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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12246011

    Radiation mitigator and method of use thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Mar 11 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12246014

    Azetidine derivatives

    Ligand UK Development Limited · Granted Tue Mar 11 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. WO 2025052303

    ARN CIRCULAIRE ET PROCÉDÉS DE PRÉPARATION ASSOCIÉS

    BEIGENE SWITZERLAND GMBH [CH] · Granted Thu Mar 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. WO 2025051711

    TRAITEMENT PAR PTH D'UNE MALADIE RÉNALE CHRONIQUE

    ASCENDIS PHARMA BONE DISEASES AS [DK] · Granted Thu Mar 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12251370

    Small molecule inhibitors of the BfrB:Bfd interaction

    The Board of Regents for Oklahoma State University · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12251379

    Methods of inhibiting formation of alpha synuclein aggregates

    The Regents of the University of California · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12252714

    Halogenation of complex organic compounds

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12252746

    Anti-CD46 antibodies and methods of use

    The Regents of the University of California · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12252522

    Myokines for treating cell proliferative and metabolic diseases and disorders

    Northwestern University · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12252520

    Myosin 15 promoters and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12252544

    Anti-CD63 antibodies, conjugates, and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12252492

    Substituted fused pyrrolo-diazepinones and uses thereof

    Northwestern University · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12252497

    Ras inhibitors

    Revolution Medicines, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12252488

    HPK1 antagonists and uses thereof

    Nimbus Saturn, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12251561

    Minimally invasive dermal electroporation device

    Inovio Pharmaceuticals, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12251472

    Manufacturing of bupivacaine multivesicular liposomes

    Pacira Pharmaceuticals, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12251395

    RNAS for complement inhibition

    Apellis Pharmaceuticals, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12251468

    Manufacturing of bupivacaine multivesicular liposomes

    Pacira Pharmaceuticals, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12251470

    Lipid nanoparticle formulations

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12251432

    Biomarkers and immunogenic compositions for filarial parasites

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12251440

    Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12252493

    Imidazo[1,2-c]pyrimidine derivatives as PRC2 inhibitors for treating cancer

    Mirati Therapeutics, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12251417

    Antimicrobial compounds from the genus Delftia

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12251397

    Cross-linked hyaluronic acids and combinations with PRP/BMC

    REGEN LAB SA · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12251387

    Substituted quinoxalines and benzo[c][1,2,5]oxadiazoles as DNA-PK inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12252550

    Antibodies that bind to C1S and uses thereof

    DIANTHUS THERAPEUTICS OPCO, INC. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12251378

    Long-acting local anesthetic formulation

    UNIVERSITY OF CONNECTICUT · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12251372

    Antileishmanial compounds, compositions and use thereof

    The Regents of the University of California · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12252511

    Process for the preparation of cyclic depsipeptides

    OnKure, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12252703

    Closed-ended linear duplex DNA for non-viral gene transfer

    VOYAGER THERAPEUTICS, INC. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12252481

    Anti-viral compounds

    Aligos Therapeutics, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12252515

    Compositions and methods for inhibiting Wnt signaling

    The Regents of the University of California · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12252530

    Human antibodies to Fel d1 and methods of use thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12252552

    Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use

    Sutro Biopharma, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12252480

    Salt forms and polymorphs of (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1H-1,2,3-triazole-4-carboxamide

    The Board of Regents of the University of Texas System · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12251478

    Bioactive polymeric dressing for accelerated wound closure

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12251428

    Hydrogel composition, hydrogel biomedical material, method for facilitating regeneration of bone and manufacturing method of hydrogel composition

    China Medical University · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12251403

    Genetically engineered hematopoietic stem cells and uses thereof

    Vor Biopharma Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12251445

    Gamma-hydroxybutyrate delivering compounds and processes for making and using them

    Zevra Therapeutics, Inc. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12252464

    Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

    The Board of Regents of the University of Texas System · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12250931

    Genetically modified mouse with a humanized PNPLA3 gene and methods of use

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12251458

    Anti-aging preparation for skin and application thereof

    SOUTH CHINA NORMAL UNIVERSITY · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12251449

    Synthetic multidomain peptide biomaterials that inhibit inducible nitric oxide synthase

    The Board of Regents of the University of Texas System · Granted Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. WO 2025058008

    CONJUGUÉ ANTICORPS-MÉDICAMENT CONTENANT UN COMPOSÉ HÉTÉROCYCLIQUE AYANT POUR ACTIVITÉ L'INDUCTION DE LA DÉCOMPOSITION DE LA PROTÉINE KRAS MUTANTE G12D

    ASTELLAS PHARMA INC [JP] · Granted Thu Mar 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12258627

    Kelch domain containing 7B (KLHDC7B) variants and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12258333

    N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12258412

    Nucleic acid molecules encoding bispecific anti-BCMA x anti-CD3 antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12258401

    Anti-CD47 combination therapy

    TEVA PHARMACEUTICALS AUSTRALIA PTY LTD · Granted Tue Mar 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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