapeutics LLC · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11241380

    Porous photonic crystals for drug delivery to the eye

    The Regents of the University of California · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11241478

    Adenovirus-associated viral vectors for expressing variants of tetratricopeptide repeat (TPR)-containing Rab8b interacting (TRIP8b) protein in neurons and uses thereof for treating major depressive disorder (MDD)

    Northwestern University · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11242333

    Inhibitors of plasma kallikrein

    KalVista Pharmaceuticals Limited · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11241512

    Stabilized radio-labeled anti-CD45 immunoglobulin compositions

    Actinium Phamaceuticals, Inc. · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11242335

    Fluorine-substituted indazole compounds and uses thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11242510

    Mammalian cells devoid of lactate dehydrogenase activity

    The Regents of the University of California · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11242525

    CRISPR/CAS-related methods and compositions for treating sickle cell disease

    Editas Medicine, Inc. · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11241499

    Human serum albumin in formulations

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11242380

    Method to produce a highly concentrated immunoglobulin preparation for subcutaneous use

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11241483

    Methods of treating mild brain injury

    The Regents of the University of California · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11242533

    RNA-nanostructured double robots and methods of use thereof

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11241451

    Modulators of IRF4 expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11242543

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11241458

    Cell preparations for extemporaneous use, useful for healing and rejuvenation in vivo

    RegenLab USA LLC · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11241498

    Room temperature stable lyophilized protein

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. WO 2022029639

    FORMULATIONS PHARMACEUTIQUES AMÉLIORÉES COMPRENANT DES INHIBITEURS DE PI3K

    BERLIN CHEMIE AG [DE] · Granted Thu Feb 10 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 05 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11246871

    Targeting adenosine A2A receptors for the treatment of levodopa-induced dyskinesias

    Northwestern University · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11247985

    Phenyl indole allosteric inhibitors of P97 ATPase

    The Regents of the University of California · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11246875

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Compass Therapeutics LLC · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11246937

    One-step processing of hydrogels for mechanically robust and chemically desired features

    The Board of Regents of the University of Texas System · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11246930

    Reoviruses having modified sequences

    ONCOLYTICS BIOTECH INC. · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11248044

    Methods for altering body composition by administering a GDF8 inhibitor and an Activin A inhibitor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11247968

    Lipocationic dendrimers and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11246950

    Combination cancer immunotherapy with pentaaza macrocyclic ring complex

    Galera Labs, LLC · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11248056

    Muscle targeting complexes and uses thereof for treating dystrophinopathies

    Dyne Therapeutics, Inc. · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11248213

    Platform for generating safe cell therapeutics

    The Regents of the University of California · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11246947

    Recombinant AAV-crumbs homologue composition and methods for treating LCA-8 and progressive RP

    Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11248039

    Immunoglobulin single variable domain antibody against RSV prefusion F protein

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11248270

    Methods and kits to identify Klebsiella strains

    Arizona Board of Regents on Behalf of Northern Arizona University · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11246926

    Polynucleotides encoding anti-C1s antibodies

    Bioverativ USA Inc. · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11246940

    Peptides whose uptake in cells is controllable

    The Regents of the University of California · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11246881

    Nanoparticle to target cancer

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11247969

    Biphenyl compounds useful as muscarinic receptor antagonists

    Theravance Biopharma R&D IP, LLC · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11246859

    Methods and compositions for treating non-ERK MAPK pathway inhibitor-resistant cancers

    Biomed Valley Discoveries, Inc. · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11246858

    Immunoresponsive methods of treating tumors

    INSTITUT PASTEUR DE MONTEVIDEO · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11247971

    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11246933

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11247974

    Small molecules that enable cartilage rejuvenation

    The Regents of the University of California · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11246961

    Engineered scaffolds for vascularized tissue repair

    The Regents of the University of California · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11248022

    Glypican-3 peptide reagents and methods

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11254652

    Crystalline forms of N-(4-(4-(cyclopropymethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

    Agios Pharmaceuticals, Inc. · Granted Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11254752

    Methods for treating cancer with bispecific anti-CD3xMUC16 antibodies and anti-PD-1 antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11254731

    Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11253445

    Oxidative hair color remover in tablet or pellet form

    Bright International, LLC · Granted Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11253508

    PPARy agonist for treatment of progressive supranuclear palsy

    Coherus BioSciences, Inc. · Granted Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11253546

    Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20

    The Regents of the University of California · Granted Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 17 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.