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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12268777

    Compositions and methods for treating eosinophilic disorders

    The Regents of the University of California · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12268720

    Bacteriophage for treatment and prevention of E. coli and B. fragilis infections

    Armata Pharmaceuticals, Inc. · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12268737

    Stabilized influenza hemagglutinin stem region trimers and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12269805

    Inhibitors of platelet function and methods for use of the same

    The Regents of the University of California · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12269860

    Compositions and methods comprising engineered chimeric antigen receptor and modulator of CAR

    AUTOLUS LIMITED · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12269888

    Artificial cell death polypeptide for chimeric antigen receptor and uses thereof

    Century Therapeutics, Inc. · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12269897

    Anti-PCSK9 antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12268831

    Swallowable drug delivery device and methods of drug delivery

    Rani Therapeutics, LLC · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12268700

    3-o-sulfo-galactosylceramide analogs as activators of type II NKT cells and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12268673

    Anhydrous compositions of mTOR inhibitors and methods of use

    PALVELLA THERAPEUTICS, INC. · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12268678

    Formulations of hydroxypyridonate actinide/lanthanide decorporation agents

    The Regents of the University of California · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12268688

    Compositions and methods of use for modified release minoxidil

    Veradermics Incorporated · Granted Tue Apr 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12275964

    Variant type V CRISPR/Cas effector polypeptides and methods of use thereof

    The Regents of the University of California · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12275966

    Genetically engineered cells

    The Regents of the University of California · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12275937

    Stereospecific linkages in RNA editing oligonucleotides

    ProQR Therapeutics II B.V. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12275957

    Next generation designer liver organoids and their methods of preparation and use

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12275955

    Combining iPSC derived effector cell types for immunotherapy use

    Fate Therapeutics, Inc. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12275940

    Conjugated antisense compounds and their use

    Ionis Pharmaceuticals, Inc. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12275684

    Methods for making and using endoxifen

    ATOSSA THERAPEUTICS, INC. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12275781

    Monoclonal antibodies against MHC-bound human dickkopf-1 peptides and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12275769

    Activatable interleukin 12 polypeptides and methods of use thereof

    Werewolf Therapeutics, Inc. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12274735

    IL-4-fusion formulations for treatment of central nervous system (CNS) tumors

    Medicenna Therapeutics Inc. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12274710

    Compound for regulating body weight imbalance, composition thereof and application thereof

    GUANGZHOU CENTURY CLINICAL RESEARCH CO., LTD · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12274725

    Zika virus strains for treatment of glioma

    The Board of Regents of the University of Texas System · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12275758

    Prefusion RSV F proteins and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12274759

    Affibody proteins specific for B7-H3 (CD276)

    Regents of the University of Minnesota · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12275685

    Oligo-benzamide analogs and their use in cancer treatment

    The Board of Regents of the University of Texas System · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12274741

    Cattle fever tick-infestation vaccines and uses thereof

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12275792

    Antigen-binding proteins that activate the leptin receptor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12274684

    Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

    United Therapeutics Corporation · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12274747

    Compositions and methods for treating cytokine release syndrome

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12275786

    Anti-thyroglobulin t cell receptors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12274696

    Methods of administering nalbuphine

    Trevi Therapeutics, Inc. · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12274723

    Bacteriophage compositions and methods for treatment of bacterial infections

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12275788

    Single-domain antibodies against CD33 and constructs thereof

    Legend Biotech Ireland Limited · Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. TW 202515903

    Anti-PD-1-based treatment before and after surgery

    BEIGENE SWITZERLAND GMBH [CH] · Granted Wed Apr 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Apr 11 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. TW 202515875

    Solid forms comprising a B-RAF kinase dimer inhibitor, methods of preparation, and uses therefor

    BEIGENE SWITZERLAND GMBH [CH] · Granted Wed Apr 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Apr 11 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 2025120959

    NEW FORMULATIONS OF PITOLISANT AND METHODS OF USE

    BIOPROJET PHARMA [FR] · Granted Thu Apr 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. WO 2025078995

    COMPOSÉS DE 6-(PYRIMIDIN-4-YL)QUINOLÉINE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE KINASE DÉPENDANTE DE LA CYCLINE

    BEIGENE SWITZERLAND GMBH [CH] · Granted Thu Apr 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. WO 2025077836

    LIPIDES IONISABLES ET NANOPARTICULES LIPIDIQUES POUR ADMINISTRATION D'ARN

    BEIGENE SWITZERLAND GMBH [CH] · Granted Thu Apr 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12281327

    Lymphohematopoietic engineering using CAS9 base editors

    Regents of the University of Minnesota · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12281321

    Frataxin expression constructs having engineered promoters and methods of use thereof

    VOYAGER THERAPEUTICS, INC. · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12281310

    Use of trinucleotide repeat RNAs to treat cancer

    Northwestern University · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12281173

    Methods for treating patients with hyperlipidemia by administering a PCSK9 inhibitor in combination with an ANGPTL3 inhibitor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12281164

    Genetically engineered dual-targeting chimeric antigen receptor and use thereof

    WEST CHINA HOSPITAL, SICHUAN UNIVERSITY · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12281140

    Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof

    Enanta Pharmaceuticals, Inc. · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12281105

    Contraceptive compounds and methods

    Regents of the University of Minnesota · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12281122

    PI3K inhibitors

    Cogent Biosciences, Inc. · Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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