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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12234277

    Hydrophobic interaction chromatography for viral clearance

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12233081

    Hygromycin a compounds and methods of treating spirochete diseases

    Northwestern University · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12233092

    MSC-NTF specific exosomes and use thereof

    BRAINSTORM CELL THERAPEUTICS LTD. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12233124

    Recombinant metapneumovirus f proteins and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12234230

    Substituted benzyl-triazole compounds for Cbl-b inhibition, and further uses thereof

    NURIX THERAPEUTICS, INC. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12233105

    Methods for storing and warming purified corticotropin compositions

    ANI Pharmaceuticals, Inc. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12233106

    C-type natriuretic peptide variants to treat skeletal dysplasia in children

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12233150

    Oral care compositions comprising star-shaped polymers

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12234300

    Conjugated hepcidin mimetics

    Protagonist Therapeutics, Inc. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12234302

    Chitosan derivatives and methods for preparing the same

    PRIMEX EHF · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12234460

    Methods of treating decreased bone mineral density with cluster of differentiation 109 (CD109) inhibitors

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12233080

    Lipotechoic acid for immune modulation

    Northwestern University · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12233087

    Palladium hyaluronic acid particles and methods of managing cancer or angiogenic conditions

    The United States Government represented byt The United States Department of Veterans Affairs · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12232492

    Disinfection of bacteriophages products using supercritical carbon dioxide

    PRECISIONBIOTIX TECHNOLOGIES INC. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12233104

    Combination of an IL-2RBETA-selective agonist and a long-acting IL-15 agonist

    Nektar Therapeutics · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12233090

    Bispecific or-gate chimeric antigen receptor responsive to CD20 and CD19

    The Regents of the University of California · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12233145

    Ultra-violet absorbing compounds

    CIIMAR—CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12233042

    Treatment of cutaneous disorders

    Verrica Pharmaceuticals Inc. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12234461

    Targeted non-viral DNA insertions

    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12233073

    Skin care formulations and skin cancer treatment

    Regents of the University of Minnesota · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12233132

    Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same

    Serina Therapeutics, Inc. · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12234263

    Influenza vaccines

    The Regents of the University of California · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12234294

    Pharmaceutical composition of a humanized anti-CD40 antibody

    Kiniksa Pharmaceuticals, GmbH · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12234288

    Immunogenic arginase 2 polypeptides

    IO Biotech ApS · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12234516

    Biomarkers of response to HIF-2-alpha inhibition in cancer and methods for the use thereof

    The Board of Regents of the University of Texas System · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12234474

    Method to prevent the myelin abnormalites associated with arginase deficiency

    The Regents of the University of California · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12234260

    Virus-like nanoparticles for oral delivery

    The Regents of the University of California · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12233241

    Methods and systems to validate physiologic waveform reliability and uses thereof

    The Regents of the University of California · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12233166

    Extended release compositions comprising pyridostigmine

    Amneal Complex Products Research LLC · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12234480

    Therapeutic methods involving modulating inflammasome activation of myeloid-derived suppressor cells

    Regents of the University of Minnesota · Granted Tue Feb 25 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. WO 2025040080

    TRAITEMENT DU CANCER DE L'OESOPHAGE PAR ANTI-LAG3, ANTI-PD-1 ET CHIMIOTHÉRAPIE

    BEIGENE SWITZERLAND GMBH [CH] · Granted Thu Feb 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 2025064917

    HVT AIV VECTORS AND USES THEREOF

    BOEHRINGER INGELHEIM VETMEDICA GMBH [DE] · Granted Thu Feb 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 2025064788

    TREATMENT OF MIGRAINE

    ALLERGAN PHARMACEUTICALS INT LTD [IE] · Granted Thu Feb 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. WO 2025043148

    INHIBITEURS DE PROTÉINE DE LIAISON À L'ÉMOPAMIL ET LEURS UTILISATIONS

    BIOGEN MA INC [US] · Granted Thu Feb 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. WO 2025041076

    COMPOSÉS BICYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE CDK

    BEIGENE SWITZERLAND GMBH [CH] · Granted Thu Feb 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12239717

    Muscle targeting complexes and uses thereof for treating dystrophinopathies

    Dyne Therapeutics, Inc. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12240914

    Antibody against factor XIa in activated form of coagulant factor XI, preparation method therefor and use thereof

    MAB-LEGEND BIOTECH CO., LTD. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12241087

    Compositions and methods for differentiating stem cells into NK cells

    CRISPR THERAPEUTICS AG · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12240902

    Anti-TREM2 antibodies and methods of use thereof

    DENALI THERAPEUTICS INC. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12240846

    5- and 6-azaindole compounds for inhibition of Bcr-Abl tyrosine kinases

    Enliven Inc. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12240831

    Pyridazinone compounds and uses thereof

    EDGEWISE THERAPEUTICS, INC. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12239687

    Sustained release formulations using non-aqueous membrane emulsification

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12241067

    Compounds and methods for reducing LRRK2 expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12240907

    N-terminal scFv multispecific binding molecules

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12240816

    Deuterated compounds and uses thereof

    Aldeyra Therapeutics, Inc. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12239709

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12239694

    Methods and compositions for improved cognition

    The Regents of the University of California · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12239638

    Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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