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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12186367

    Isoform Nell-1 peptide

    The Regents of the University of California · Granted Tue Jan 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12186436

    Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jan 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12187746

    C26-linked rapamycin analogs as mTOR inhibitors

    Revolution Medicines, Inc. · Granted Tue Jan 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12187762

    Dithiolsaccharide mucolytic agents and uses thereof

    The Regents of the University of California · Granted Tue Jan 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12186314

    Compositions and methods for treatment, amelioration, and prevention of anesthesia-induced hypothermia

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jan 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. IT 202300014295

    COMPOSIZIONI ORODISPERSIBILI COMPRENDENTI BETAMETASONE FOSFATO

    ALFASIGMA SPA [IT] · Granted Sun Jan 12 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Sat Jan 07 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12194059

    Compositions comprising citrate and applications thereof

    The Board of Regents of the University of Texas System · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12195766

    Tumor-selective E1a and E1b mutants

    The Regents of the University of California · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12195454

    Compounds for imaging tau proteins that accumulate in the brain

    National Institutes for Quantum and Radiological Science and Technology · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12194065

    Methods and compositions to enhance metabolic detoxification systems

    Nature's Sunshine Products, Inc. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12194150

    Levodopa dosing regimen

    AMNEAL PHARMACEUTICALS LLC · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12194091

    Antibodies that bind human C6 and uses thereof

    REGENESANCE B.V. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12195535

    Antibodies binding to VISTA at acidic pH

    Five Prime Therapeutics, Inc. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12194078

    Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant

    Cartesian Therapeutics, Inc. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12194082

    Compositions and methods for treatment of homocystinuria

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12194049

    Composition for treating carbapenem antibiotic-resistant Acinetobacter baumannii infection

    GUANGZHOU CENTURY CLINICAL RESEARCH CO., LTD · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12194081

    ARGINASE1 polypeptides

    IO Biotech ApS · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12195439

    C1-substituted isopropylamine fused heterocyclic mescaline derivatives

    Enveric Biosciences Canada Inc. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12194090

    Tetanus vaccine platform for embedding COVID-19 vaccine

    Prime Bio, Inc. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12195804

    Treatment of squamous cell carcinoma

    The Board of Regents of the University of Texas System · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12194079

    Therapeutic regimen for the treatment of Fabry using stabilized alpha-galactosidase

    Protalix Ltd. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12194061

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12195773

    PH20 polypeptide variants, formulations and uses thereof

    HALOZYME, INC. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12195724

    Methods of producing T cell populations enriched for stable regulatory T-cells

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12194138

    Devices and methods for delivering therapeutics

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12195453

    Antiproliferation compounds and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12195768

    System and method for modulating stress granule assembly

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12194064

    Process of producing concentrated therapeutic phospholipid composition from krill extracts containing high level of free fatty acids

    Aker BioMarine Human Ingredients AS · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12195447

    Azolopyrimidine for the treatment of cancer-related disorders

    Arcus Biosciences, Inc. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12194016

    Methods of providing solriamfetol therapy to subjects with impaired renal function

    AXSOME MALTA LTD. · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12194084

    Multi-subunit vaccines to elicit both MHC- and CD1-restricted T cell responses

    Northwestern University · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12195558

    Targeted delivery system and methods of use therefor

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12195620

    Controlled entrapment and release of molecular cargo

    The Regents of the University of California · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12195540

    Antibodies that bind integrin αvβ8 and uses thereof

    The Regents of the University of California · Granted Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. CN 119325492

    Fluorescent probe targeting CA-IX

    BRACCO IMAGING SPA · Granted Fri Jan 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Thu Jan 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12201721

    Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12202798

    Antimicrobial compounds, compositions, and articles of manufacture for selectively inhibiting pathogenic microbes

    The Board of Regents of the University of Oklahoma · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12202797

    Method for producing pyrrole compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12201598

    Immunoregulatory microparticles for modulating inflammatory arthritides

    The Regents of the University of California · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12201604

    Treatment of circadian rhythm disorders

    VANDA PHARMACEUTICALS INC. · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12201685

    Methods of modulating immune responses with cationic lipid vaccine compositions

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12201655

    Antimicrobial therapy

    The Regents of the University of California · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12201593

    Oral pharmaceutical formulations of bitter compounds for asthma

    Aardvark Therapeutics, Inc. · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12201601

    Treatment for obesity

    AXSOME MALTA LTD. · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12201699

    Compositions and methods for promoting homology directed repair

    Editas Medicine, Inc. · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12201683

    Methods for preventing dengue and hepatitis a

    Takeda Vaccines, Inc. · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. CN 119343336

    1, 4-bis-(2-hydroxy-benzyl)-1, 4, 7-triazacyclononane derivatives and similar compounds as ligands in iron (iii) complexes for use as MRI contrast agents

    BRACCO IMAGING SPA · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12202880

    HLA engineering methods and compositions for treatment of autoimmunity

    The Regents of the University of Colorado · Granted Tue Jan 21 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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