Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12310944

    Selective butyrylcholinesterase inhibitor or pharmaceutically acceptable salt thereof, preparation method and use thereof

    CHINA PHARMACEUTICAL UNIVERSITY · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12310929

    Use of rasagiline for the treatment of restless legs syndrome

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12312589

    RNA-nanostructured double robots and methods of use thereof

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12312357

    PRMT5 inhibiting compounds and uses thereof

    ANTENGENE DISCOVERY LIMITED · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. WO 2025111409

    COMPOSÉS HÉTÉROCYCLIQUES DE FORMULE (I) DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE L'AMYOTROPHIE SPINALE PAR MODULATION DE L'ÉPISSAGE DE SMN2

    BIOGEN MA INC [US] · Granted Fri May 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Thu May 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. WO 2025111258

    COMPOSITIONS DE SÉROTYPE A DE NEUROTOXINE DE CLOSTRIDIUM BOTULINUM ET PROCÉDÉS DE FILTRATION AMÉLIORÉS

    ABBVIE INC [US] · Granted Fri May 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Thu May 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. WO 2025108443

    COMPOSÉS HÉTÉROCYCLIQUES ET COMPOSITIONS ASSOCIÉES, ET MÉTHODES DE TRAITEMENT CORRESPONDANTES

    BEIGENE SWITZERLAND GMBH [CH] · Granted Fri May 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Thu May 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. WO 2025111408

    COMPOSÉS POUR LE TRAITEMENT DE L'AMYOTROPHIE SPINALE ET DE LA MALADIE DE HUNTINGTON

    BIOGEN MA INC [US] · Granted Fri May 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Thu May 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12319740

    Methods for production of tissue resident memory-like T cells and use thereof

    The Board of Regents of the University of Texas System · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12319929

    Compositions and methods for the treatment of Parkinson's disease

    VOYAGER THERAPEUTICS, INC. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12318362

    Methods of providing solriamfetol therapy to subjects with impaired renal function

    AXSOME MALTA LTD. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12318375

    Method of treatment with tradipitant

    VANDA PHARMACEUTICALS INC. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12319724

    IL2 agonists and methods of use thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12318401

    Injectable shear-thinning hydrogel containing therapeutic agent for enhanced tumor therapy

    The Regents of the University of California · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12318457

    Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof

    GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12319703

    Macrocyclic fused pyrazoles as Mcl-1 inhibitors

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12319738

    Anti-FGFR2 antibodies in combination with chemotherapy agents in gastric cancer

    Five Prime Therapeutics, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12318356

    Use of cannabinoids in the treatment of epilepsy

    JAZZ PHARMACEUTICALS RESEARCH UK LIMITED · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12319916

    Modulation of gene transcription using antisense oligonucleotides targeting regulatory RNAs

    CAMP4 Therapeutics Corporation · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12318364

    Isoflavonoid compositions and methods for the treatment of cancer

    Aardvark Therapeutics, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12318376

    Compositions of a polyorthoester and an aprotic solvent

    Heron Therapeutics, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12318386

    Combination of XPO1 inhibitors and second agents for the treatment of prostate cancer

    Karyopharm Therapeutics Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12318397

    Methods and compositions for testosterone production

    Maximus Health, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12318418

    Modified adenoviruses

    University College Cardiff Consultants Limited · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12318426

    Compositions and methods for the treatment of metabolic and liver disorders

    Viking Therapeutics, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12318454

    Bicyclic peptide ligands specific for MT1-MMP

    BicycleRD Limited · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12318427

    Methods and compositions for modulation of tau proteins

    Sangamo Therapeutics, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12318483

    Manufacturing of bupivacaine multivesicular liposomes

    Pacira Pharmaceuticals, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12319651

    Crystalline forms and methods of producing crystalline forms of a compound

    Ligand Pharmaceuticals Incorporated · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12319657

    Solid state crystalline forms of a selective potassium channel modulator

    Xenon Pharmaceuticals Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12319693

    Crystalline forms of CFTR modulators

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12319940

    Methods for purification of arylsulfatase A

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12319708

    Agonists of peroxisome proliferator-activated receptor alpha (PPARα) and methods of use

    The Board of Regents of the University of Oklahoma · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12319684

    Agonists of the apelin receptor and methods of use thereof

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12318439

    Attenuating viral mutations in protein genes

    The Board of Regents of the University of Texas System · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12319752

    Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

    Northwestern University · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12319743

    Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject

    Dyne Therapeutics, Inc. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12319728

    Anti-VEGF protein compositions and methods for producing the same

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12319729

    Anti-Staphylococcus aureus specific antibody and nucleic acid encoding sequence thereof, and uses of the same

    China Medical University Hospital · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12319737

    NK engager molecules and methods of use thereof

    Regents of the University of Minnesota · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12317874

    Method of using a genetically modified mouse that expresses human albumin

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12318413

    Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome

    The Board of Regents of the University of Texas System · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12318487

    Solid tablet dosage form of ridinilazole

    SUMMIT (OXFORD) LIMITED · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12319711

    Spherical nucleic acids with tailored and active protein coronae

    Northwestern University · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12319744

    Treatment and prevention of hemophilic arthropathy with an antibody against endothelial cell protein C receptor (EPCR)

    The Board of Regents of the University of Texas System · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12319748

    Antibody binding to human HER2 and preparation method and use thereof

    SUNSHINE GUOJIAN PHARMACEUTICAL (SHANGHAI) CO., LTD. · Granted Tue Jun 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. EP 4563165

    PSMA-STEAP1-IMMUNGLOBULIN (DVD-IG)-MOLEKÜLE MIT ZWEIFACH VARIABLER DOMÄNE UND ARZNEIMITTELKONJUGATE

    ABBVIE INC [US] · Granted Wed Jun 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue May 30 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. WO 2025114430

    COMPOSITION À LIBÉRATION MODIFIÉE

    ABBOTT LABORATORIES GMBH [DE] · Granted Thu Jun 05 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 31 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.