Wednesday, July 8, 2026

Patent intelligence · US

US 12318386

Combination of XPO1 inhibitors and second agents for the treatment of prostate cancer

granted A61KA61K31/4166A61K31/433A61K31/506
Status granted
Linked drugs 4
Pipeline programs 6
Years to expiry 19
Applicant portfolio 38
Patent details — US 12318386
Jurisdiction
US
Status
granted
Grant date
Jun 3, 2025
Expiration
May 29, 2045
Claims
8
CPC classes
A61K, A61K31/4166, A61K31/433, A61K31/506
View on Google Patents ↗

Quick answer

US 12318386 (Combination of XPO1 inhibitors and second agents for the treatment of prostate cancer) is held by Karyopharm Therapeutics Inc.. Status: granted. Granted Jun 3, 2025. Expires May 29, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Key facts

Grant date
Expiration
Claims
8
CPC classes
A61K, A61K31/4166, A61K31/433, A61K31/506, A61K31/573, A61K31/58

More from Karyopharm Therapeutics Inc.

Related pharmaceutical patents in our USPTO index.

  1. US 12371420

    Polymorphs of Selinexor

    Karyopharm Therapeutics Inc. · Expires Jul 24, 2045

    granted
  2. US 12331040

    Substituted benzofuranyl and benzoxazolyl compounds and uses thereof

    Karyopharm Therapeutics Inc. · Expires Jun 12, 2045

    granted
  3. US 12291508

    Hydrazide containing nuclear transport modulators and uses thereof

    Karyopharm Therapeutics Inc. · Expires May 1, 2045

    granted
  4. US 11945794

    Nuclear transport modulators and uses thereof

    Karyopharm Therapeutics Inc. · Expires Mar 28, 2044

    granted
  5. US 11807629

    Polymorphs of Selinexor

    Karyopharm Therapeutics Inc. · Expires Nov 2, 2043

    granted
  6. US 11787771

    Hydrazide containing nuclear transport modulators and uses thereof

    Karyopharm Therapeutics Inc. · Expires Oct 12, 2043

    granted
  7. US 11753401

    Polymorphs of Selinexor

    Karyopharm Therapeutics Inc. · Expires Sep 7, 2043

    granted

Frequently asked questions

What is US patent 12318386?

US 12318386 (Combination of XPO1 inhibitors and second agents for the treatment of prostate cancer) is held by Karyopharm Therapeutics Inc.. Status: granted. Granted Jun 3, 2025. Expires May 29, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Who owns US 12318386?

Karyopharm Therapeutics Inc. is listed as the applicant in USPTO PatentsView records indexed by NovaPharmaNews. We track 38 pharmaceutical patents for this assignee.

When does US 12318386 expire?

Our index shows an expiration date of May 29, 2045 (19 years from today). Confirm material dates against USPTO, FDA Orange Book, or qualified counsel before contractual decisions.